Tanja Grkovic, Ph.D.

Tanja Grkovic, Ph.D.
Staff Scientist
Natural Products Chemistry Section

Dr. Grkovic is a natural product chemist with an interest in understanding the structure and function of natural products in the early stages of drug discovery. She has extensive experience in the generation of natural product libraries for high-throughput screening and the isolation and structure elucidation of small molecules from marine, plant, and microbial biota.

Areas of Expertise

1) natural products, 2) prefractionated libraries, 3) NMR spectroscopy, 4) structure elucidation of small molecules, 5) high-throughput screening

Contact Info

Tanja Grkovic, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 562, Room 201
Frederick, MD 21702-1201
Ph: 301-846-5688
tanja.grkovic@nih.gov

Our work is focused on the isolation and identification of biologically active marine and plant-sourced natural products with emphasis on the development and applications of novel technologies. Our research efforts include the use of prefractionated libraries in new cell-based and cell-free molecularly targeted high-throughput screens, structure elucidation of complex natural products involving a range of spectroscopic and spectrometric methods, and development of metabolomic and bioinformatic tools for the dereplication of natural products in complex mixtures.

NIH Scientific Focus Areas:
Chemical Biology
View Dr. Grkovic's ORCID Bibliography

Selected Key Publications

  1. Grkovic T, Akee RK, Thornburg CC, Trinh SK, Britt JR, Harris MJ, Evans JR, Kang U, Ensel S, Henrich CJ, Gustafson KR, Schneider JP, O'Keefe BR.
    ACS Chem Biol. 15(4): 1104-1114, 2020. [ Journal Article ]
  2. Wilson BAP , Thornburg CC , Henrich CJ , Grkovic T , O'Keefe BR.
    Nat Prod Rep. 37(7): 893-918, 2020. [ Journal Article ]
  3. Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR.
    ACS Chem Biol. 13(9): 2484-2497, 2018. [ Journal Article ]
  4. Grkovic T, Pouwer RH, Vial ML, Gambini L, Noël A, Hooper JN, Wood SA, Mellick GD, Quinn RJ.
    Angew Chem Int Ed Engl. 53(24): 6070-4, 2014. [ Journal Article ]

Dr. Grkovic obtained her Ph.D. degree from the University of Auckland, New Zealand, followed by postdoctoral appointments at the Molecular Targets Laboratory, National Cancer Institute, and the Eskitis Institute for Drug Discovery in Brisbane, Australia. She spent six years as a Senior Scientist in the Natural Products Support Group at the Frederick National Laboratory for Cancer Research before joining the Molecular Targets Program in 2020 as a Visiting Staff Scientist in the Natural Products Chemistry Section.