Ivy Yin, Ph.D.
Dr. Ivy Yin is interested in the cellular and molecular mechanisms of prostate cancer-related bone metastasis. Her current work focuses on the role of the TWEAK/Fn14 pathway, the TGF-β pathway and the Ras signaling pathway in the development and progression of prostate cancer metastasis to bone and brain.
1) mouse metastasis model, 2) mouse preclinical trial for anti-metastasis therapies, 3) live animal imaging, 4) metastatic bone disease
Selected Recent Publications
- Oncogene. 38(35): 6241-6255, 2019. [ Journal Article ]
High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer.Sci Rep. 8(1): 17239, 2018. [ Journal Article ]
A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening.Clin Cancer Res. 24(17): 4332-4345, 2018. [ Journal Article ]
Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer.Oncotarget. 8(44): 77181-77194, 2017. [ Journal Article ]
- Mol Cell Biol. 35(11): 1940-51, 2015. [ Journal Article ]