Publications


Early Detection

A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma.
Liu J, Tang W, Budhu A, Forgues M, Hernandez MO, Candia J, Kim Y, Bowman ED, Ambs S, Zhao Y, Tran B, Wu X, Koh C, Surana P, Liang TJ, Guarnera M, Mann D, Rajaure M, Greten TF, Wang Z, Yu H, Wang XW
Cell.  182(2):317-328, 2020.


 


 

Diagnosis

Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis
Zhu K, Tang Y, Xu X, Dang H, Tang LY, Wang X, Wang XW, Zhang YE.
PLoS Biol. Dec 19;16(12): e3000091, 2018.

Mechanisms of hepatic stellate cell activation.
Tsuchida T, Friedman SL.  
Nat Rev Gastroenterol Hepatol. Jul;14(7):397-411, 2017.

Analysis of long noncoding RNA expression in hepatocellular carcinoma of different viral etiology.
Zhang Q, Matsuura K, Kleiner DE, Zamboni F, Alter HJ, Farci P.  
J Transl Med. Nov 28;14(1):328, 2016. 

Prognosis

Understanding the Cause and Consequence of Tumor Heterogeneity.
Khatib, S, Yotsawat, P, Hien, D, Wang XW
Trends in Cancer. Apr;6(4) 267-271, 2020.

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer
Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW.
Cancer Cell. Oct 14;36(4):418-430, 2019. 

Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma.
Zheng H, Pomyen Y, Hernandez MO, Li C, Livak F, Tang W, Dang H, Greten TF, Davis JL, Zhao Y, Mehta M, Levin Y, Shetty J, Tran B, Budhu A, Wang XW.  
Hepatology. Jul;68(1):127-140, 2018.

Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma
Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, Forgues M, Pomyen Y, Bhudhisawasdi V, Lertprasertsuke N, Chotirosniramit A, Pairojkul C, Auewarakul CU, Sricharunrat T, Phornphutkul K, Sangrajrang S, Cam M, He P, Hewitt SM, Ylaya K, Wu X, Andersen JB, Thorgeirsson SS, Waterfall JJ, Zhu YJ, Walling J, Stevenson HS, Edelman D, Meltzer PS, Loffredo CA, Hama N, Shibata T, Wiltrout RH, Harris CC, Mahidol C, Ruchirawat M, Wang XW. TIGER-LC Consortium.
Cancer Cell. Jul 0;32(1):57-70.e3, 2017.

Transcriptional Induction of Periostin by a Sulfatase 2-TGFβ1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma.
Chen G, Nakamura I, Dhanasekaran R, Iguchi E, Tolosa EJ, Romecin PA, Vera RE, Almada LL, Miamen AG, Chaiteerakij R, Zhou M, Asiedu MK, Moser CD, Han S, Hu C, Banini BA, Oseini AM, Chen Y, Fang Y, Yang D, Shaleh HM, Wang S, Wu D, Song T, Lee JS, Thorgeirsson SS, Chevet E, Shah VH, Fernandez-Zapico ME, Roberts LR.  
Cancer Res. Feb 1;77(3):632-645, 2017.

DNAJB1-PRKACA fusion kinase interacts with b-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma.
Kastenhuber ER, Lalazar G, Houlihan SL, Tschaharganeh DF, Baslan T, Chen CC, Requena D, Tian S, Bosbach B, Wilkinson JE, Simon SM, Lowe SW.  
Proc. Natl. Acad. Sci. U.S.A. 114: 13076-13084, 2017. 

Telomere Length and Survival of Patients with Hepatocellular Carcinoma in the United States.
Yang B, Shebl FM, Sternberg LR, Warner AC, Kleiner DE, Edelman DC, Gomez A, Dagnall CL, Hicks BD, Altekruse SF, Hernandez BY, Lynch CF, Meltzer PS, McGlynn KA.  
PLoS One. Nov 23;11(11):e0166828, 2016.

A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection.
Zhang DY, Goossens N, Guo J, Tsai MC, Chou HI, Altunkaynak C, Sangiovanni A, Iavarone M, Colombo M, Kobayashi M, Kumada H, Villanueva A, Llovet JM, Hoshida Y, Friedman SL.
Gut. Oct;65(10):1754-64, 2016. 

Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo.
Porat-Shliom N, Tietgens AJ, Van Itallie CM, Vitale-Cross L, Jarnik M, Harding OJ, Anderson JM, Gutkind JS, Weigert R, Arias IM.
Hepatology. Oct;64(4):1317-29, 2016.

p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer
Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW.
Cell. Jul 31;158(3):579-92, 2014. Erratum in: Cell. Jun 2;165(6):1546-154, 2016.

The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.
Chung JY, Hong SM, Choi BY, Cho H, Yu E, Hewitt SM.
Clin Cancer Res. Jan 15;15(2):660-7, 2009.

Treatment

Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice
Li D, Li N, Zhang Y-F, Fu H, Feng M, Schneider D, Su L, Wu X, Zhou J, Mackay S, Kramer J, Duan Z, Yang H, Kolluri A, Hummer AM, Torres MB, Zhu H, Hall MD, Luo X, Chen J, Wang Q, Abate-Daga D, Dropublic B, Hewitt SM, Orentas RJ, Greten TF, Ho M
Gastroenterology. Jun;158(8):2250-2265, 2020.

Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells
Ma C, Han M, Heinrich B, Fu Q, Zhang Q, Sandhu M, Agdashian D, Terabe M, Berzofsky JA, Fako V, Ritz T, Longerich T, Theriot CM, McCulloch JA, Roy S, Yuan W, Thovarai V, Sen SK, Ruchirawat M, Korangy F, Wang XW, Trinchieri G, Greten TF.  
Science. May 25;360(6391), 2018.

ONC201 kills breast cancer cells in vitro by targeting mitochondria.
Greer YE, Porat-Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde VN, Gilbert SF, Islam C, Ubaldini A, Ji Y, Gattinoni L, Soheilian F, Wang X, Hafner M, Shetty J, Tran B, Jailwala P, Cam M, Lang M, Voeller D, Reinhold WC, Rajapakse V, Pommier Y, Weigert R, Linehan WM, Lipkowitz S. 
Oncotarget. Apr 6;9(26):18454-18479, 2018. 

Tumor-Specific Zr-89 Immuno-PET Imaging in a Human Bladder Cancer Model
Escorcia FE, Steckler JM, Abdel-Atti D, Price EW, Carlin SD, Scholz WW, Lewis JS, Houghton JL.
Mol Imaging Biol. Mar 5; [Epub ahead of print], 2018. 

An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection
Shuptrine CW, Ajina R, Fertig EJ, Jablonski SA, Kim Lyerly H, Hartman ZC, Weiner LM.  
Cancer Immunol Immunother. Dec;66(12):1529-1544, 2017. 

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
Eggert T, Wolter K, Ji J, Ma C, Yevsa T, Klotz S, Medina-Echeverz J, Longerich T, Forgues M, Reisinger F, Heikenwalder M, Wang XW, Zender L, Greten TF.
Cancer Cell. Oct 10;30(4):533-547, 2016. 

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer. 
Dauch D, Rudalska R, Cossa G, Nault JC, Kang TW, Wuestefeld T, Hohmeyer A, Imbeaud S, Yevsa T, Hoenicke L, Pantsar T, Bozko P, Malek NP, Longerich T, Laufer S, Poso A, Zucman-Rossi J, Eilers M, Zender L.
Nat Med. Jul;22(7):744-53, 2016. 

Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signaling and protein synthesis.
Gao W, Tang Z, Zhang YF, Feng M, Qian M, Dimitrov DS, Ho M.  
Nat Commun. Mar 11; 6:6536, 2015. 

c-Abl modulates tumor cell sensitivity to antibody-dependent cellular cytotoxicity.
Murray JC, Aldeghaither D, Wang S, Nasto RE, Jablonski SA, Tang Y, Weiner LM.
Cancer Immunol Res. Dec;2(12):1186-98, 2014. 

Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma.
Feng M, Gao W, Wang R, Chen W, Man YG, Figg WD, Wang XW, Dimitrov DS, Ho M.
Proc Natl Acad Sci U S A. Mar 19;110(12):E1083-91, 2013. 

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L.  
Nature. Nov 9;479(7374):547-51, 2011.

Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors.
Escorcia FE, Henke E, McDevitt MR, Villa CH, Smith-Jones P, Blasberg RG, Benezra R, Scheinberg DA.
Cancer Res. Nov 15;70(22):9277-86, 2010. 

Population Studies

A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma.
Liu J, Tang W, Budhu A, Forgues M, Hernandez MO, Candia J, Kim Y, Bowman ED, Ambs S, Zhao Y, Tran B, Wu X, Koh C, Surana P, Liang TJ, Guarnera M, Mann D, Rajaure M, Greten TF, Wang Z, Yu H, Wang XW
Cell.  182(2):317-328, 2020.

Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma
Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, Forgues M, Pomyen Y, Bhudhisawasdi V, Lertprasertsuke N, Chotirosniramit A, Pairojkul C, Auewarakul CU, Sricharunrat T, Phornphutkul K, Sangrajrang S, Cam M, He P, Hewitt SM, Ylaya K, Wu X, Andersen JB, Thorgeirsson SS, Waterfall JJ, Zhu YJ, Walling J, Stevenson HS, Edelman D, Meltzer PS, Loffredo CA, Hama N, Shibata T, Wiltrout RH, Harris CC, Mahidol C, Ruchirawat M, Wang XW. TIGER-LC Consortium.
Cancer Cell. Jul 0;32(1):57-70.e3, 2017.

Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma.
Cancer Genome Atlas Research Network.  
Cell. Jun 15;169(7):1327-1341.e23, 2017.