Jennifer Clare Jones, M.D., Ph.D.

Jennifer Clare Jones, M.D., Ph.D.
Assistant Research Physician

Dr. Jones (McIntire) positionally cloned the TIM gene family and demonstrated the genetic association between TIMs and immune response profiles (McIntire et al., Nature Immunology 2001, and Nature 2003). As a radiation oncologist, her current research is focused on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.

Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Dr. Jones is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a flow cytometry core facility, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.

Areas of Expertise
1) tumor immunology 2) radiobiology 3) (nano) flow cytometry 4) nanoscale particle analysis (particularly exosomes, microparticles, and other extracellular vesicles) 5) immune receptor immunogenetics and evolution 6) vaccine and immunotherapy development

Contact Info

Jennifer Clare Jones, M.D., Ph.D.
Center for Cancer Research
National Cancer Institute
Building 41, Room D702B
Bethesda, MD 20892-5062
Ph: 301-496-5457
jennifer.jones2@nih.gov

My current research focuses on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.

Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Our laboratory is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a flow cytometry core facility, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.

Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Clinical Research, Genetics and Genomics, Immunology
  1. Morales-Kastresana A, Telford B, Musich TA, McKinnon K, Clayborne C, Braig Z, Rosner A, Demberg T, Watson DC, Karpova TS, Freeman GJ, DeKruyff RH, Pavlakis GN, Terabe M, Robert-Guroff M, Berzofsky JA, and Jones JC.
    Sci Rep. 7(1): 1878, 2017. [ Journal Article ]
  2. Nolan JP, Jones JC.
    Platelets. 28(3): 256-262, 2017. [ Journal Article ]
  3. Morales-Kastresana A, Jones JC.
    Methods Mol Biol. 1545: 215-225, 2017. [ Journal Article ]
  4. Mateescu B, Kowal EJ, van Balkom BW, Bartel S, Bhattacharyya SN, Buzás EI, Buck AH, de Candia P, Chow FW, Das S, Driedonks TA, Fernández-Messina L, Haderk F, Hill AF, Jones JC, Van Keuren-Jensen KR, Lai CP, Lässer C, Liegro ID, Lunavat TR, Lorenowicz MJ, Maas SL, Mäger I, Mittelbrunn M, Momma S, Mukherjee K, Nawaz M, Pegtel DM, Pfaffl MW, Schiffelers RM, Tahara H, Théry C, Tosar JP, Wauben MH, Witwer KW, and Nolte-'t Hoen EN.
    J Extracell Vesicles. 6(1): 1286095, 2017. [ Journal Article ]
  5. Musich T, Jones JC, Keele BF, Jenkins LM, Demberg T, Uldrick TS, Yarchoan R, and Robert-Guroff M.
    JCI Insight. 2(4): e90626, 2017. [ Journal Article ]

Dr. Jones received her M.D. and Ph.D. from Stanford University. She is a board-certified radiation oncologist specialized training in radiosurgery and graduate and postdoctoral training in both cancer biology and general immunology.

Name Position
Aizea Morales-Kastresana Ph.D. Postdoctoral Fellow (Visiting)
Joshua A. Welsh Ph.D. Postdoctoral Fellow (Visiting)

links to come