All seminars are given at NCI-Frederick in Bldg 549 Auditorium on Thursdays at 11:00am, unless otherwise indicated.
Fall 2024 Series
Nov 14 Dennis Bong (The Ohio State Univ)
“Cell Penetrating Bifacial Peptide Nucleic Acids (bPNAs) Can Target Intracellular RNAs”
Nov 21 Christopher Chang (Princeton Univ)
"Activity-Based Sensing: Leveraging Selective Chemical Reactivity to Decipher Biology at the Atomic Scale”
Dec 5 Brian Dickinson (The Univ of Chicago)
"Accelerating Binder and Glue Discovery Through Rapid in Vivo Selection”
Dec 12 Matthew Pratt (Univ of Southern California)
"Build it to Understand it: Synthesis to O-GlcNAc Modified Proteins”
Spring 2024 Series
Feb 22 Dan Nomura (UC Berkeley)
"Reimagining Druggability using Chemoproteomic Platforms"
Mar 14 Brent Iverson (UT Austin)
“Anthrax To COVID: A Protein Engineering Journey”
Mar 28 Akif Tezcan (UCSD)
“Chemical Design of Functional Protein Assemblies”
Apr 11 Mamuka Kvaratskhelia (Univ Colorado)
“Expect the Unexpected: Allosteric Inhibitors of HIV-1 Integrase and Capsid”
*This seminar is virtual only
Apr 25 Lu Wei (Caltech)
“Functional Bond-Selective Microscopy for Subcellular Bioanalysis”
May 23 Aseem Ansari (St. Jude)
"Chemical Control of Genes”
*This seminar is at 3pm
May 30 Julie Biteen (Univ Michigan)
“Determining the Nature of Interactions and Biomolecular Condensates in Microbes”
*Sponsored by the CBL Women in Chemistry
Jun 6 Mia Huang (Scripps Research)
"Taming Glycoconjugate Structure and Interactions in Development and Disease”
Fall 2023 Series
Sep 14 Neel Shah (Columbia Univ)
"Sequence Space Exploration in Phosphotyrosine Signaling Proteins”
Sep 21* Ryan Potts (Amgen)
"Next Generation Drug Discovery: Induced Proximity Medicines”
*This seminar is at 2pm
Sep 26* Nadine Samara (NIDCR, NIH)
“Evolution of the Diverse Substrate Specificities of Mucin-Type O-Glycosyltransferases (GalNAc-Ts) From Pathogen to Host”
*This seminar is on Tuesday at 10am
Oct 19 Sandra Loesgen (Univ Florida)
"Bioactive Natural Products from Unique Ecosystems and Behavior Guided Assays"
*This seminar is on Tuesday at 11am
Oct 26 Olexandr Isayev (Carnegie Mellon Univ)
"Assisting CADD with Machine Learning and AI”
Nov 09 Blake Peterson (Ohio State Univ)
"Fluorescent Probes of Engagement of Drug Targets by Small Molecules in Living Cells”
Nov 30* Alan Engelman (Harvard Univ)
"Sequence Space Plasticity of HIV Integrase Inhibitors”
*This seminar is virtual only
Dec 07* Linda Hsieh-Wilson (Cal Inst Tech)
"Decoding Glycosaminoglycan-Protein Interactions and Their Roles in Neuroplasticity”
*Sponsored by the CBL Women in Chemistry
Spring 2023 Series
Jan 12 Rein Ulijn (CUNY)
"Design and Discovery of Peptide-Based Nanofilaments and Condensates for Biomedical Applications"
Jan 26 Andrea Rentmeister (Univ Münster)
"Optical Control of mRNA Translation"
Mar 09 Caroline Proulx (NC State)
"New methods for the chemoselective functionalization of peptides”
Apr 20 Adam Renslo (UCSF)
"Harnessing Fenton-type Reactivity for Imaging, Chemoproteomics, and Drug Discovery"
May 10* Jeanne Hardy (UMass Amherst)
"Inhibition and Delivery of Native and Engineered Caspases Tuned to Cellular Properties”
*This seminar is on Wednesday
Jun 21* Jennifer Prescher (Univ California - Irvine)
"Imaging Tools and Technologies Inspired by Nature’s Light-emitting Chemistry”
*This seminar is on Wednesday
Jun 22 Christian Becker (Univ Vienna)
“Chemoselective Chemistries to Generate Modified Peptides and Proteins”
Fall 2022 Series
Sep 08 Christina Woo (Harvard Univ)*
"Chemical Biology Studies of the Thalidomide Binding Domain of Cereblon”
*This seminar will be virtual.
Oct 20 Michelle Arkin (UCSF)
"Stabilizing protein conformations and protein complexes with drug-like molecules”
Oct 27 Emily Dykhuizen (Purdue Univ)
"The Development of Chemical Probes for Histone “Reader” Subunits of Chromatin Remodeling Complexes”
*This seminar will begin at 1:00pm
Nov 10 Jeff Hartgerink (Rice Univ)
“Self-assembling Nanofibrous MultiDomain Peptides: Applications in Tissue Regeneration and Drug Delivery”
*This seminar will begin at 1:00pm
Nov 17 Ralph Kleiner (Princeton Univ)
“Illuminating RNA Biology with Metabolically Incorporated Ribonucleoside Probes”
Dec 01 Ellen Sletten (UCLA)
“Harnessing the Bioorthogonality of Fluorine to Advance Biomaterials”
*This seminar will begin at 1:00pm
Dec 08 Abhishek Chatterjee (Boston College)
“Genetically Encoded Chemistries to Read and Write Biology”
Spring 2022 Virtual Series
Jan 20 Jeffrey Hubbell (Univ of Chicago)
“Engineering Cytokines for Retention and Activation in the Tumor Microenvironment”
Feb 03 Cesar de la Fuente (Univ of Pennsylvania)
“Machine Biology for Infectious Diseases”
Mar 31 Jason Sheltzer (Yale School of Medicine)
“Uncovering the True Targets of Mischaracterized Anti-Cancer Agents”
Apr 07* Phoebe Glazer (Univ of Kentucky)
"Controlling Coordinative Bonds in Metallodrugs and Metallotargets for Medical Applications"
*Sponsored by the CBL Women in Chemistry
May 12 Eranthie Weerapana (Boston College)
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines"
May 19 Sara Buhrlage (Harvard Medical School)
"A DUB-Focused Chemical Biology Platform"
May 26 Stacy A. Malaker (Yale Univ)
"Revealing the Human Mucinome"
Jun 02 Ratmir Derda (Univ of Alberta)
"Probing Glycobiology in Vitro and in Vivo Using Genetically Encoded Liquid Glycan Arrays (LiGA)"
Fall 2021 Virtual Series
Oct 07 Dmitry Lyumkis (The Salk Institute)
“Structural Biology and Inhibition of HIV Integration”
Oct 21 Yi Tang (UCLA)
"Nature Product Discovery from Fungi in the Genomic Era"
Oct 28 Daniel Bachovchin (Sloan Kettering Institute)
"Activation of the NLRP1 and CARD8 Inflammasomes"
Nov 04 Christos A Nicolaou (Eli Lilly & Co)
"Advancing Automated Synthesis: Designing Actionable Routes"
Nov 18 Greg Thurber (Univ of Michigan)
"Imaging and Computational Tools to Usher in the Next Wave of Antibody Drug Conjugate Approvals"
Dec 02 Monika Raj (Emory Univ)
"Chemical Tools to Study Biological Systems"
Spring 2021 Virtual Series
Feb 25 Summer Gibbs (Oregon Health & Science Univ)
"Can Near Infrared Nerve-Specific Fluorophores Improve Surgical Outcomes?"
This seminar will be at 1:00pm
Mar 04 Meritxell Teixidó (IRB Bareclona)
"Gate2brain, opening the gate to CNS"
Mar 11 Katharina Ribbeck (MIT)
"Partners in Slime: How Mucus Regulates Microbial Virulence"
Mar 18 Yael David (Memorial Sloan Kettering Cancer Center)
"Uncovering Cancer-Associated Epigenetic Events Using Novel Chemical Tools"
Apr 08 Aaron Esser-Kahn (Univ of Chicago)
"Discovery of Molecular Activators of Innate Immunity for Cancer & Infectious Disease"
Apr 15 Christian Friedrich Wilhelm Becker (Univ of Vienna)
"Controlling Self-Assembly of Peptides involved in Biomimetic Silica Formation"
Apr 22 Christoph Rademacher (Max Planck Institute)
"Small Molecule Modulators of C-type Lectin Receptor Functions"
Apr 29 Erick Strauss (Stellenbosch Univ)
“From Nootropic to CoA Inhibitor: Unraveling the Mechanism of Action of the Pantothenate Analog Hopantenate (HoPan)"
May 13 Tim Bugni (Univ of Wisconsin)
“Metabolomics Driven Discovery of Small Molecules from Marine Bacteria”
May 20 Danica Fujimori (Univ of California, San Francisco)
“Chemical Biology of Reversible Chromatin Methylation”
May 27* Lynne Regan (Univ of Edinburgh)
“The Design and Application of Protein Interactions – Inside and Outside the Cell”
*Sponsored by the CBL Women in Chemistry
Fall 2020 Virtual Series
Sep 17 Cliff Stains (Univ of Virginia)
"Chemical Approaches for Interrogating Cellular Processes"
Sep 24 Nir London (Weizmann Institute of Science)
“From covalent inhibitors to covalent PROTACs”
Oct 08 Alison Tebo (Janelia Research Campus)
“Imaging Cellular Processes Using Chemical-Genetic Tools”
Oct 22 Christian Olsen (Univ of Copenhagen)
"Cyclic Peptides for Investigating Histone Deacetylase (HDAC) Enzymes and Bacterial Communication"
Oct 29* Christine Szymanski (Univ of Georgia)
"Exploiting Protein N-glycosylation in Campylobacter"
*Sponsored by the CBL Women in Chemistry
Nov 12 Dorothea Fiedler (FMP-Berlin)
"Inositol Pyrophosphates – Multimodal Messengers Interrogated with Chemical Tools”
Nov 19 Rob Batey (Univ of Colorado)
"Small molecule-RNA interactions from biology to application"
Dec 03 Elisa Fadda (Maynooth Univ)
"Functional role of the glycan shield in the activation of the SARS-CoV-2 S protein”
Spring 2020 Virtual Series
Apr 02 Lingyin Li (Stanford Univ)
“Understand the extracellular cGAMP-STING pathway and harness it to treat cancers”
May 28 Christian P. R. Hackenberger (Humboldt Univ and FMP-Berlin)
“The power of chemoselectivity: Functional protein-conjugates for intra- and extracellular targeting”
Jun 04 Ali Tavassoli (Univ of Southampton)
“Platforms for the generation and high-throughput screening of cyclic peptide libraries”
Jun 11 Alison Narayan (Univ of Michigan)
“Biocatalysis and complex molecule synthesis”
Jun 18 Jeremy M. Baskin (Cornell University)
“Chemical Tools that IMPACT Lipid Signaling”
Spring 2020
All seminars are given at NCI-Frederick in Bldg 549 Auditorium on Thursdays at 10:00am.
Jan 23 Jaclyn Winter (Univ of Utah)
"Developing Microorganisms for Drug Discovery"
Feb 13 Brian Shoichet (Univ of California, San Francisco)
"Docking >500 million available molecules to discover new chemotypes with new biology"
Fall 2019
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Sep 12 Ron Raines (MIT)
"Ghost Proteins"
Sep 26 Yamuna Krishnan (Univ of Chicago)
“Quantitative Chemical Imaging in Live Cells”
Oct 03 Robert Cichewicz (Univ of Oklahoma)
“Seeking the Forest for the Trees: Finding Patterns and Chemistry Encompassing 3,531,905 Square Miles of Fungal Habitat”
Oct 10 Doug Johnson (Biogen)
“Application of Chemical Biology Probes and Bioorthogonal Chemistry in Drug Discovery”
Oct 24 Bobby Arora (New York Univ)
"Rational Design Strategies for Targeting Protein-Protein Interactions in Cancer"
Nov 07 Michael Cohen (Oregon Health & Science Univ)
“Decoding Protein ADP-ribosylation Networks in Cells Using Chemistry-based Approaches"
Nov 21 Eric Strieter (UMass-Amherst)
"Uncovering the Cryptic Functions of a Deubiquitinase"
Dec 05* Kristi Kiick (Univ of Delaware)
"Phase-Separating (POLY)Peptides in the Design of Advanced Biomaterials"
*Sponsored by the CBL Women in Chemistry
Dec 12 Mano Manoharan (Alnylam Pharmaceuticals)
“Biometric Chemistry of Human RNAi Therapeutics”
Spring 2019
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Mar 07 Miguel Castanho (Univ of Lisbon, Portugal)
“Membrane-targeting peptides: from antimicrobial to anticancer”
Mar 21 Dirk Trauner (New York Univ)
"Controlling Protein Levels and Function with Photopharmacology"
Apr 04 Eric Kool (Stanford Univ)
“Small Molecules for Study and Control of RNA”
Apr 25 Rahul Kohli (Univ of Pennsylvania)
“Capturing TET-mediated DNA demethylation in action”
May 09 Dehua Pei (The Ohio State Univ)
“Drugging “Undruggable” Targets with Macrocyclic Peptides”
May 23 Kai Johnsson (Max Planck Institute)
"Fluorescent and Bioluminescent Sensor Proteins"
May 30 Hendrik Luesch (Univ of Florida)
"Natural Products from Marine Cyanobacteria as Starting Points for Drug Discovery and Development"
Fall 2018
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Sep 20 Rick Wagner (University of Minnesota)
"Non-Genetic Engineering of Cell-Cell Interactions for Cancer Immunotherapy and Beyond"
Sep 27 Lou Charkoutian (Haverford University)
“Capturing transient interactions of proteins involved in natural product biosynthesis”
Oct 04 Jen Heemstra (Emory University)
“Small-molecule detection and enantiopurity measurement using DNA-based sensors”
Oct 25 Mary Kay Pflum (Wayne State University)
"Histone Deacetylase Proteins: Inhibitor Design and Substrate Identification"
Nov 08* Laura Kiessling (Massachusetts Institute of Technology)
“Probes of Dendritic Cell Lectins”
*Sponsored by the CBL Women in Chemistry
Nov 29 Kamil Godula (University of California, San Diego)
“Chemical tools for tailoring glycan interactions at the cell-matrix interface”
Dec 06 Sarah Slavoff (Yale University)
"Translation and functions of small open reading frames"
Dec 13 Marcy Waters (University of North Carolina)
“New Tools for Studying Epigenetic Protein-Protein Interactions”
Spring 2018
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Feb 15 Minkui Luo (Memorial Sloan Kettering Cancer Center)
"Chemical Interrogation of Protein Methyltransferases: Function, Inhibition and Mechanism”
Mar 01 Michelle Arkin (Univ of California, San Francisco)
"Tackling Challenging Drug Targets, a Biophysical Perspective"
Apr 19 Karen Wooley (Texas A&M Univ)
"Expanding the Scopes of Synthetic Organic and Polymer Chemistry"
May 03 Matt Francis (Univ of California, Berkeley)
"New Synthetic Tools for Making Protein-Based Material"
May 10 Nadja Cech (Univ of NC at Greensboro)
“Untargeted metabolomics to Identify Bioactive Natural Products: Getting from What’s here? to What matters?"
May 31 David Chenoweth (Univ of Pennsylvania)
"Design and synthesis of new chemical tools for probing, manipulating, and imaging biological systems"
Fall 2017
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Sep 14 Brian Bachmann (Vanderbilt Univ)
"Discovery of primary tumor cell selective effector molecules using single cell multiplexed activity metabolomics"
Sep 21 Sam Achilefu (Washington Univ in St. Louis)
“Light-Mediated Cancer Imaging and Treatment”
Oct 05 M.G. Finn (Georgia Tech)
“Click Reactions and Protein Nanoparticles: Building Functional Structures with Chemistry and Molecular Biology”
Nov 02 Sid Hecht (Arizona State Univ)
“Protein synthesis with Non-proteinogenic Alpha and Non-alpha Amino Acids”
Nov 09 Catherine Leimkuhler Grimes (Univ of Delaware)
"Breaking down Bacterial Cell Walls to Understand Inflammation"
Nov 16 John Denu (Univ of Wisconsin, Madison)
"How Metabolism Informs the Epigenome"
Nov 30 Paola Castaldi (AstraZeneca)
“Chemical Biology Strategies Applied to Drug Discovery”
Dec 07 Bing Xu (Brandeis Univ)
“Enzyme-Instructed Peptidic Nanostructures for Selectively Inhibiting Cancer Cells”
Spring 2017
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Jan 12 Dustin Maly (Univ of Washington)
“Allosteric Modulation of Protein Kinases with Small Molecule Inhibitors”
Mar 23 Michael Rossmann (Purdue Univ)
“The Structure of Zika Virus”
Mar 30 Alexei Demchenko (Univ of Missouri, St Louis)
“From Stereocontrolled Glycosylation to the Automated Oligosaccharide Synthesis”
Apr 13 Ting Xu (Univ of California, Berkeley)
“Toward Protein/Peptide-based Functional Hybrid Materials”
Apr 20 Dennis Dougherty (California Institute of Technology)
“High-Precision Studies of Drug-Receptor Interactions in the Nicotinic Receptor”
Apr 27 Steven Zimmerman (Univ of Illinois, Urbana)
Targeting the DNA and RNA That Causes Disease Using Small Molecules and Polymers”
May 04 Eric Schmidt (Univ of Utah)
“Accessing novel structural and bioactivity classes of marine natural products”
May 11 Chris Vanderwal (Univ of California, Irvine)
“Synthesis Strategies to Address Bioactive Natural Product Families”
Fall 2016
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Sep 8 Phil Cole (Johns Hopkins Univ)
"Bivalent Approaches to Drug Discovery"
Sep 29 Bruce Armitage (Carnegie Mellon Univ)
“Fluorescence Imaging Reagents Based on RNA Aptamers, Synthetic Polymers and Fluorogenic Cyanine Dyes”
Oct 6 Mark Distefano (Univ of Minnesota)
“Protein Lipid Modification: New Chemistry and New Biology”
Oct 20 Gary Martin (Merck)
“Evolving NMR Capabilities: The Impact on What is Possible”
Oct 27 Bradley Smith (Univ of Notre Dame)
“Near-infrared Fluorescent Multivalent Molecular Probes for Biological Imaging”
Nov 3 Danzhou Yang
“Structure and Function of DNA G-quadruplexes and Its Potential as Anticancer Drug Target”
Nov 10 John Magnani (GlycoMimetics)
“The design, evaluation and clinical development of novel glycomimetic drugs for inflammatory disease and cancer”
Nov 17 Dustin Maly (Univ of Washington)
“Allosteric Modulation of Protein Kinases with Small Molecule Inhibitors”
Dec 8 Eric Martin (Novartis)
"Profile-QSAR Gen 2: Deep learning Kinase IC50 predictions for novel compounds as accurate as 4-pt IC50s"
Spring 2016
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Jan 21 Michael Strano (Massachussetts Inst of Technology)
“Fluorescent Carbon Nanotube Sensor Arrays and CoPhMoRe Binding for Label Free Glycoprofiling”
Feb 18 Richard Houghten (Torrey Pines Inst for Molecular Studies)
“The Direct Phenotypic Screening in Mice Using Large and Chemically Diverse Combinatorial Libraries”
Mar 10 Ben Miller (Univ of Rochester)
“Altering Protein Recording with Synthetic RNA Binders in HIV and Beyond”
Mar 31 Alex Deiters (Univ of Pittsburgh)
“Optical Control of Biological Processes in Cells and Animals”
Apr 14 Dennis Discher (Univ of Pennsylvania)
“Macrophage Recognition of ‘Self’ for Nano-and Micro- applications against solid Tumors"
Apr 21 Susan Mooberry (Univ of Texas Health Science Center, San Antonio)
“Looking to Nature to Discover Effective Treatments for Triple Negative Breast Cancers”
May 12 Kwaku (Theodore) Dayie (Univ of Maryland)
"Custom Made Nucleotides for RNA NMR"
Fall 2015
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Sep 10 Rob Britton (Simon Fraser Univ)
“New Reactions and Strategies for Natural Product and Drug Synthesis”
Oct 8 David Piwnica-Worms (MD Anderson Cancer Ctr)
“Molecular Imaging Strategies for Dynamic High Throughput Screens”
Oct 15 Linda Baum (Univ of Cal – Los Angeles)
“Assembly of Glycan-lectin Lattices Creates Functional Microdomains on the Cell Surface”
Nov 5 Yitzhak Tor (Univ of Cal – San Diego)
“New Isomorphic Fluorescent Nucleosides for Studying RNA-based Processes”
Nov 19 Linda Hsieh Wilson (Cal Inst of Tech)
“Carbohydrate Signaling in Neurobiology and Cancer”
Dec 10 Kevin Gardner (City University of New York)
“Environmentally-controlled protein/protein interactions: Nature’s switches, scientists’ tools”
Spring 2015
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Jan 22 Glenn Prestwich (University of Utah)
"Clinical Biomaterials for Regenerative Medicine: From Bench to Business to Bedside"
Feb 5 Heran Darwin (New York University)
"Mycobacterium tuberculosis, proteasomes, pupylation and... plant hormones?"
Feb 12 Paul Thompson (University of Massachusettes Medical School)
"Picking the PADlock: Chemical Probes to Characterize PAD Biology"
Feb 26 Sean Brady (Rockefeller University)
"Watch where you step, there is new chemistry everywhere"
Mar 19 Patricia Clark (University of Notre Dame)
"Synonymous Codon Substitutions: Not So 'Silent' After All"
Apr 16 Sandra Lee (Merck, Inc)
"Discovery of Novel, Selective Spleen Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis"
Apr 23 Klaus Hahn (University of North Carolina – Chapel Hill)
"Protein engineering to image and control Rho family GTPase signaling in motility"
May 14 Paul Hergenrother (University of Illinois, Urbana-Champaign)
"Anticancer drug discovery, from simple and complex compounds"
Fall 2014
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Sep 18 James Bradner (Harvard Medical School/Dana Farber Cancer Institute)
"Chemical Modulation of Chromatin Structure and Function"
Oct 2 Roger Linington (University of California, Santa Cruz)
"Connecting Phenotype and Chemotype: Development of an Integrated Platform for the Direct Prediction of Natural Products Mode of Action"
Oct 16 Jianghong Rao (Stanford University)
"A biocompatible condensation reaction between cyanobenzothiazole and aminothiol and its application for molecular imaging"
Oct 23 Jen Prescher (University of California, Irvine)
"Expanding the imaging toolbox"
Oct 30 Milan Mrksich (Northwestern University)
"Combining Arrays and Mass Spectrometry for High Throughput Discovery in Biology"
Nov 13 Joel Collier (University of Chicago)
"Supramolecular Peptide Immunomodulators"
Nov 20 Samie Jaffrey (Cornell University)
"Imaging RNA and RNA biology using RNA mimics of green fluorescent protein"
Dec 4 Amy Rosenzweig (Northwestern University)
"Copper, natural products, and biological methane oxidation"
Spring 2014
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Mar 27 Luke Lavis (HHMI-Janelia Farms)
“Old Dyes, New Tricks: Building Better Fluorophores for Biology”
Apr 10 John Porco (Boston University)
“Chemical Synthesis and Biological Studies of Antitumor Natural Products”
Apr 24 Gregg Fields (Torrey Pines Inst. For Molecular Studies)
“Modulation of Cell Surface Proteolytic Activity”
May 1 Gary Sulikowski (Vanderbilt University)
“Synthesis and Study of Natural Products of Possible Relevance to Human Health”
May 15 Judith Frydman (Stanford University)
“Chaperone control of cellular proteostasis in health and disease”
May 29 Hening Lin (Cornell University)
“Sirtuins and novel protein posttranslational modifications”
June 5 Ron Schnaar (Johns Hopkins University)
“Glycan Recognition in the Control of Inflammation”
Fall 2013
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Oct 24 Magid Abou-Gharbia (Temple University)
“Discovery of innovative therapeutics: Today’s realities and tomorrow’s vision”
Nov 7 John MacMillan (UT Southwestern Medical Center)
“Integration of microbial natural products with high-content screening for cancer drug discovery”
Nov 14 Sam Gellman (University of Wisconsin)
“Mimicry of Protein Surfaces with Alpha/Beta-Peptide Foldamers”
Nov 21 David Fushman (University of Maryland)
“Deciphering the “Ubiquitin Code”: Synthesis and Structure-Function Analysis of Non-Canonical Polyubiquitin Chains”
Dec 5 Tom Kodadek (The Scripps Research Institute - Florida)
“Chemical Tools to Monitor and Manipulate the Proteome”
Dec 12 Anna Mapp (University of Michigan)
“Small Molecule Transcriptional Modulators”
Dec 19 Ryan Looper (University of Utah)
“New methods to access biomedically interesting guanidinium ion scaffolds”
Spring 2013
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Jan 31 Justin DuBois (Stanford University)
"Turning Toxins into Tools for the Study of Ion Channels"
Feb 21 Thomas Williamson (Merck, Inc)
"ADEQUATE: NMR Experiments With an Expanding Role in Structure Elucidation"
Apr 4 Angela Koehler (The Broad Institute)
“Small-molecule probe discovery for transcriptional regulators”
May 2 Chris Lima (MSKCC)
“Structural insights to post-translational modification by Ubiquitin and Ubiquitin-like proteins”
May 23 Jeff Aube (University of Kansas)
“Chemical Probes”
May 30 Jon Thorson (University of Kentucky)
"New strategies and tools for natural product diversification and discovery"
Fall 2012
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Aug 23 Julia Kornfield (Cal Tech)
"Crosslinking of Ocular Tissues"
Sep 20 Ron Koder (City College NY)
"Protein Design Approaches to Cancer Therapies"
Oct 4 Bill Gerwick (UCSD - SIO)
"The Fabulous Natural Products of Marine Cyanobacteria: Structures, Biological Activities, Biosynthetic Pathways"
Nov 8 Derek Tan (MSKCC)
"Diversity and Design: New Chemical Probes for Biology and Medicine"
Dec 13 David Spiegel (Yale University)
“Using Small Molecules to Engineer and Explore Human Immunity”
Spring 2012
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am, unless otherwise noted.
Mar 1 John Toscano (Johns Hopkins University)
"Nitroxyl (HNO): Nitric Oxide's Neglected Sibling"
Mar 12* Jim Wells (UCSF)
"Challenging Targets: Reaching for High Hanging Fruit in Drug Discovery"
*Please note: This seminar is on MONDAY
Apr 5 Phil Dawson (TSRI)
"Chemical Ligation: From Post-Translationally Modified Proteins to Nanoparticle Engineering"
Apr 19 Paul Hanson (University of Kansas)
"Phosphate-Tether Mediated Methods to Bioactive Natural Products and Analogs"
May 3 David Lawrence (UNC at Chapel Hill)
"Cells Are Poor Cuvette Models: Challenges and Prospects of Molecular Probes for Intracellular Biochemistry"
May 24 Peter Wipf (University of Pittsburgh)
"In Search of the Silver Bullet- Redefining the Academic Drug Discovery Trajectory"
Fall 2011
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am, unless otherwise noted.
Sep 15 Ted Molinski (UCSD)
"Marine Natural Products. Scope, Synthesis-Aided Discovery, and New Approaches"
Oct 6 Ben Shen (Scripps Florida)
"Natural Products Drug Discovery: Challenges and Opportunities"
Oct 13 Hai-Quan Mao (Johns Hopkins University)
"Controlled Condensation of DNA and Self-Assembled Polymer/DNA Micelles for Liver-Targeted Gene Delivery"
Nov 3 Carlito Lebrilla (UC - Davis)
"Quantitative Measurements of Protein Glycosylation in Diseases and Health"
Nov 10 Cheryl Arrowsmith (University of Toronto)
"Structural and Chemical Biology of Readers and Writers of the Histone Code"
Nov 17 Matt Bogyo (Stanford University)
"Probing Protease Function Using Small Molecules: Applications from Cancer to Malaria"
Dec 1* Kylie Walters (University of Minnesota)
"Targeting Proteins for Destruction"
*Please note: This seminar will be at 11am instead of 10am.
Spring 2011
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Jan 20 Jiyong Hong (Duke University)
"Natural Product Synthesis at the Interface of Chemistry and Biology"
Feb 3 Chris Ireland (University of Utah)
"Antitumor Agents from Marine Organisms"
Feb 24 Matt Francis (University of California, Berkeley)
"New Chemical Methods for Site Selective Protein Modification"
Mar 24 Dan Kahne (Harvard University)
"How does a cell make more of itself"
Apr 14 Brad Moore (University of California, San Diego/Scripps Institution of Oceanography)
"Genomics-inspired Discovery and Bioengineering of Natural Product Drugs"
May 5 Darrell Irvine (Massachusetts Institute of Technology)
"New materials and new methods for cancer immunotherapy and vaccine delivery"
May 19 Bruce Yu (University of Maryland)
"Developing Imaging Agents for 19F MRI"
Fall 2010
All seminars are given at NCI-Frederick in Bldg 376, Conference Room 121 on Thursdays at 10:00am.
Aug 19 Pieter Dorrestein (University of California, San Diego)
"Translating Adaptive Metabolism with Imaging Mass Spectrometry"
Sept 9 Peter Andreana (Wayne State University)
"Targeting Cellular Immunity with Entirely Carbohydrate-based Constructs"
Sept 16 David Corey (University of Texas Southwest Medical Center)
"Controlling Gene Expression with Synthetic Nucleic Acids"
Oct 7 Scott Miller (Yale University)
"Diverse Peptide-Based Catalysis for Diversification of Biologically Interesting Scaffolds"
Oct 21 Don Engleman (Yale University)
"pH-Dependent Transmembrane Peptide Insertion: Mechanism and Uses in Drug Delivery and Tumor Imaging"
Nov 18 Henry Kopecek (University of Utah)
"Smart Biomaterials and Drug Delivery Systems"