Murali Palangat Ph.D.
My two primary research areas of interest are (i) understanding the structure-function of splicing factor U2AF-RNA interactions during translation and how its regulation controls gene expression and, (ii) how the cancer associated splicing factor mutations alter RNA fate leading to control of gene expression and their role in cancer biology.
1. Biochemistry and Molecular Biology. 2. Single molecule transcription. 3. In vivo live cell imaging.
The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation.Genes and Development. DOI: 10.1101/gad.319590.118: 2019. [ Journal Article ]
- Methods “RNA Structure Determination”. 2016. [ Journal Article ]
- Elife. 2014. [ Journal Article ]
Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.Nucl. Acids Res. 42: 12707-12721, 2014. [ Journal Article ]
Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II.Proc. Natl. Acad. Sci. USA. 109: 6555-6560, 2012. [ Journal Article ]