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R. Andrew  Byrd, Ph.D.

R. Andrew Byrd, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
NIH Scientist Emeritus
Center for Structural Biology

RESEARCH SUMMARY

Dr. Byrd was prominent in developing NMR-based structural biology for the study of proteins, nucleic acids, polysaccharides, and protein complexes. His research focused on deciphering allosteric mechanisms in the ubiquitination pathway regulating protein degradation/homeostatis and the roles of ADP ribosylation factors and GTPase activating proteins in regulating membrane trafficking. Dr. Byrd served as Chief of the Structural Biophysics Laboratory from 1999-2017 and continued as Head of the Macromolecular NMR Section until 2024. His group contributed to the development and impact of structural biology within the CCR and conducts an active, multidisciplinary research effort utilizing biophysics and NMR spectroscopy to provide mechanistic understanding of complex biological processes.

Areas of Expertise

Structural Biology in Cancer
NMR
Biophysics
Ubiquitination

Publications

Selected Key Publications

Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1

Zhang Y, Soubias O, Pant S, Heinrich F, Vogel A, Li J, Yifei Li, Clifton LA, Daum S, Bacia K, Huster D, Randazzo PA, Lösche M, Tajkhorshid E, Byrd RA.
Nature Communications. 14:7570: 2023.
Full-Text Article(link is external)
[ Journal Article ]

Membrane surface recognition by the ASAP1 PH domain and consequences for interactions with the small GTPase Arf1

Soubias, O., Pant, S., Heinrich, F., Zhang, Y., Roy, N.S., Li, J., Jian, X., Yohe, M.E., Randazzo, P.A., Losche, M., Tajkhorshid, E., Byrd, R.A.
Science Advances. Vol 6, Issue 40: 2020.
Full-Text Article(link is external)
[ Journal Article ]

Optimization of Sortase A Ligation for Flexible Engineering of Complex Protein Systems

Li J, Zhang Y, Soubias O, Khago D, Chao FA, Li Y, Shaw K, Byrd RA
J. Biol Chem. 295(9): 2664-75, 2020. [ Journal Article ]

Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine

Das R, Liang YH, Mariano J, Li J, Huang T, King A, Tarasov SG, Weissman AM, Ji X, Byrd RA.
EMBO J. 32: 2504-16, 2013. [ Journal Article ]

Alumni

Fa-An Chao
Fa-An Chao
(2014-2020)
Postdoctoral Fellow
Guneet Janda
Guneet Janda
2018-2019
Postbac Fellow
Yifei Li
Yifei Li
(2014-2019)
Postdoctoral Fellow
Cameron McGlone, B.S.
Cameron McGlone, B.S.
(2015-2017)
Postbaccalaureate Fellow
Michelle Gill, Ph.D.
Michelle Gill, Ph.D.
(2014-2016)
Research Fellow
View All