This is a LCP collection of available databases and tools to foster and advance liver cancer-related research.
Genomics Databases
Single Cell Atlas of Liver Cancer
scAtlasLC is a publicly available data portal of single-cell transcriptomic profiles of tumor cell communities in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. scAtlasLC can be used to evaluate gene expression in malignant cells and various non-malignant cells in liver cancer. It can be further used to determine gene expression in different subtypes of stromal cells and immune cells. The single-cell data used for scAtlasLC can be downloaded from Gene Expression Omnibus: GSE151530 LCP Contact: Xin Wei Wang
Cohorts and Case-Control Studies
Chile Biliary Longitudinal Study (Chile BiLS)
The Chile Biliary Longitudinal Study (Chile BiLS) is a cohort of women diagnosed with gallstones in an area of Chile with high risk for gallbladder cancer. The purpose of this study is to explore the etiology and natural history of gallbladder dysplasia and biliary cancer, identify potential non-invasive risk stratification methods, such as inflammatory markers, and develop strategies for prevention. LCP Contact: Jill Koshiol
Biliary Tract Cancer Pooling Project (BiTCaPP)
The Biliary Tract Cancer Pooling Project (BiTCaPP) is an international study involving 28 cohorts with over 4,500 biliary tract cancer cases from over 2.8 million participants. This resource allows for the prospective evaluation of risk factors. BiTCaPP is the first effort of its kind for the joint evaluation of cancers throughout the biliary tract and offers great promise for a more definitive understanding of the etiology of cancer across the entire biliary tract. LCP Contact: Jill Koshiol
Shanghai Biliary Tract Cancer Study
The Shanghai Biliary Tract Cancer Study is a case-control study conducted in China, including 627 BTC cases, 1,037 patients with biliary stones, and 959 population-based controls. This study allows cross-sectional evaluation of biologic markers and epidemiologic risk factors for gallbladder, extrahepatic bile duct, and ampulla of Vater cancer. LCP Contact: Jill Koshiol