Yan Lin Yu, Ph.D.
Dr. Yu’s major research interest is the complex molecular and genetic mechanisms in genesis and progression to the metastatic state of cancer, in order to identify candidate molecular targets or signaling pathways for the mechanistic enlightenment, clinical diagnosis and therapeutic utility, as well as preventing cancer. His current studies focus on interaction between tumor cell and microenvironment especially immune system in tumor metastasis, role of PTEN in metastatic suppression pathway and mechanisms of organs specific metastasis.
Dr. Yu's major research interest is focused on understanding molecular mechanisms in progression to the metastatic state in cancer. He has studied mechanisms underlying tumorigenesis in the hepatocellular carcinoma (HCC). Dr. Yu has generating transgenic mice inducibly expressing dominant negative fibroblast growth factor receptor (FGFR) mutants for studying the specific roles of receptor tyrosine kinases in cancer and normal development. He found that constitutive c-Met signaling through a non-autocrine mechanism promotes metastasis in a transgenic transplantation model, and determined that Ezrin and Six1 are critical regulators of metastasis in rhabdomyosarcoma.
Epigenetic Drugs Can Stimulate Metastasis through Enhanced Expression of the Pro-Metastatic Ezrin Gene.PloS one. 5: 2010. [ Journal Article ]
- Am. J. Pathol.. 176: 2088-91, 2010. [ Journal Article ]
Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.J. Clin. Invest.. 119: 3395-407, 2009. [ Journal Article ]
The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis.Cancer Res.. 66: 1982-9, 2006. [ Journal Article ]
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.Nat. Med.. 10: 175-81, 2004. [ Journal Article ]
Dr. Yanlin Yu graduated from Southern Medical University. He received an M.Sc degree in Genetics from Jinan University and a Ph.D. degree in Cell Biology from the Shanghai Institute of Cell Biology (currently named Shanghai Institute of Biochemistry and Cell Biology) in the Chinese Academy of Sciences. Dr. Yu was a faculty member at the Department of Cell Biology and Genetics in Southern Medical University. From 1998 to 2004, Dr. Yu worked at the Laboratory of Molecular Biology in the National Cancer Institute as a visiting fellow and research fellow. He currently works with Dr. Glenn Merlino in Laboratory of Cancer Biology and Genetics as a staff scientist. Dr. Yu won a NCI Director's Intramural Innovation Award in 2006.