Jung-Eun Park, Ph.D.

Jung-Eun Park, Ph.D.
Staff Scientist
Laboratory of Metabolism

Team Member of:

Kyung S. Lee, Ph.D.

Dr. Park's primary research interest lies in understanding the physiological functions of two functionally distinct mammalian polo-like kinases, Plk1 and Plk4, which appear to play key roles in mitotic progression and centriole duplication, respectively. Dr. Park is also interested in developing anti-Plk1 therapeutic agents by exploiting both potential leads from our own research and from the unique resources that NCI provides to the intramural community.

Areas of Expertise

kinases

Contact Info

Jung-Eun Park, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 37, Room 3118
Bethesda, MD 20892-4254
Ph: 240-760-7281
parkju@mail.nih.gov
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Dr. Park's primary research interest lies in understanding the physiological functions of two functionally distinct mammalian polo-like kinases, Plk1 and Plk4, which appear to play key roles in mitotic progression and centriole duplication, respectively. Dr. Park is also interested in developing anti-Plk1 therapeutic agents by exploiting both potential leads from our own research and from the unique resources that NCI provides to the intramural community.

Selected Publications

  1. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
    Liu F, Park J, Qian W, Lim D, Graber M, Berg T, Yaffe MB, Lee KS, Burke TR.
    Nat. Chem. Biol.. 7: 595-601, 2011. [ Journal Article ]
  2. Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay.
    Park JE, Li L, Park J, Knecht R, Strebhardt K, Yuspa SH, Lee KS.
    Proc. Natl. Acad. Sci. U.S.A.. 106: 1725-30, 2009. [ Journal Article ]
  3. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
    Yun S, Moulaei T, Lim D, Bang JK, Park J, Shenoy SR, Liu F, Kang YH, Liao C, Soung N, Lee S, Yoon D, Lim Y, Lee D, Otaka A, Appella E, McMahon JB, Nicklaus MC, Burke TR, Yaffe MB, Wlodawer A, Lee KS.
    Nat. Struct. Mol. Biol.. 16: 876-82, 2009. [ Journal Article ]
  4. Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.
    Kim TS, Park JE, Shukla A, Choi S, Murugan RN, Lee JH, Ahn M, Rhee K, Bang JK, Kim BY, Loncarek J, Erikson RL, Lee KS.
    Proc. Natl. Acad. Sci. U.S.A.. 110: E4849-57, 2013. [ Journal Article ]
  5. Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate.
    Park JE, Erikson RL, Lee KS.
    Proc. Natl. Acad. Sci. U.S.A.. 108: 8200-5, 2011. [ Journal Article ]

Dr. Jung-Eun Park joined the NIH in 2002 as an Office of International Affairs' predoctoral fellow and received her Ph.D. in 2004 from the Department of Biology at the Dong-A University, South Korea. She then obtained her postdoctoral research training at the NCI and became a staff scientist in the Laboratory of Metabolism, CCR, in 2010.