Caroline Jochems Frohlich, M.D., Ph.D.
Dr. Jochems Frohlich focuses on translational research investigating combinations of novel immunotherapeutic approaches to target various human cancers. Her group uses a combination of in vitro and in vivo studies in syngeneic and humanized mouse models to evaluate new immunotherapeutics, as well as combinations of immunotherapeutics with non-immune-based therapies
1) cancer immunotherapy, 2) clinical trials, 3) tumor immunology, 4) cellular immunology, 5) immune biomarkers
The Laboratory of Tumor Immunology and Biology develops novel immunotherapeutics that are translated from hypothesis-driven preclinical studies to clinical trials. The Cellular Immunology Group conducts translational research investigating combinations of new immunotherapeutic approaches to target various human cancers. We conduct both in vitro and in vivo studies in syngeneic and humanized mouse models to evaluate novel immunotherapeutics, as well as combinations of immunotherapeutics with non-immune-based therapies. Our group also studies patients' immune responses to provide critical information toward the development of more effective immunotherapeutic approaches to cancer.
Selected Key Publications
A combination trial of vaccine plus ipilimumab in metastatic castration-resistant prostate cancer patients: immune correlates..Cancer Immunol Immunother. 63(4): 407-18, 2014. [ Journal Article ]
Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells..Cancer Immunol Res. 3(10): 1148-1157, 2015. [ Journal Article ]
ADCC employing an NK cell line (haNK) expressing the high affinity CD16 allele with avelumab, an anti-PD-L1 antibody.Int J Cancer. 141(3): 583-593, 2017. [ Journal Article ]
- Oncotarget. 8(43): 75217-75231, 2017. [ Journal Article ]
The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex.Oncoimmunology. 8(2): e1532764, 2018. [ Journal Article ]
Caroline Jochems Frohlich received her M.D. from Gothenburg University, Sweden, and her Ph.D. in Immunology from the Institute of Medicine at the Sahlgrenska University Hospital, Gothenburg, Sweden in 2008. She subsequently joined the NIH as a Postdoctoral Fellow in the Laboratory of Tumor Immunology and Biology and was appointed as a Staff Scientist in 2019. Dr. Jochems Frohlich has authored approximately 50 scientific publications.
|Samuel Troy Pellom, Jr. Ph.D.||Postdoctoral Fellow (CRTA)|
|Nicholas Roller M.S.||Biologist (Contr.)|
|Claire Smalley Rumfield Ph.D.||Postdoctoral Fellow (Contr.)|