Anuradha S. Budhu, Ph.D.
Dr. Budhu's research focuses on genome-scale analyses of human liver cancer. Her work on gene, microRNA and metabolite profiling, has led to the identification of important signaling molecules that underlie liver cancer biology, with applications to the clinical management of liver cancer.
Dr. Budhu helps to lead a basic/translational research program, emphasizing the discovery of diagnostic, prognostic and predictive biomarkers of liver cancer. These functional genomics investigations utilize bioinformatics and molecular biology, in concert with national/international epidemiological cohorts and clinical studies.
1) functional cancer genomics, 2) hepatocellular carcinoma, 3) systems biology, 4) epidemiology, 5) metastasis, 6) molecular biology
Dr. Budhu's research interests include studies of human liver cancer, specifically addressing the elucidation of molecular mechanisms involved in hepatocarcinogenesis, including metastasis. These avenues are explored through global molecular and genetic profiling as well as functional experimentation with an emphasis on clinical translation.
Selected Key Publications
Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.Gastroenterology. 144: 1066-1075.e1, 2013. [ Journal Article ]
- N Engl J Med. 361: 1437-47, 2009. [ Journal Article ]
- Hepatology. 47: 897-907, 2008. [ Journal Article ]
Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment.Cancer Cell. 10: 99-111, 2006. [ Journal Article ]
- Nat Cell Biol. 7: 823-30, 2005. [ Journal Article ]
Dr. Anuradha Budhu began her scientific career as a student researcher in the Undergraduate Biology Research Program (UBRP) at the University of Arizona, studying gene expression patterns in the larval brain of Drosophila Melanogaster. These studies were continued at The University of Adelaide in Australia through the UBRP Biomedical Research Abroad Vistas Open (Bravo!) Program funded by a Howard Hughes fellowship. After completion of her bachelor's honors degree in Biochemistry/Molecular and Cellular Biology from the University of Arizona, Dr. Budhu joined the graduate program in Biochemistry at Cornell University, where she earned her Ph.D. studying the roles of retinoids in mammary carcinoma. In 2002, she joined the Laboratory of Human Carcinogenesis at NCI as a Cancer Research Training Award (CRTA) postdoctoral fellow in the Liver Carcinogenesis Section. She was promoted to Staff Scientist in 2007 and Associate Scientist in 2018. Dr. Budhu has authored over 50 peer-reviewed articles and 6 book chapters. Dr. Budhu is an active member of the Staff Scientist and Staff Clinician (SSSC) community at CCR, having served as Co-Chair of the SSSC Communications Committee and Editor-in-Chief and Founder of the SSSC newsletter (The Dossier). She is the recipient of several awards, including the CCR's Outstanding Postdoctoral Award, the NCI Director's Innovation Award and the NCI Director's Award. Dr. Budhu is currently a Senior Associate Scientist and the Program Manager for the NCI CCR Liver Cancer Program.