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Alejandro A. Schäffer, Ph.D.

Alejandro A. Schäffer, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Alejandro Schäffer is a computational biologist working on cancer genomics, biological sequence analysis, and medical genetics studies. He specializes in the analysis of sequence data and genetic marker data. Dr. Schäffer joined the Cancer Data Science Laboratory in October 2018.

Areas of Expertise

Biological Sequence Analysis
Algorithms
Genetic Linkage Analysis
Cancer Genomics
Tumor Phylogenetics
Bioinformatics

Publications

Selected Key Publications

Faster Sequential Genetic Linkage Computations

Cottingham RW Jr, Idury RM, Schäffer AA.
American Journal of Human Genetics. 53: 252-263, 1993. [ Journal Article ]

Gapped BLAST and PSI-BLAST: A New Generation of Protein Database Search Programs

Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ.
Nucleic Acids Research. 25: 3389-3402, 1997. [ Journal Article ]

Inferring Tree Models for Oncogenesis from Comparative Genome Hybridization Data

Desper R, Jiang F, Kallioniemi O-P, Moch H, Papadimitriou CH, Schäffer AA.
Journal of Computational Biology. 6: 37-51, 1999. [ Journal Article ]

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schäffer AA, Noyan F, Perro M, Diestelhorst J, Allroth A, Murugan D, Hätscher N, Pfeifer D, Sykora KW, Sauer M, Kreipe H, Lacher M, Nustede R, Woellner C, Baumann U, Salzer U, Koletzko S, Shah N, Segal AW, Sauerbrey A, Buderus S, Snapper SB, Grimbacher B, Klein C.
New England Journal of Medicine. 361: 2033-2045, 2009. [ Journal Article ]

Algorithms to Model Single Gene, Single Chromosome, and Whole Genome Copy Number Changes Jointly in Tumor Phylogenetics

Chowdhury SA, Shackney SE, Heselmeyer-Haddad K, Ried T, Schäffer AA, Schwartz R.
PLoS Computational Biology. 10: e1003740, 2014. [ Journal Article ]