Top: HMGN Variants and Their Functional Domains. HMGNs bind to core particles through their NBD. The "core NBD" is invariant. Mutations in any of the red residues abolish the binding of HGMNs to chromatin. Bottom: HMGNs Bind to Nucleosome Core Particles But Not to DNA. Mutations in the Core-NBD abolish the interaction with core particles.