Fedor Kouzine, Ph.D.
Dr. Kouzine focuses on the understanding of how mechanical forces generated by genetic processes modify DNA and chromatin structure to regulate genes in health and disease. His work showed that in living cells torque generated during transcription modifies DNA structure dynamically at particular supercoil-sensitive spots in the genome. These unusual DNA structures then bind by specialized factors to feedback regulate gene expression. This work has important implications for the understanding and treatment of human diseases such as cancer.
1) epigenetics and nuclear architecture
2) DNA topology and topoisomerases
3) gene expression
Dr. Kouzine is a physicist who tends to favor interdisciplinary approaches, whether it is to understand dynamics of genome 3D organization or gene transcription. Whatever the focus is on, this is all about how macro-molecules behavior and mechanics regulate normal genetic processes or contribute to diseases. Dr. Kouzine's research interests currently focus on the coupling and interdependence of DNA topology, DNA structure, chromatin architecture and transcription from a genome-wide perspective.
Selected Key Publications
Permanganate/S1 Nuclease Footprinting Reveals Non-B DNA Structures with Regulatory Potential across a Mammalian Genome.Cell Systems. 4(3): 344-356, 2017. [ Journal Article ]
- Cell. 153(5): 988-99, 2013. [ Journal Article ]
- Nat Struct Mol Biol. 20(3): 396-403, 2013. [ Journal Article ]
Dr. Kouzine received his Ph.D. from the Institute of Cytology and Genetics, Russian Academy of Science. In 2001, he joined the team of the Gene Regulation Section of the Laboratory of Pathology as a Postdoctoral Visiting Fellow. In 2009 he became a Staff Scientist. Dr. Kouzine has co-authored over 20 scientific publications.