National Cancer Institute - Cancer.gov

Alla Gustchina, Ph.D.

Alla Gustchina, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Staff Scientist
Center for Structural Biology

RESEARCH SUMMARY

My major research goal is to investigate structure-function relationship for a number of proteins, with particular emphasis on studies of aspartic proteases from mammals, parasites, and retroviruses. Other projects included studies of ATP-dependent protease Lon and serine-carboxyl proteases (sedolisins). I have been also involved in structural investigations of retroviral integrases.

Areas of Expertise

Aspartic Proteases

Publications

Selected Publications

Crystal structures of a plant trypsin inhibitor from Enterolobium contortisiliquum (EcTI) and of its complex with bovine trypsin

Zhou D, Lobo YA, Batista IF, Marques-Porto R, Gustchina A, Oliva ML, Wlodawer A.
PLoS ONE. 8: e62252, 2013. [ Journal Article ]

Structural studies of the interaction of Crataeva tapia bark protein with heparin and other glycosaminoglycans

Zhang F, Walcott B, Zhou D, Gustchina A, Lasanajak Y, Smith DF, Ferreira RS, Correia MT, Paiva PM, Bovin NV, Wlodawer A, Oliva ML, Linhardt RJ.
Biochemistry. 52: 2148-56, 2013. [ Journal Article ]

Structural studies of vacuolar plasmepsins

Bhaumik P, Gustchina A, Wlodawer A.
Biochim. Biophys. Acta. 1834: 207-223, 2012. [ Journal Article ]

Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41

Gustchina E, Li M, Ghirlando R, Schuck P, Louis JM, Pierson J, Rao P, Subramaniam S, Gustchina A, Clore GM, Wlodawer A.
PLoS ONE. 8: e78187, 2013. [ Journal Article ]

Crystal Structure of Crataeva tapia Bark Protein (CrataBL) and Its Effect in Human Prostate Cancer Cell Lines

Ferreira RD, Zhou D, Ferreira JG, Silva MC, Silva-Lucca RA, Mentele R, Paredes-Gamero EJ, Bertolin TC, Dos Santos Correia MT, Paiva PM, Gustchina A, Wlodawer A, Oliva ML.
PLoS ONE. 8: e64426, 2013. [ Journal Article ]