Murali Palangat Ph.D.
My two primary research areas of interest are (i) understanding the structure-function role of protein nucleic acids interaction during transcript elongation by human RNA polymerase II and how its regulation controls gene expression. (ii) Understanding how splicing factor mutations alter RNA fate leading to control of gene expression, and their role in cancer biology.
- Methods “RNA Structure Determination”. 2016. [ Journal Article ]
- Elife. 2014. [ Journal Article ]
Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.Nucl. Acids Res. 42: 12707-12721, 2014. [ Journal Article ]
Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II.Proc. Natl. Acad. Sci. USA. 109: 6555-6560, 2012. [ Journal Article ]
Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II.Transcription. 3: 146-153, 2012. [ Journal Article ]