Murali Palangat Ph.D.

Murali Palangat Ph.D.
Research Biologist
Laboratory of Receptor Biology and Gene Expression
Research Biologist

Team Member of:

Daniel R. Larson, Ph.D.

My two primary research areas of interest are (i) understanding the structure-function of splicing factor U2AF-RNA interactions during translation and how its regulation controls gene expression and, (ii) how the cancer associated splicing factor mutations alter RNA fate leading to control of gene expression and their role in cancer biology.

Areas of Expertise

1. Biochemistry and Molecular Biology. 2. Single molecule transcription. 3. In vivo live cell imaging.

Contact Info

Murali Palangat Ph.D.
Center for Cancer Research
National Cancer Institute
Building 41, Room B303
Bethesda, MD 20892
Ph: 240-760-6692
Fax: 240-541-4450
murali.palangat@nih.gov
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Selected Publications

  1. The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation.
    Palangat M, Anastasakis DG, Fei DL, Lindblad KE, Bradley R, Hourigan CS, Hafner M, Larson DR
    Genes and Development. DOI: 10.1101/gad.319590.118: 2019. [ Journal Article ]
  2. Single-Gene Dual-Color Reporter Cell Line to Analyze RNA Synthesis in vivo.
    Palangat M and Larson DR
    Methods “RNA Structure Determination”. 2016. [ Journal Article ]
  3. Kinetic competition during the transcription cycle results in stochastic RNA processing.
    Coulon A, Ferguson ML, de Turris V, Palangat M, Chow CC, Larson DR
    Elife. 2014. [ Journal Article ]
  4. Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.
    Windgassen TA, Mooney RA, Nayak D, Palangat M, Zhang J, Landick R
    Nucl. Acids Res. 42: 12707-12721, 2014. [ Journal Article ]
  5. Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II.
    Larson M, Kaplan CD, Zhou J, Palangat M, Kornberg R, Landick R and Block M
    Proc. Natl. Acad. Sci. USA. 109: 6555-6560, 2012. [ Journal Article ]