A representative schematic shows that PROTAC targeting or deletion of hRpn13 (purple) alters gene expression through hRpn13 interactions with epigenetic factors HDAC8 (orange), PADI4 (blue), and transcription factor NF-κB p50 (green) (Osei-Amponsa et al., Molecular Cell 84, 522-537, doi.org/10.1016/j.molcel.2023.11.035, (2024).