Rosalba Salcedo, Ph.D.

Rosalba Salcedo, Ph.D.
Staff Scientist
Laboratory of Integrative Cancer Immunology

Team Member of:

Giorgio Trinchieri, M.D.

Dr. Salcedo's research focuses on the role of chronic inflammation in the promotion of cancer. She is using several genetic and chemical models of skin and colon carcinogenesis to elucidate the protective and detrimental effects of innate immune responses in the induction and subsequent outgrowth of tumors.

Areas of Expertise

1) chronic inflammation, 2) genetic and chemical models

Contact Info

Rosalba Salcedo, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 37, Room 4140
Bethesda, MD 20892
Ph: 240-760-772
salcedor@mail.nih.gov

Our research is focused on the role of chronic inflammation in the promotion of cancer. Several genetic and chemical models of skin and colon carcinogenesis are being used to elucidate the protective and detrimental effects of innate immune responses in the induction and subsequent outgrowth of tumors.

Selected Publications

  1. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.
    Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, Dai RM, Kiu H, Cardone M, Naik S, Patri AK, Wang E, Marincola FM, Frank KM, Belkaid Y, Trinchieri G, Goldszmid RS.
    Science. 342: 967-70, 2013. [ Journal Article ]
  2. Laser capture microdissection for protein and NanoString RNA analysis.
    Golubeva Y, Salcedo R, Mueller C, Liotta LA, Espina V.
    Methods Mol Biol. 931: 213-57, 2013. [ Journal Article ]
  3. MyD88 and its divergent toll in carcinogenesis.
    Salcedo R, Cataisson C, Hasan U, Yuspa SH, Trinchieri G.
    Trends Immunol. 34: 379-89, 2013. [ Journal Article ]
  4. Compartmentalized control of skin immunity by resident commensals.
    Naik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W, Deming C, Quinones M, Koo L, Conlan S, Spencer S, Hall JA, Dzutsev A, Kong H, Campbell DJ, Trinchieri G, Segre JA, Belkaid Y.
    Science. 337: 1115-9, 2012. [ Journal Article ]
  5. High-throughput molecular and histopathologic profiling of tumor tissue in a novel transplantable model of murine neuroblastoma: new tools for pediatric drug discovery.
    Stauffer JK, Orentas RJ, Lincoln E, Khan T, Salcedo R, Hixon JA, Back TC, Wei JS, Patidar R, Song Y, Hurd L, Tsokos M, Lai EW, Eisenhofer G, Weiss W, Khan J, Wigginton JM.
    Cancer Invest. 30: 343-63, 2012. [ Journal Article ]

Dr. Salcedo received her doctoral training in immunology at the Karolinska Institute at Stockholm, Sweden, graduating in 1996. In 1997, she joined the Laboratory of Molecular Immunoregulation under Dr. Joost J. Oppenheim and worked on projects regarding the roles of chemokines in angiogenesis and tumorigenesis. In 2002, she began working in the Pediatric Oncology Branch under Dr. Jon M. Wigginton, exploring novel approaches for the treatment of neuroblastoma by utilizing preclinical models. In October 2006, she joined the Cancer and Inflammation Program, under Dr. Giorgio Trinchieri.