Additional Information

Sri Krishna, Ph.D. is a Research Fellow at Surgery Branch. His research drives the basic and translational research efforts on understanding human tumor immunology and leveraging this understanding to develop next-generation cellular immunotherapies against cancer. Dr. Krishna’s current research focuses on deciphering the cellular states that antitumor T cells can attain in metastatic solid tumors. To this end, he employs high-dimensional single cell genomic and proteomic analyses to understand antitumor, neoantigen-specific tumor-infiltrating T cell states in patients with metastatic cancer. These studies have identified human T cell phenotypic properties that are associated with cell therapy response (Krishna & Lowery  et al, Science, 2020) as well as uncovered the core transcriptomic signatures of neoantigen-specific T cells that can be utilized to genetically engineer T cell receptor (TCR) therapies against solid tumors (Lowery and Krishna et al, Science, 2022). Other ongoing studies by Dr. Krishna relate to understanding immune responses within solid epithelial tumors, ongoing efforts on rescuing human antitumor dysfunctional T cells, and deciphering molecular properties of immunogenic neoantigens in human cancers.

Areas of expertise:

1) T cell dysfunction 2) Immunotherapy 3) Adoptive Cell Therapy 4) Tumor Evolution 5) TCR Therapy