Tanja Grkovic, Ph.D.
Dr. Grkovic is a natural product chemist with an interest in understanding the structure and function of natural products in the early stages of drug discovery. She has extensive experience in the generation of natural product libraries for high-throughput screening and the isolation and structure elucidation of small molecules from marine, plant, and microbial biota.
1) natural products, 2) prefractionated libraries, 3) NMR spectroscopy, 4) structure elucidation of small molecules, 5) high-throughput screening
Our work is focused on the isolation and identification of biologically active marine and plant-sourced natural products with emphasis on the development and applications of novel technologies. Our research efforts include the use of prefractionated libraries in new cell-based and cell-free molecularly targeted high-throughput screens, structure elucidation of complex natural products involving a range of spectroscopic and spectrometric methods, and development of metabolomic and bioinformatic tools for the dereplication of natural products in complex mixtures.
Selected Key Publications
National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library.ACS Chem Biol. 15(4): 1104-1114, 2020. [ Journal Article ]
- Nat Prod Rep. 37(7): 893-918, 2020. [ Journal Article ]
NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.ACS Chem Biol. 13(9): 2484-2497, 2018. [ Journal Article ]
NMR fingerprints of the drug-like natural-product space identify iotrochotazine A: a chemical probe to study Parkinson's disease.Angew Chem Int Ed Engl. 53(24): 6070-4, 2014. [ Journal Article ]
Dr. Grkovic obtained her Ph.D. degree from the University of Auckland, New Zealand, followed by postdoctoral appointments at the Molecular Targets Laboratory, National Cancer Institute, and the Eskitis Institute for Drug Discovery in Brisbane, Australia. She spent six years as a Senior Scientist in the Natural Products Support Group at the Frederick National Laboratory for Cancer Research before joining the Molecular Targets Program in 2020 as a Visiting Staff Scientist in the Natural Products Chemistry Section.