Murali Palangat Ph.D.

National Cancer Institute Center for Cancer Research
    Murali Palangat Ph.D.
  
Research Biologist
Laboratory of Receptor Biology and Gene Expression
Research Biologist

Team Member of:
Daniel R. Larson, Ph.D.
My two primary research areas of interest are (i) understanding the structure-function of splicing factor U2AF-RNA interactions during translation and how its regulation controls gene expression and, (ii) how the cancer associated splicing factor mutations alter RNA fate leading to control of gene expression and their role in cancer biology.
Areas of Expertise1. Biochemistry and Molecular Biology. 2. Single molecule transcription. 3. In vivo live cell imaging.
        Contact Info          
Murali Palangat Ph.D.

Center for Cancer Research

National Cancer Institute

Building 41, Room B303

Bethesda, MD 20892

Ph: 240-760-6692

Fax: 240-541-4450

murali.palangat@nih.gov

Publications
Selected Publications
            The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation.  
Palangat M, Anastasakis DG, Fei DL, Lindblad KE, Bradley R, Hourigan CS, Hafner M, Larson DR
                  Genes and Development.          DOI: 10.1101/gad.319590.118:                                        2019.          [ Journal Article ]  
         Single-Gene Dual-Color Reporter Cell Line to Analyze RNA Synthesis in vivo.  
Palangat M and Larson DR
                  Methods “RNA Structure Determination”.                                                  2016.          [ Journal Article ]  
        Kinetic competition during the transcription cycle results in stochastic RNA processing.  
Coulon A, Ferguson ML, de Turris V, Palangat M, Chow CC, Larson DR
                  Elife.                                                  2014.          [ Journal Article ]  
        Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.  
Windgassen TA, Mooney RA, Nayak D, Palangat M, Zhang J, Landick R
                  Nucl. Acids Res.          42:                              12707-12721,          2014.          [ Journal Article ]  
        Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II.  
Larson M, Kaplan CD, Zhou J, Palangat M, Kornberg R, Landick R and Block M
                  Proc. Natl. Acad. Sci. USA.          109:                              6555-6560,          2012.          [ Journal Article ]