Breadcrumb

Molecular Discovery Seminar Series

All seminars are given at NCI-Frederick in Bldg 549 Auditorium on Thursdays at 10:00am, unless otherwise indicated.

Fall 2022 Series

Sep 08  Christina Woo (Harvard Univ)

Oct 20  Michelle Arkin (UCSF)

Oct 27  Emily Dykhuizen (Purdue Univ)
             This seminar will begin at 1:00pm

Nov 10  Jeff Hartgerink  (Rice Univ)
             This seminar will begin at 1:00pm

Nov 17  Ralph Kleiner (Princeton Univ)

Dec 01  Ellen Sletten (UCLA)
             This seminar will begin at 1:00pm

Dec 08  Abhishek Chatterjee (Boston College)


Spring 2022 Virtual Series

Jan 20  Jeffrey Hubbell (Univ of Chicago)
Engineering Cytokines for Retention and Activation in the Tumor Microenvironment”

Feb 03  Cesar de la Fuente (Univ of Pennsylvania)
“Machine Biology for Infectious Diseases”

Mar 31  Jason Sheltzer (Yale School of Medicine)
“Uncovering the True Targets of Mischaracterized Anti-Cancer Agents”

Apr 07* Phoebe Glazer (Univ of Kentucky)
"Controlling Coordinative Bonds in Metallodrugs and Metallotargets for Medical Applications"
*Sponsored by the CBL Women in Chemistry

May 12  Eranthie Weerapana (Boston College)
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines"

May 19  Sara Buhrlage (Harvard Medical School)
"A DUB-Focused Chemical Biology Platform"

May 26  Stacy A. Malaker (Yale Univ)
"Revealing the Human Mucinome"

Jun 02  Ratmir Derda (Univ of Alberta)
"Probing Glycobiology in Vitro and in Vivo Using Genetically Encoded Liquid Glycan Arrays (LiGA)"


Fall 2021 Virtual Series

Oct 07   Dmitry Lyumkis (The Salk Institute)
“Structural Biology and Inhibition of HIV Integration”

Oct 21   Yi Tang (UCLA)
"Nature Product Discovery from Fungi in the Genomic Era"

Oct 28   Daniel Bachovchin (Sloan Kettering Institute)
"Activation of the NLRP1 and CARD8 Inflammasomes"

Nov 04   Christos A Nicolaou (Eli Lilly & Co)
"Advancing Automated Synthesis: Designing Actionable Routes"

Nov 18   Greg Thurber (Univ of Michigan)
"Imaging and Computational Tools to Usher in the Next Wave of Antibody Drug Conjugate Approvals"

Dec 02   Monika Raj (Emory Univ)
"Chemical Tools to Study Biological Systems"


Spring 2021 Virtual Series

Feb 25   Summer Gibbs (Oregon Health & Science Univ)
"Can Near Infrared Nerve-Specific Fluorophores Improve Surgical Outcomes?"
This seminar will be at 1:00pm

Mar 04   Meritxell Teixidó (IRB Bareclona)
"Gate2brain, opening the gate to CNS"

Mar 11   Katharina Ribbeck (MIT)
"Partners in Slime: How Mucus Regulates Microbial Virulence"

Mar 18   Yael David (Memorial Sloan Kettering Cancer Center)
"Uncovering Cancer-Associated Epigenetic Events Using Novel Chemical Tools"

Apr 08   Aaron Esser-Kahn (Univ of Chicago)
"Discovery of Molecular Activators of Innate Immunity for Cancer & Infectious Disease"

Apr 15   Christian Friedrich Wilhelm Becker (Univ of Vienna)
"Controlling Self-Assembly of Peptides involved in Biomimetic Silica Formation"

Apr 22   Christoph Rademacher (Max Planck Institute)
"Small Molecule Modulators of C-type Lectin Receptor Functions"

Apr 29   Erick Strauss (Stellenbosch Univ)
“From Nootropic to CoA Inhibitor: Unraveling the Mechanism of Action of the Pantothenate Analog Hopantenate (HoPan)"

May 13   Tim Bugni (Univ of Wisconsin)
“Metabolomics Driven Discovery of Small Molecules from Marine Bacteria”

May 20   Danica Fujimori (Univ of California, San Francisco)
“Chemical Biology of Reversible Chromatin Methylation”

May 27*   Lynne Regan (Univ of Edinburgh)
“The Design and Application of Protein Interactions – Inside and Outside the Cell”
*Sponsored by the CBL Women in Chemistry


Fall 2020 Virtual Series

Sep 17   Cliff Stains (Univ of Virginia)
"Chemical Approaches for Interrogating Cellular Processes"

Sep 24   Nir London (Weizmann Institute of Science)
“From covalent inhibitors to covalent PROTACs”

Oct 08   Alison Tebo (Janelia Research Campus)
“Imaging Cellular Processes Using Chemical-Genetic Tools”

Oct 22   Christian Olsen (Univ of Copenhagen)
"Cyclic Peptides for Investigating Histone Deacetylase (HDAC) Enzymes and Bacterial Communication"

Oct 29*   Christine Szymanski (Univ of Georgia)
"Exploiting Protein N-glycosylation in Campylobacter"
*Sponsored by the CBL Women in Chemistry

Nov 12   Dorothea Fiedler (FMP-Berlin)
"Inositol Pyrophosphates – Multimodal Messengers Interrogated with Chemical Tools”

Nov 19   Rob Batey (Univ of Colorado)
"Small molecule-RNA interactions from biology to application"

Dec 03   Elisa Fadda (Maynooth Univ)
"Functional role of the glycan shield in the activation of the SARS-CoV-2 S protein”


Spring 2020 Virtual Series

Apr 02   Lingyin Li (Stanford Univ)
“Understand the extracellular cGAMP-STING pathway and harness it to treat cancers”

May 28   Christian P. R. Hackenberger (Humboldt Univ and FMP-Berlin)
“The power of chemoselectivity: Functional protein-conjugates for intra- and extracellular targeting”

Jun 04   Ali Tavassoli (Univ of Southampton)
“Platforms for the generation and high-throughput screening of cyclic peptide libraries”

Jun 11   Alison Narayan (Univ of Michigan)
“Biocatalysis and complex molecule synthesis”

Jun 18   Jeremy M. Baskin (Cornell University)
“Chemical Tools that IMPACT Lipid Signaling”


Spring 2020

All seminars are given at NCI-Frederick in Bldg 549 Auditorium on Thursdays at 10:00am.

Jan 23   Jaclyn Winter (Univ of Utah)
"Developing Microorganisms for Drug Discovery"

Feb 13   Brian Shoichet (Univ of California, San Francisco)
"Docking >500 million available molecules to discover new chemotypes with new biology"


Fall 2019

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Sep 12   Ron Raines (MIT)
"Ghost Proteins"

Sep 26   Yamuna Krishnan (Univ of Chicago)
“Quantitative Chemical Imaging in Live Cells”

Oct 03   Robert Cichewicz (Univ of Oklahoma)
“Seeking the Forest for the Trees: Finding Patterns and Chemistry Encompassing 3,531,905 Square Miles of Fungal Habitat”

Oct 10   Doug Johnson (Biogen)
“Application of Chemical Biology Probes and Bioorthogonal Chemistry in Drug Discovery”

Oct 24   Bobby Arora (New York Univ)
"Rational Design Strategies for Targeting Protein-Protein Interactions in Cancer"

Nov 07   Michael Cohen (Oregon Health & Science Univ)
“Decoding Protein ADP-ribosylation Networks in Cells Using Chemistry-based Approaches"

Nov 21   Eric Strieter (UMass-Amherst)
"Uncovering the Cryptic Functions of a Deubiquitinase"

Dec 05*   Kristi Kiick (Univ of Delaware)
"Phase-Separating (POLY)Peptides in the Design of Advanced Biomaterials"
*Sponsored by the CBL Women in Chemistry

Dec 12   Mano Manoharan (Alnylam Pharmaceuticals)
“Biometric Chemistry of Human RNAi Therapeutics”


Spring 2019

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Mar 07   Miguel Castanho (Univ of Lisbon, Portugal)
“Membrane-targeting peptides: from antimicrobial to anticancer”

Mar 21   Dirk Trauner (New York Univ)
"Controlling Protein Levels and Function with Photopharmacology"

Apr 04   Eric Kool (Stanford Univ)
“Small Molecules for Study and Control of RNA”

Apr 25   Rahul Kohli (Univ of Pennsylvania)
“Capturing TET-mediated DNA demethylation in action”

May 09   Dehua Pei (The Ohio State Univ)
“Drugging “Undruggable” Targets with Macrocyclic Peptides”

May 23   Kai Johnsson (Max Planck Institute)
"Fluorescent and Bioluminescent Sensor Proteins"

May 30   Hendrik Luesch (Univ of Florida)
"Natural Products from Marine Cyanobacteria as Starting Points for Drug Discovery and Development"


Fall 2018

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Sep 20   Rick Wagner (University of Minnesota)
"Non-Genetic Engineering of Cell-Cell Interactions for Cancer Immunotherapy and Beyond"

Sep 27   Lou Charkoutian (Haverford University)
“Capturing transient interactions of proteins involved in natural product biosynthesis”

Oct 04   Jen Heemstra (Emory University)
“Small-molecule detection and enantiopurity measurement using DNA-based sensors”

Oct 25   Mary Kay Pflum (Wayne State University)
"Histone Deacetylase Proteins: Inhibitor Design and Substrate Identification"

Nov 08*   Laura Kiessling (Massachusetts Institute of Technology)
“Probes of Dendritic Cell Lectins”
*Sponsored by the CBL Women in Chemistry

Nov 29   Kamil Godula (University of California, San Diego)
“Chemical tools for tailoring glycan interactions at the cell-matrix interface”

Dec 06   Sarah Slavoff (Yale University)
"Translation and functions of small open reading frames"

Dec 13   Marcy Waters (University of North Carolina)
“New Tools for Studying Epigenetic Protein-Protein Interactions”


Spring 2018

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Feb 15   Minkui Luo (Memorial Sloan Kettering Cancer Center)
"Chemical Interrogation of Protein Methyltransferases: Function, Inhibition and Mechanism”

Mar 01   Michelle Arkin (Univ of California, San Francisco)
"Tackling Challenging Drug Targets, a Biophysical Perspective"

Apr 19  Karen Wooley (Texas A&M Univ)
"Expanding the Scopes of Synthetic Organic and Polymer Chemistry"

May 03   Matt Francis (Univ of California, Berkeley)
"New Synthetic Tools for Making Protein-Based Material"

May 10   Nadja Cech (Univ of NC at Greensboro)
“Untargeted metabolomics to Identify Bioactive Natural Products: Getting from What’s here? to What matters?"

May 31   David Chenoweth (Univ of Pennsylvania)
"Design and synthesis of new chemical tools for probing, manipulating, and imaging biological systems"


Fall 2017

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Sep 14   Brian Bachmann (Vanderbilt Univ)
"Discovery of primary tumor cell selective effector molecules using single cell multiplexed activity metabolomics"

Sep 21   Sam Achilefu (Washington Univ in St. Louis)
“Light-Mediated Cancer Imaging and Treatment”

Oct 05  M.G. Finn (Georgia Tech)
“Click Reactions and Protein Nanoparticles: Building Functional Structures with Chemistry and Molecular Biology”

Nov 02   Sid Hecht (Arizona State Univ)
“Protein synthesis with Non-proteinogenic Alpha and Non-alpha Amino Acids”

Nov 09   Catherine Leimkuhler Grimes (Univ of Delaware)
"Breaking down Bacterial Cell Walls to Understand Inflammation"

Nov 16   John Denu (Univ of Wisconsin, Madison)
"How Metabolism Informs the Epigenome"

Nov 30   Paola Castaldi (AstraZeneca)
“Chemical Biology Strategies Applied to Drug Discovery”

Dec 07   Bing Xu (Brandeis Univ)
“Enzyme-Instructed Peptidic Nanostructures for Selectively Inhibiting Cancer Cells”


Spring 2017

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Jan 12   Dustin Maly (Univ of Washington)
“Allosteric Modulation of Protein Kinases with Small Molecule Inhibitors”

Mar 23   Michael Rossmann (Purdue Univ)
“The Structure of Zika Virus”

Mar 30   Alexei Demchenko (Univ of Missouri, St Louis)
“From Stereocontrolled Glycosylation to the Automated Oligosaccharide Synthesis”

Apr 13   Ting Xu (Univ of California, Berkeley)
“Toward Protein/Peptide-based Functional Hybrid Materials”

Apr 20   Dennis Dougherty (California Institute of Technology)
“High-Precision Studies of Drug-Receptor Interactions in the Nicotinic Receptor”

Apr 27   Steven Zimmerman (Univ of Illinois, Urbana)
Targeting the DNA and RNA That Causes Disease Using Small Molecules and Polymers”

May 04   Eric Schmidt (Univ of Utah)
“Accessing novel structural and bioactivity classes of marine natural products”

May 11   Chris Vanderwal (Univ of California, Irvine)
“Synthesis Strategies to Address Bioactive Natural Product Families”


Fall 2016

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Sep 8   Phil Cole (Johns Hopkins Univ)
"Bivalent Approaches to Drug Discovery"

Sep 29   Bruce Armitage (Carnegie Mellon Univ)
“Fluorescence Imaging Reagents Based on RNA Aptamers, Synthetic Polymers and Fluorogenic Cyanine Dyes”

Oct 6   Mark Distefano (Univ of Minnesota)
“Protein Lipid Modification: New Chemistry and New Biology”

Oct 20   Gary Martin (Merck)
“Evolving NMR Capabilities: The Impact on What is Possible”

Oct 27   Bradley Smith (Univ of Notre Dame)
“Near-infrared Fluorescent Multivalent Molecular Probes for Biological Imaging”

Nov 3   Danzhou Yang
“Structure and Function of DNA G-quadruplexes and Its Potential as Anticancer Drug Target”

Nov 10   John Magnani (GlycoMimetics)
“The design, evaluation and clinical development of novel glycomimetic drugs for inflammatory disease and cancer”

Nov 17   Dustin Maly (Univ of Washington)
“Allosteric Modulation of Protein Kinases with Small Molecule Inhibitors”

Dec 8   Eric Martin (Novartis)
"Profile-QSAR Gen 2: Deep learning Kinase IC50 predictions for novel compounds as accurate as 4-pt IC50s"


Spring 2016

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Jan 21   Michael Strano (Massachussetts Inst of Technology)
“Fluorescent Carbon Nanotube Sensor Arrays and CoPhMoRe Binding for Label Free Glycoprofiling”

Feb 18   Richard Houghten (Torrey Pines Inst for Molecular Studies)
“The Direct Phenotypic Screening in Mice Using Large and Chemically Diverse Combinatorial Libraries”

Mar 10   Ben Miller (Univ of Rochester)
“Altering Protein Recording with Synthetic RNA Binders in HIV and Beyond”

Mar 31   Alex Deiters (Univ of Pittsburgh)
“Optical Control of Biological Processes in Cells and Animals”

Apr 14   Dennis Discher (Univ of Pennsylvania)
“Macrophage Recognition of ‘Self’ for Nano-and Micro- applications against solid Tumors"

Apr 21   Susan Mooberry (Univ of Texas Health Science Center, San Antonio)
“Looking to Nature to Discover Effective Treatments for Triple Negative Breast Cancers”

May 12   Kwaku (Theodore) Dayie (Univ of Maryland)
"Custom Made Nucleotides for RNA NMR"


Fall 2015

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Sep 10   Rob Britton (Simon Fraser Univ)
“New Reactions and Strategies for Natural Product and Drug Synthesis”

Oct 8   David Piwnica-Worms (MD Anderson Cancer Ctr)
“Molecular Imaging Strategies for Dynamic High Throughput Screens”

Oct 15   Linda Baum (Univ of Cal – Los Angeles)
“Assembly of Glycan-lectin Lattices Creates Functional Microdomains on the Cell Surface”

Nov 5   Yitzhak Tor (Univ of Cal – San Diego)
“New Isomorphic Fluorescent Nucleosides for Studying RNA-based Processes”

Nov 19   Linda Hsieh Wilson (Cal Inst of Tech)
“Carbohydrate Signaling in Neurobiology and Cancer”

Dec 10   Kevin Gardner (City University of New York)
“Environmentally-controlled protein/protein interactions: Nature’s switches, scientists’ tools”


Spring 2015

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Jan 22   Glenn Prestwich (University of Utah)
"Clinical Biomaterials for Regenerative Medicine: From Bench to Business to Bedside"

Feb 5   Heran Darwin (New York University)
"Mycobacterium tuberculosis, proteasomes, pupylation and... plant hormones?"

Feb 12   Paul Thompson (University of Massachusettes Medical School)
"Picking the PADlock: Chemical Probes to Characterize PAD Biology"

Feb 26   Sean Brady (Rockefeller University)
"Watch where you step, there is new chemistry everywhere"

Mar 19   Patricia Clark (University of Notre Dame)
"Synonymous Codon Substitutions: Not So 'Silent' After All"

Apr 16   Sandra Lee (Merck, Inc)
"Discovery of Novel, Selective Spleen Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis"

Apr 23   Klaus Hahn (University of North Carolina – Chapel Hill)
"Protein engineering to image and control Rho family GTPase signaling in motility"

May 14   Paul Hergenrother (University of Illinois, Urbana-Champaign)
"Anticancer drug discovery, from simple and complex compounds"


Fall 2014

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Sep 18   James Bradner (Harvard Medical School/Dana Farber Cancer Institute)
"Chemical Modulation of Chromatin Structure and Function"

Oct 2   Roger Linington (University of California, Santa Cruz)
"Connecting Phenotype and Chemotype: Development of an Integrated Platform for the Direct Prediction of Natural Products Mode of Action"

Oct 16   Jianghong Rao (Stanford University)
"A biocompatible condensation reaction between cyanobenzothiazole and aminothiol and its application for molecular imaging"

Oct 23   Jen Prescher (University of California, Irvine)
"Expanding the imaging toolbox"

Oct 30   Milan Mrksich (Northwestern University)
"Combining Arrays and Mass Spectrometry for High Throughput Discovery in Biology"

Nov 13   Joel Collier (University of Chicago)
"Supramolecular Peptide Immunomodulators"

Nov 20   Samie Jaffrey (Cornell University)
"Imaging RNA and RNA biology using RNA mimics of green fluorescent protein"

Dec 4   Amy Rosenzweig (Northwestern University)
"Copper, natural products, and biological methane oxidation"


Spring 2014

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Mar 27   Luke Lavis (HHMI-Janelia Farms)
“Old Dyes, New Tricks: Building Better Fluorophores for Biology”

Apr 10   John Porco (Boston University)
“Chemical Synthesis and Biological Studies of Antitumor Natural Products”

Apr 24   Gregg Fields (Torrey Pines Inst. For Molecular Studies)
“Modulation of Cell Surface Proteolytic Activity”

May 1   Gary Sulikowski (Vanderbilt University)
“Synthesis and Study of Natural Products of Possible Relevance to Human Health”

May 15   Judith Frydman (Stanford University)
“Chaperone control of cellular proteostasis in health and disease”

May 29   Hening Lin (Cornell University)
“Sirtuins and novel protein posttranslational modifications”

June 5   Ron Schnaar (Johns Hopkins University)
“Glycan Recognition in the Control of Inflammation”


Fall 2013

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Oct 24   Magid Abou-Gharbia (Temple University)
“Discovery of innovative therapeutics: Today’s realities and tomorrow’s vision”

Nov 7   John MacMillan (UT Southwestern Medical Center)
“Integration of microbial natural products with high-content screening for cancer drug discovery”

Nov 14   Sam Gellman (University of Wisconsin)
“Mimicry of Protein Surfaces with Alpha/Beta-Peptide Foldamers”

Nov 21   David Fushman (University of Maryland)
“Deciphering the “Ubiquitin Code”: Synthesis and Structure-Function Analysis of Non-Canonical Polyubiquitin Chains”

Dec 5   Tom Kodadek (The Scripps Research Institute - Florida)
“Chemical Tools to Monitor and Manipulate the Proteome”

Dec 12   Anna Mapp (University of Michigan)
“Small Molecule Transcriptional Modulators”

Dec 19   Ryan Looper (University of Utah)
“New methods to access biomedically interesting guanidinium ion scaffolds”


Spring 2013

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Jan 31   Justin DuBois (Stanford University)
"Turning Toxins into Tools for the Study of Ion Channels"

Feb 21   Thomas Williamson (Merck, Inc)
"ADEQUATE: NMR Experiments With an Expanding Role in Structure Elucidation"

Apr 4   Angela Koehler (The Broad Institute)
“Small-molecule probe discovery for transcriptional regulators”

May 2   Chris Lima (MSKCC)
“Structural insights to post-translational modification by Ubiquitin and Ubiquitin-like proteins”

May 23   Jeff Aube (University of Kansas)
“Chemical Probes”

May 30   Jon Thorson (University of Kentucky)
"New strategies and tools for natural product diversification and discovery"


Fall 2012

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Aug 23   Julia Kornfield (Cal Tech)
"Crosslinking of Ocular Tissues"

Sep 20   Ron Koder (City College NY)
"Protein Design Approaches to Cancer Therapies"

Oct 4   Bill Gerwick (UCSD - SIO)
"The Fabulous Natural Products of Marine Cyanobacteria: Structures, Biological Activities, Biosynthetic Pathways"

Nov 8   Derek Tan (MSKCC)
"Diversity and Design: New Chemical Probes for Biology and Medicine"

Dec 13   David Spiegel (Yale University)
“Using Small Molecules to Engineer and Explore Human Immunity”


Spring 2012

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am, unless otherwise noted.

Mar 1   John Toscano (Johns Hopkins University)
"Nitroxyl (HNO): Nitric Oxide's Neglected Sibling"

Mar 12*   Jim Wells (UCSF)
"Challenging Targets: Reaching for High Hanging Fruit in Drug Discovery"
*Please note: This seminar is on MONDAY

Apr 5   Phil Dawson (TSRI)
"Chemical Ligation: From Post-Translationally Modified Proteins to Nanoparticle Engineering"

Apr 19   Paul Hanson (University of Kansas)
"Phosphate-Tether Mediated Methods to Bioactive Natural Products and Analogs"

May 3   David Lawrence (UNC at Chapel Hill)
"Cells Are Poor Cuvette Models: Challenges and Prospects of Molecular Probes for Intracellular Biochemistry"

May 24   Peter Wipf (University of Pittsburgh)
"In Search of the Silver Bullet- Redefining the Academic Drug Discovery Trajectory"


Fall 2011

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am, unless otherwise noted.

Sep 15   Ted Molinski (UCSD)
"Marine Natural Products. Scope, Synthesis-Aided Discovery, and New Approaches"

Oct 6   Ben Shen (Scripps Florida)
"Natural Products Drug Discovery: Challenges and Opportunities"

Oct 13   Hai-Quan Mao (Johns Hopkins University)
"Controlled Condensation of DNA and Self-Assembled Polymer/DNA Micelles for Liver-Targeted Gene Delivery"

Nov 3   Carlito Lebrilla (UC - Davis)
"Quantitative Measurements of Protein Glycosylation in Diseases and Health"

Nov 10   Cheryl Arrowsmith (University of Toronto)
"Structural and Chemical Biology of Readers and Writers of the Histone Code"

Nov 17   Matt Bogyo (Stanford University)
"Probing Protease Function Using Small Molecules: Applications from Cancer to Malaria"

Dec 1*   Kylie Walters (University of Minnesota)
"Targeting Proteins for Destruction"
*Please note: This seminar will be at 11am instead of 10am.


Spring 2011

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Jan 20   Jiyong Hong (Duke University)
"Natural Product Synthesis at the Interface of Chemistry and Biology"

Feb 3   Chris Ireland (University of Utah)
"Antitumor Agents from Marine Organisms"

Feb 24   Matt Francis (University of California, Berkeley)
"New Chemical Methods for Site Selective Protein Modification"

Mar 24   Dan Kahne (Harvard University)
"How does a cell make more of itself"

Apr 14   Brad Moore (University of California, San Diego/Scripps Institution of Oceanography)
"Genomics-inspired Discovery and Bioengineering of Natural Product Drugs"

May 5   Darrell Irvine (Massachusetts Institute of Technology)
"New materials and new methods for cancer immunotherapy and vaccine delivery"

May 19   Bruce Yu (University of Maryland)
"Developing Imaging Agents for 19F MRI"


Fall 2010

All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.

Aug 19   Pieter Dorrestein (University of California, San Diego)
"Translating Adaptive Metabolism with Imaging Mass Spectrometry"

Sept 9   Peter Andreana (Wayne State University)
"Targeting Cellular Immunity with Entirely Carbohydrate-based Constructs"

Sept 16   David Corey (University of Texas Southwest Medical Center)
"Controlling Gene Expression with Synthetic Nucleic Acids"

Oct 7   Scott Miller (Yale University)
"Diverse Peptide-Based Catalysis for Diversification of Biologically Interesting Scaffolds"

Oct 21   Don Engleman (Yale University)
"pH-Dependent Transmembrane Peptide Insertion: Mechanism and Uses in Drug Delivery and Tumor Imaging"

Nov 18   Henry Kopecek (University of Utah)
"Smart Biomaterials and Drug Delivery Systems"