Jung-Eun Park, Ph.D.

Jung-Eun Park, Ph.D.
Staff Scientist
Laboratory of Metabolism

Team Member of:

Kyung S. Lee, Ph.D.

Dr. Park's primary research interest lies in understanding the physiological functions of two functionally distinct mammalian polo-like kinases, Plk1 and Plk4, which appear to play key roles in mitotic progression and centriole duplication, respectively. Dr. Park is also interested in developing anti-Plk1 therapeutic agents by exploiting both potential leads from our own research and from the unique resources that NCI provides to the intramural community.

Areas of Expertise

kinases

Contact Info

Jung-Eun Park, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 37, Room 3118
Bethesda, MD 20892-4254
Ph: 240-760-7281
parkju@mail.nih.gov

Dr. Park's primary research interest lies in understanding the physiological functions of two functionally distinct mammalian polo-like kinases, Plk1 and Plk4, which appear to play key roles in mitotic progression and centriole duplication, respectively. Dr. Park is also interested in developing anti-Plk1 therapeutic agents by exploiting both potential leads from our own research and from the unique resources that NCI provides to the intramural community.

Selected Publications

  1. Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis.
    Park JE, Zhang L, Bang JK, Andresson T, DiMaio F, Lee KS.
    Nat Commun. 10(1): 4959, 2019. [ Journal Article ]
  2. Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.
    Park SY*, Park JE*, Kim TS*, Kim JH*, Kwak MJ*, Ku B*, Tian L, Murugan RN, Ahn M, Komiya S, Hojo H, Kim NH, Kim BY, Bang JK, Erikson RL, Lee KW, Kim SJ, Oh BH, Yang W, Lee KS.
    Nat. Struct. Mol. 21(8): 696-703, 2014. [ Journal Article ]
  3. Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate.
    Park JE, Erikson RL, Lee KS.
    Proc. Natl. Acad. Sci. U.S.A. 108: 8200-5, 2011. [ Journal Article ]
  4. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
    Liu F*, Park JE*, Qian W, Lim D, Graber M, Berg T, Yaffe MB, Lee KS*, Burke TR*.
    Nat. Chem. Biol. 7: 595-601, 2011. [ Journal Article ]
  5. Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay.
    Park JE, Li L, Park J, Knecht R, Strebhardt K, Yuspa SH, Lee KS.
    Proc. Natl. Acad. Sci. U.S.A. 106: 1725-30, 2009. [ Journal Article ]

Dr. Jung-Eun Park joined the NIH in 2002 as an Office of International Affairs' predoctoral fellow and received her Ph.D. in 2004 from the Department of Biology at the Dong-A University, South Korea. She then obtained her postdoctoral research training at the NCI and became a staff scientist in the Laboratory of Metabolism, CCR, in 2010.

Dr. Park is the recipient of several NCI Federal Technology Transfer Awards for her inventions and patents related to Plk1. She serves as an editorial board member for Cells.