The Center for Immuno-Oncology Translational Research area develops novel immunotherapeutics that are translated from hypothesis-driven preclinical studies to clinical trials. The Cellular Immunology Group is working to characterize the immune response of patients enrolled in our clinical trials to identify patients, prior to or early following therapy, who go on to respond well to various cancer immunotherapies. Our research program develops innovative methods to assess the immune response of cancer patients treated with combination immunotherapies as well as so-called “non-immune”‒based therapies. We investigate soluble analytes and specific immune cell subsets in the peripheral blood of patients to identify potential correlations with clinical responses. We also conduct preclinical and translational research in the areas of tumor immunology and immunotherapy, concentrating on mechanisms of tumor cell‒immune cell interactions and immune cell function, with a focus on combining cancer immunotherapies with novel targeted agents. These studies provide critical information toward the development of more effective immunotherapeutic approaches to cancer.