Murali Palangat Ph.D.

Murali Palangat Ph.D.
Research Biologist
Laboratory of Receptor Biology and Gene Expression
Research Biologist

Team Member of:

Daniel R. Larson, Ph.D.

My two primary research areas of interest are (i) understanding the structure-function role of protein nucleic acids interaction during transcript elongation by human RNA polymerase II and how its regulation controls gene expression. (ii) Understanding how splicing factor mutations alter RNA fate leading to control of gene expression, and their role in cancer biology.

Areas of Expertise
1. Biochemistry and Molecular Biology. 2. Single molecule transcription. 3. In vivo live cell imaging.

Contact Info

Murali Palangat Ph.D.
Center for Cancer Research
National Cancer Institute
Building 41, Room B303
Bethesda, MD 20892
Ph: 240-760-6692
Fax: 240-541-4450
palangat.murali@nih.gov
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Selected Publications

  1. Single-Gene Dual-Color Reporter Cell Line to Analyze RNA Synthesis in vivo.
    Palangat M and Larson DR
    Methods “RNA Structure Determination”. 2016. [ Journal Article ]
  2. Kinetic competition during the transcription cycle results in stochastic RNA processing.
    Coulon A, Ferguson ML, de Turris V, Palangat M, Chow CC, Larson DR
    Elife. 2014. [ Journal Article ]
  3. Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.
    Windgassen TA, Mooney RA, Nayak D, Palangat M, Zhang J, Landick R
    Nucl. Acids Res. 42: 12707-12721, 2014. [ Journal Article ]
  4. Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II.
    Larson M, Kaplan CD, Zhou J, Palangat M, Kornberg R, Landick R and Block M
    Proc. Natl. Acad. Sci. USA. 109: 6555-6560, 2012. [ Journal Article ]
  5. Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II.
    Palangat M, Larson M, Hu X, Gnatt A, Block M and Landick R
    Transcription. 3: 146-153, 2012. [ Journal Article ]