Yue Hu, Ph.D.

Yue Hu, Ph.D.
Research Fellow
Genetics Branch

Team Member of:

Thomas Ried, M.D.

Dr. Hu uses statistical and bioinformatics tools to investigate and integrate raw datasets of different types, to recognize statistically significant signals, and to identify the genes and pathways that potentially may be related to cancer development and metastasis.

Areas of Expertise

1) statistical analysis, 2) bioinformatics

Contact Info

Yue Hu, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 50, Room 1408
Bethesda, MD 20892-8010
Ph: 240-760-6372
yue.hu@nih.gov

Oncogenesis results from the alternations of oncogenes and tumor suppressors. Technologies such as microarray, SNP array, Chip-Chip, methylation array and next-generation sequencing iare among the most powerful tools used to study cancer in this lab. These approaches monitor the global profiles of the alternations in DNA sequence, DNA methylation, mRNA expression, etc., providing an enormous amount of information about the mechanism of oncogenesis and metastasis. I utilize different statistic and bioinformatic tools to investigate and integrate these raw datasets of different types, recognize statistically significant signals, and identify the genes and pathways potentially related to cancer development and metastasis. These results will ultimately help us in clinical research as well as drug discovery and development of cancer therapy.

NIH Scientific Focus Areas:
Genetics and Genomics

Selected Recent Publications

  1. Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis .
    Heselmeyer-Haddad KM, Berroa Garcia LY, Bradley A, Hernandez L, Hu Y, Habermann JK, Dumke C, Thorns C, Perner S, Pestova E, Burke C, Chowdhury SA, Schwartz R, Schäffer AA, Paris PL, Ried T.
    Am J Pathol. 184(10): 2671-86, 2014. [ Journal Article ]
  2. LGR5 positivity defines stem-like cells in colorectal cancer.
    Hirsch D, Barker N, McNeil N, Hu Y, Camps J, McKinnon K, Clevers H, Ried T, Gaiser T.
    Carcinogenesis. 35(4): 849-58, 2014. [ Journal Article ]
  3. Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells .
    Padilla-Nash HM, McNeil NE, Yi M, Nguyen QT, Hu Y, Wangsa D, Mack DL, Hummon AB, Case C, Cardin E, Stephens R, Difilippantonio MJ, Ried T.
    Carcinogenesis. 34(8): 1929-39, 2013. [ Journal Article ]
  4. Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression .
    Heselmeyer-Haddad K, Berroa Garcia LY, Bradley A, Ortiz-Melendez C, Lee WJ, Christensen R, Prindiville SA, Calzone KA, Soballe PW, Hu Y, Chowdhury SA, Schwartz R, Schäffer AA, Ried T.
    Am J Pathol. 181(5): 1807-22, 2012. [ Journal Article ]
  5. Molecular patterns in the evolution of serrated lesion of the colorectum.
    Gaiser T, Meinhardt S, Hirsch D, Killian JK, Gaedcke J, Jo P, Ponsa I, Miró R, Rüschoff J, Seitz G, Hu Y, Camps J, Ried T.
    Int J Cancer. 132(8): 1800-10, 2013. [ Journal Article ]