John A. Beutler, Ph.D.
John A. Beutler, Ph.D.
Associate Scientist
Head, Chemical Diversity Development Section

Center for Cancer Research
National Cancer Institute

Building 560-1, Room 11-86
Frederick, MD 21702-1201
301-846-1942

Dr. Beutler has identified several natural products which have potential for development as cancer drugs, among them, englerins, which are in preclinical development for kidney cancer and Ewing’s sarcoma, schweinfurthins, which are preclinical candidates in glioblastoma and malignant peripheral nerve sheath tumors, and salicylihalamides, of interest in sarcomas. As a staff scientist, Dr. Beutler oversees the Lab’s high-throughput screening libraries, information technology, and drug development efforts.

Areas of Expertise
natural products chemistry, high-throughput screening, molecular pharmacology

We are advancing two natural product projects towards the clinic: englerins for kidney cancer and Ewings sarcoma, and schweinfurthins for CNS tumors and other NF1-dependent conditions. These natural products both have unique mechanisms of action. In addition, our group builds and maintains the library of chemical diversity with which the MTL conducts high throughput screening campaigns based on CCR-identified molecular targets.

Selected Publications
  1. Turbyville TJ, Gürsel DB, Tuskan RG, Walrath JC, Lipschultz CA, Lockett SJ, Wiemer DF, Beutler JA, Reilly KM.
    Mol. Cancer Ther.. 9: 1234-43, 2010. [ Journal Article ]
  2. Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.
    Org. Lett.. 11: 57-60, 2009. [ Journal Article ]
  3. Boyd MR, Farina C, Belfiore P, Gagliardi S, Kim JW, Hayakawa Y, Beutler JA, McKee TC, Bowman BJ, Bowman EJ.
    J Pharmacol Exp Ther. 297: 114-20, 2001. [ Journal Article ]
  4. Beutler JA, Shoemaker RH, Johnson T, Boyd MR.
    J. Nat. Prod.. 61: 1509-12, 1998. [ Journal Article ]
  5. Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee M, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L.
    Cancer Cell. 23: 228-37, 2013. [ Journal Article ]

BA Chemistry, Vassar College 1972 MSc Phila College of Pharmacy & Science 1978 PhD Phila College of Pharmacy & Science 1980 Postdoctoral Fellowships Northeastern University 1980-1 Assistant Professor, Auburn University School of Pharmacy 1981-1983 University of Texas Medical School at Houston 1983-4

Name Position
Jason R. Evans Programmer / Analyst (Contr)
Ekaterina I. Goncharova Ph.D. Programmer / Analyst (Contr)
Cheryl Thomas B.S. Research Chemist

Summary

Dr. Beutler has identified several natural products which have potential for development as cancer drugs, among them, englerins, which are in preclinical development for kidney cancer and Ewing’s sarcoma, schweinfurthins, which are preclinical candidates in glioblastoma and malignant peripheral nerve sheath tumors, and salicylihalamides, of interest in sarcomas. As a staff scientist, Dr. Beutler oversees the Lab’s high-throughput screening libraries, information technology, and drug development efforts.

Areas of Expertise
natural products chemistry, high-throughput screening, molecular pharmacology

Research

We are advancing two natural product projects towards the clinic: englerins for kidney cancer and Ewings sarcoma, and schweinfurthins for CNS tumors and other NF1-dependent conditions. These natural products both have unique mechanisms of action. In addition, our group builds and maintains the library of chemical diversity with which the MTL conducts high throughput screening campaigns based on CCR-identified molecular targets.

Publications

Selected Publications
  1. Turbyville TJ, Gürsel DB, Tuskan RG, Walrath JC, Lipschultz CA, Lockett SJ, Wiemer DF, Beutler JA, Reilly KM.
    Mol. Cancer Ther.. 9: 1234-43, 2010. [ Journal Article ]
  2. Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.
    Org. Lett.. 11: 57-60, 2009. [ Journal Article ]
  3. Boyd MR, Farina C, Belfiore P, Gagliardi S, Kim JW, Hayakawa Y, Beutler JA, McKee TC, Bowman BJ, Bowman EJ.
    J Pharmacol Exp Ther. 297: 114-20, 2001. [ Journal Article ]
  4. Beutler JA, Shoemaker RH, Johnson T, Boyd MR.
    J. Nat. Prod.. 61: 1509-12, 1998. [ Journal Article ]
  5. Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee M, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L.
    Cancer Cell. 23: 228-37, 2013. [ Journal Article ]

Biography

BA Chemistry, Vassar College 1972 MSc Phila College of Pharmacy & Science 1978 PhD Phila College of Pharmacy & Science 1980 Postdoctoral Fellowships Northeastern University 1980-1 Assistant Professor, Auburn University School of Pharmacy 1981-1983 University of Texas Medical School at Houston 1983-4

Team

Name Position
Jason R. Evans Programmer / Analyst (Contr)
Ekaterina I. Goncharova Ph.D. Programmer / Analyst (Contr)
Cheryl Thomas B.S. Research Chemist