Fedor Kouzine, Ph.D.

Fedor Kouzine, Ph.D.
Staff Scientist

Dr. Kouzine focuses on the understanding of how mechanical forces generated by genetic processes modify DNA and chromatin structure to regulate genes in health and disease. His work showed that in living cells torque generated during transcription modifies DNA structure dynamically at particular supercoil-sensitive spots in the genome. These unusual DNA structures then bind by specialized factors to feedback regulate gene expression. This work has important implications for the understanding and treatment of human diseases such as cancer. 

Areas of Expertise

1) epigenetics and nuclear architecture, 2) DNA topology and topoisomerases,
3) gene expression

Contact Info

Fedor Kouzine, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 2N105
Bethesda, Maryland 20892
Ph: 301-594-0442

Dr. Kouzine is a physicist who tends to favor interdisciplinary approaches, whether it is to understand dynamics of genome 3D organization or gene transcription. Whatever the focus is on, this is all about how macro-molecules behavior and mechanics regulate normal genetic processes or contribute to diseases. Dr. Kouzine's research interests currently focus on the coupling and interdependence of DNA topology, DNA structure, chromatin architecture and transcription from a genome-wide perspective.

NIH Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Chromosome Biology, Molecular Biology and Biochemistry

Selected Key Publications

  1. Kouzine F, Wojtowicz D, Baranello L, Yamane A, Nelson S, Resch W, Kieffer-Kwon KR, Benham CJ, Casellas R, Przytycka TM, and Levens D.
    Cell Systems. 4(3): 344-356, 2017. [ Journal Article ]
  2. Kouzine F, Wojtowicz D, Yamane A, Resch W, Kieffer-Kwon KR, Bandle R, Nelson S, Nakahashi H, Awasthi P, Feigenbaum L, Menoni H, Hoeijmakers J, Vermeulen W, Ge H, Przytycka TM, Levens D, and Casellas R.
    Cell. 153(5): 988-99, 2013. [ Journal Article ]
  3. Kouzine F, Gupta A, Baranello L, Wojtowicz D, Ben-Aissa K, Liu J, Przytycka TM, and Levens D.
    Nat Struct Mol Biol. 20(3): 396-403, 2013. [ Journal Article ]

Dr. Kouzine received his Ph.D. from the Institute of Cytology and Genetics, Russian Academy of Science. In 2001, he joined the team of the Gene Regulation Section of the Laboratory of Pathology as a Postdoctoral Visiting Fellow.  In 2009 he became a Staff Scientist. Dr. Kouzine has co-authored over 20 scientific publications.