Duane H. Hamilton, Ph.D.

Duane H. Hamilton, Ph.D.
Staff Scientist
Head, Immunotherapeutics Group

Team Member of:

Dr. Hamilton is a Staff Scientist and Head of the Immunotherapeutics Group in the Laboratory of Tumor Immunology and Biology, NCI. He received his Ph.D. in Immunology from the University of Saskatchewan, Canada. Dr. Hamilton's research interests include cellular immunotherapy; tumor immunology; cancer vaccines. The Immunotherapeutics Group is working to identify and characterize tumor-specific neoepitopes and their use in combination therapies. We are also involved in the genetic modification to tumor cells to identify mechanisms of action of specific immunotherapeutic agents. This group evaluates techniques to identify tumor antigens unique to a patient’s own tumor. It is this group's belief that vaccinating patients with neoepitopes uniquely expressed by their tumor will improve the breadth of anti-tumor immunity generated by the lab's vaccine platforms, and result in greater immunological control of tumor growth.

Areas of Expertise

1) cancer immunotherapy, 2) CTL epitopes

Contact Info

Duane H. Hamilton, Ph.D.
Center for Cancer Research
National Cancer Institute
Bulding 10, Room 8B08
Bethesda, MD 20892
Ph: 240-858-3453
Duane.Hamilton@nih.gov

The main goal of our research program is to identify and characterize tumor-specific antigens and neoepitopes. We are evaluating techniques to identify tumor antigens unique to a patient’s own tumor. It is our belief that vaccinating patients with neoepitopes uniquely expressed by their tumor will improve the breadth of anti-tumor immunity generated by our vaccine platforms, and result in greater immunological control of tumor growth.

 

NIH Scientific Focus Areas:
Cancer Biology, Immunology
View Dr. Hamilton's PubMed Summary

Selected Key Publications

  1. Lee KL, Benz SC, Hicks KC, Nguyen A, Gameiro SR, Palena C, Sanborn JZ, Su Z, Ordentlich P, Rohlin L, Lee JH, Rabizadeh S, Soon-Shiong P, Niazi K, Schlom J, Hamilton DH
    Cancer Immunol Res. 7(8): 1359-1370, 2019. [ Journal Article ]
  2. Hamilton DH, Griner LM, Keller JM, Hu X, Southall N, Marugan J, David JM, Ferrer M, Palena C.
    Clin Cancer Res. 22: 6204-16, 2016. [ Journal Article ]
  3. Hamilton DH, Huang B, Fernando RI, Tsang KY, Palena C.
    Cancer Res. 74: 2510-2519, 2014. [ Journal Article ]
  4. Palena C, Hamilton DH.
    Adv Cancer Res. 128: 69-93, 2015. [ Journal Article ]
  5. Palena C, Fernando RI, Hamilton DH.
    OncoImmunol. 3: e27220, 2014. [ Journal Article ]

Dr. Duane Hamilton received his Ph.D. degree in Immunology from the University of Saskatchewan, Canada, in 2007. He subsequently joined the NIH as a Postdoctoral Fellow in the Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, and was appointed as a Staff Scientist in 2015. Dr. Hamilton’s current research focuses on the identification and characterization of novel tumor-specific antigens and neoepitopes that can help the immune system to target and eliminate cancer cells.

Name Position
Maria Del Mar Maldonado Montalban Ph.D. Postdoctoral Fellow (CRTA)
Laura Minang Biologist (Contr.)
Jenny Wu Postbaccalaureate Fellow (CRTA)