John A. Beutler, Ph.D.
John A. Beutler, Ph.D.
Associate Scientist
Head, Chemical Diversity Development Section

Dr. Beutler has identified several natural products which have potential for development as cancer drugs, among them, englerins, which are in preclinical development for kidney cancer and Ewing’s sarcoma, schweinfurthins, which are preclinical candidates in glioblastoma and malignant peripheral nerve sheath tumors, and salicylihalamides, of interest in sarcomas. As a staff scientist, Dr. Beutler oversees the Lab's high-throughput screening libraries, information technology, and drug development efforts.

Areas of Expertise
1) natural products chemistry, 2) high-throughput screening, 3) molecular pharmacology

Contact Info

John A. Beutler, Ph.D.

Center for Cancer Research
National Cancer Institute

Building 560-1, Room 11-86
Frederick, MD 21702-1201
301-846-1942

We are advancing two natural product projects towards the clinic: englerins for kidney cancer and Ewings sarcoma, and schweinfurthins for central nervous system (CNS) tumors and other NF1-dependent conditions. These natural products both have unique mechanisms of action.  In addition, our group builds and maintains the library of chemical diversity with which the Molecular Targets Laboratory conducts high-throughput screening campaigns based on CCR-identified molecular targets.

Scientific Focus Areas:
Chemical Biology, Molecular Pharmacology
Selected Key Publications
  1. Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee M, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L.
    Cancer Cell. 23: 228-37, 2013. [ Journal Article ]
  2. Turbyville TJ, Gürsel DB, Tuskan RG, Walrath JC, Lipschultz CA, Lockett SJ, Wiemer DF, Beutler JA, Reilly KM.
    Mol Cancer Ther. 9: 1234-43, 2010. [ Journal Article ]
  3. Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.
    Org Lett. 11: 57-60, 2009. [ Journal Article ]
  4. Boyd MR, Farina C, Belfiore P, Gagliardi S, Kim JW, Hayakawa Y, Beutler JA, McKee TC, Bowman BJ, Bowman EJ.
    J Pharmacol Exp Ther. 297: 114-20, 2001. [ Journal Article ]
  5. Beutler JA, Shoemaker RH, Johnson T, Boyd MR.
    J Nat Prod. 61: 1509-12, 1998. [ Journal Article ]

B.A., Chemistry, Vassar College, 1972
M.Sc., Philadelphia College of Pharmacy & Science, 1978
Ph.D., Philadelphia College of Pharmacy & Science, 1980

Postdoctoral Fellowships:
Northeastern University, 1980-1
Assistant Professor, Auburn University School of Pharmacy, 1981-1983
University of Texas Medical School at Houston, 1983-4

Name Position
Timothy Bostaph Programmer / Analyst (Contr)
Namki Cho Ph.D. Postdoctoral Fellow (Visiting)
Ekaterina Goncharova Ph.D. Programmer / Analyst (Contr)
Sarah Long Ph.D. Postbaccalaureate Fellow (CRTA)
Laila Salmen Espindola Ph.D. Special Volunteer
Cheryl Thomas B.S. Research Chemist

Research

We are advancing two natural product projects towards the clinic: englerins for kidney cancer and Ewings sarcoma, and schweinfurthins for central nervous system (CNS) tumors and other NF1-dependent conditions. These natural products both have unique mechanisms of action.  In addition, our group builds and maintains the library of chemical diversity with which the Molecular Targets Laboratory conducts high-throughput screening campaigns based on CCR-identified molecular targets.

Scientific Focus Areas:
Chemical Biology, Molecular Pharmacology

Publications

Selected Key Publications
  1. Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee M, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L.
    Cancer Cell. 23: 228-37, 2013. [ Journal Article ]
  2. Turbyville TJ, Gürsel DB, Tuskan RG, Walrath JC, Lipschultz CA, Lockett SJ, Wiemer DF, Beutler JA, Reilly KM.
    Mol Cancer Ther. 9: 1234-43, 2010. [ Journal Article ]
  3. Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.
    Org Lett. 11: 57-60, 2009. [ Journal Article ]
  4. Boyd MR, Farina C, Belfiore P, Gagliardi S, Kim JW, Hayakawa Y, Beutler JA, McKee TC, Bowman BJ, Bowman EJ.
    J Pharmacol Exp Ther. 297: 114-20, 2001. [ Journal Article ]
  5. Beutler JA, Shoemaker RH, Johnson T, Boyd MR.
    J Nat Prod. 61: 1509-12, 1998. [ Journal Article ]

Biography

B.A., Chemistry, Vassar College, 1972
M.Sc., Philadelphia College of Pharmacy & Science, 1978
Ph.D., Philadelphia College of Pharmacy & Science, 1980

Postdoctoral Fellowships:
Northeastern University, 1980-1
Assistant Professor, Auburn University School of Pharmacy, 1981-1983
University of Texas Medical School at Houston, 1983-4

Team

Name Position
Timothy Bostaph Programmer / Analyst (Contr)
Namki Cho Ph.D. Postdoctoral Fellow (Visiting)
Ekaterina Goncharova Ph.D. Programmer / Analyst (Contr)
Sarah Long Ph.D. Postbaccalaureate Fellow (CRTA)
Laila Salmen Espindola Ph.D. Special Volunteer
Cheryl Thomas B.S. Research Chemist