Christina H. Stuelten, M.D., Ph.D.
Dr. Stuelten obtained her PhD and her MD at the University of Tuebingen, Germany. After clinical training in surgery and laboratory medicine, Dr. Stuelten joined the Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, as a postdoctoral fellow. She then continued her research on the role of TGF-beta in tumor-stroma interactions and cell differentiation in the Cell and Cancer Biology Branch. In 2011 Dr. Stuelten joined the Laboratory of Cellular and Molecular Biology as a staff scientist where she currently works on the regulation of cell migration and metastasis.
1) TGF-beta signaling, 2) tumor-stromal interactions, 3) tissue repair, 4) breast cancer, 5) cell migration
Dr. Stuelten’s research focuses on TGF-beta signaling and its role in cell migration, tissue repair and tumor disease. Her work has led to the identification of mechanisms that underlie tumor progression and wound-promoted tumor growth.
Lysophosphatidic acid regulates the motility of MCF10CA1a breast cancer cell sheets via two opposing signaling pathways.Cell Signal. Jan 11;45: 1-11, 2018. [ Journal Article ]
- J Clin Cell Immunol.. Oct;7(5): 2016. [ Journal Article ]
- PLoS ONE. Apr 11;8(4): e60919, 2013. [ Journal Article ]
Transient tumor-fibroblast interactions increase tumor cell malignancy by a TGF-beta mediated mechanism in a mouse xenograft model of breast cancer.PLS One.. Mar 23;5(3): e9832., 2010. [ Journal Article ]
- Cancer Res.. Sep 15;68(18): 7278-82, 2008. [ Journal Article ]
Dr. Stuelten obtained her PhD and her MD at the University of Tuebingen, Germany. After residency training in surgery and laboratory medicine, Dr. Stuelten joined the laboratory of Anita Roberts at the National Cancer Institute, Bethesda, as a postdoctoral fellow, to study the role of TGF-beta signaling in breast cancer progression in 2003, and continued her research on the role of TGF-beta and microenvironmental cues on tumor progression in the Cell and Cancer Biology Branch from 2006 on. In 2011 Dr. Stuelten joined NCI’s Laboratory of Cellular and Molecular Biology as a staff scientist where she investigated the effect of microenvironmental cues on breast cancer cell migration using automated image analysis, and currently works on TGF-beta signaling in the context of cell migration, tumor progression and wound healing.
Dr. Stuelten is an active member of the Staff Scientist and Staff Clinician (SSSC) community at CCR, and currently organizes the SSSC Brown Bag Lunch Seminar series. She is the recipient of several awards, including the NCI Director’s Innovation Award.