Anuradha S. Budhu, Ph.D.
Anuradha S. Budhu, Ph.D.
Staff Scientist

Dr. Budhu's research focuses on genome-scale analyses of human liver cancer. Her work on gene, microRNA and metabolite profiling, has led to the identification of important signaling molecules that underlie liver cancer biology, with applications to the clinical management of liver cancer.

Dr. Budhu helps to lead a basic/translational research program, emphasizing the discovery of diagnostic, prognostic and predictive biomarkers of liver cancer. These functional genomics investigations utilize bioinformatics and molecular biology, in concert with national/international epidemiological cohorts and clinical studies.

Areas of Expertise
1) functional cancer genomics, 2) hepatocellular carcinoma, 3) systems biology, 4) epidemiology, 5) metastasis, 6) molecular biology

Contact Info

Anuradha S. Budhu, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 37, Room 3050A
Bethesda, MD 20892
301-496-5887
budhua@mail.nih.gov

Dr. Budhu's research interests include studies of human liver cancer, specifically addressing the elucidation of molecular mechanisms involved in hepatocarcinogenesis, including metastasis. These avenues are explored through global molecular and genetic profiling as well as functional experimentation with an emphasis on clinical translation.

Scientific Focus Areas:
Cancer Biology, Cell Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Systems Biology

View Dr. Budhu's Full PubMed Summary.

Selected Key Publications
  1. Budhu A, Roessler S, Zhao X, Yu Z, Forgues M, Ji J, Karoly E, Qin LX, Ye QH, Jia HL, Fan J, Sun HC, Tang ZY, Wang XW.
    Gastroenterology. 144: 1066-1075.e1, 2013. [ Journal Article ]
  2. Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW.
    N Engl J Med. 361: 1437-47, 2009. [ Journal Article ]
  3. Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A, Zanetti KA, Ye QH, Qin LX, Croce CM, Tang ZY, Wang XW.
    Hepatology. 47: 897-907, 2008. [ Journal Article ]
  4. Budhu A, Forgues M, Ye QH, Jia HL, He P, Zanetti KA, Kammula US, Chen Y, Qin LX, Tang ZY, Wang XW.
    Cancer Cell. 10: 99-111, 2006. [ Journal Article ]
  5. Wang W, Budhu A, Forgues M, Wang XW.
    Nat Cell Biol. 7: 823-30, 2005. [ Journal Article ]

Dr. Anuradha Budhu began her scientific career as a student researcher in the Undergraduate Biology Research Program (UBRP) at the University of Arizona, studying gene expression patterns in the larval brain of Drosophila Melanogaster. These studies were continued at The University of Adelaide in Australia through the UBRP Biomedical Research Abroad Vistas Open (Bravo!) Program funded by a Howard Hughes fellowship. After completion of her bachelor's honors degree (Cum Laude)in Biochemistry/Molecular and Cellular Biology from the University of Arizona, Dr. Budhu joined the graduate program in Biochemistry at Cornell University, where she earned her Ph.D. studying the roles of retinoids in mammary carcinoma. In 2002, she joined the Laboratory of Human Carcinogenesis at NCI as a Cancer Research Training Award (CRTA) postdoctoral fellow in the Liver Carcinogenesis Section. She was promoted to Staff Scientist in 2007. Dr. Budhu has authored over 35 peer-reviewed articles and 6 book chapters. Dr. Budhu is an active member of the Staff Scientist and Staff Clinician (SSSC) community at CCR, serving as Co-Chair of the SSSC Communications Committee and Editor-in-Chief of the SSSC newsletter (The Dossier). She is the recipient of several awards, including the CCR's Outstanding Postdoctoral Award and the NCI Director's Innovation Award.

Research

Dr. Budhu's research interests include studies of human liver cancer, specifically addressing the elucidation of molecular mechanisms involved in hepatocarcinogenesis, including metastasis. These avenues are explored through global molecular and genetic profiling as well as functional experimentation with an emphasis on clinical translation.

Scientific Focus Areas:
Cancer Biology, Cell Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Systems Biology

Publications

View Dr. Budhu's Full PubMed Summary.

Selected Key Publications
  1. Budhu A, Roessler S, Zhao X, Yu Z, Forgues M, Ji J, Karoly E, Qin LX, Ye QH, Jia HL, Fan J, Sun HC, Tang ZY, Wang XW.
    Gastroenterology. 144: 1066-1075.e1, 2013. [ Journal Article ]
  2. Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW.
    N Engl J Med. 361: 1437-47, 2009. [ Journal Article ]
  3. Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A, Zanetti KA, Ye QH, Qin LX, Croce CM, Tang ZY, Wang XW.
    Hepatology. 47: 897-907, 2008. [ Journal Article ]
  4. Budhu A, Forgues M, Ye QH, Jia HL, He P, Zanetti KA, Kammula US, Chen Y, Qin LX, Tang ZY, Wang XW.
    Cancer Cell. 10: 99-111, 2006. [ Journal Article ]
  5. Wang W, Budhu A, Forgues M, Wang XW.
    Nat Cell Biol. 7: 823-30, 2005. [ Journal Article ]

Biography

Dr. Anuradha Budhu began her scientific career as a student researcher in the Undergraduate Biology Research Program (UBRP) at the University of Arizona, studying gene expression patterns in the larval brain of Drosophila Melanogaster. These studies were continued at The University of Adelaide in Australia through the UBRP Biomedical Research Abroad Vistas Open (Bravo!) Program funded by a Howard Hughes fellowship. After completion of her bachelor's honors degree (Cum Laude)in Biochemistry/Molecular and Cellular Biology from the University of Arizona, Dr. Budhu joined the graduate program in Biochemistry at Cornell University, where she earned her Ph.D. studying the roles of retinoids in mammary carcinoma. In 2002, she joined the Laboratory of Human Carcinogenesis at NCI as a Cancer Research Training Award (CRTA) postdoctoral fellow in the Liver Carcinogenesis Section. She was promoted to Staff Scientist in 2007. Dr. Budhu has authored over 35 peer-reviewed articles and 6 book chapters. Dr. Budhu is an active member of the Staff Scientist and Staff Clinician (SSSC) community at CCR, serving as Co-Chair of the SSSC Communications Committee and Editor-in-Chief of the SSSC newsletter (The Dossier). She is the recipient of several awards, including the CCR's Outstanding Postdoctoral Award and the NCI Director's Innovation Award.