William C. Reinhold, B.S.

William C. Reinhold, B.S.
Facility Head
Developmental Therapeutics Branch
Head, Genomics and Bioinformatics Group

William Reinhold runs the CellMiner website , generates data for inclusion in it, organizes that data in an intuitive fashion, develops the software to facilitate the use of that data, and accesses that data scientifically. CellMiner includes data for the NCI-60 cancerous cell lines, and is a premier systems pharmacology resource, including data from 18 platforms. We provide the unmatched Developmental Therapeutics Program  activity data for 20,002 compounds (including 114 FDA-approved drugs, and 55 in clinical trial). Multiple forms of molecular data is provided. The user may select any of these input parameters of interest (e.g., a gene, drug, microRNA) for cross comparison.

Areas of Expertise

1) pharmacology, 2) website, 3) cancer, 4) pharmacogenomics, 5) molecular data

Contact Info

William C. Reinhold, B.S.
Center for Cancer Research
National Cancer Institute
Building 37, Room 5401
Bethesda, MD 20892-4255
Ph: 240-760-7339
wcr@mail.nih.gov

Currently our research includes the collection of data for the NCI-60 cancerous cell lines, and the development of software to facilitate the use of this data in systems pharmacology. We currently provide easy integration for 20, 602 compounds (including 102 FDA-approved drugs, and 53 in clinical trial), 26,065 genes, and 350 microRNAs. The user selects their input parameter of interest (example: a gene, drug, microRNA, or any other criteria of interest).

Selected Publications

  1. Multifactorial regulation of E-cadherin expression: an integrative study.
    Reinhold WC, Reimers MA, Lorenzi P, Ho J, Shankavaram UT, Ziegler MS, Bussey KJ, Nishizuka S, Ikediobi O, Pommier YG, Weinstein JN.
    Mol. Cancer Ther.. 9: 41655, 2010. [ Journal Article ]
  2. Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron.
    Reinhold WC, Mergny JL, Liu H, Ryan M, Pfister TD, Kinders R, Parchment R, Doroshow J, Weinstein JN, Pommier Y.
    Cancer Res.. 70: 2191-203, 2010. [ Journal Article ]
  3. Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents.
    Zoppoli G, Regairaz M, Leo E, Reinhold WC, Varma S, Ballestrero A, Doroshow JH, Pommier Y.
    Proc. Natl. Acad. Sci. U.S.A.. 109: 15030-5, 2012. [ Journal Article ]
  4. The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology.
    Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, Holbeck SL, Simon RM, Doroshow JH, Pommier Y, Meltzer PS.
    Cancer Res.. 73: 4372-82, 2013. [ Journal Article ]
  5. CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.
    Reinhold WC, Sunshine M, Liu H, Varma S, Kohn KW, Morris J, Doroshow J, Pommier Y.
    Cancer Res.. 72: 3499-511, 2012. [ Journal Article ]

William Reinhold is currently operating as facility head of the Genomics and Bioinformatics Group in the Laboratory of Molecular Pharmacology. He has been a part of this section since April 1998, working with first John N. Weinstein, and then Yves Pommier. He has been central in generating multiple datasets for the NCI-60 cancerous cell lines, available at the CellMiner web-application at http://discover.nci.nih.gov/cellminer/. His activities include running the web site, and maintaining the contracts required to do so, as a Contracting Officer Representative (COR). He helps in the dissemination and interpretation of this data, encouraging and facilitation collaborations. Prior to this period of time he has also held positions with the Laboratory of Molecular Pharmacology (Sept. 1996 to April 1998), Laboratory of Biological Chemistry and Medicine Branch in the NCI (February 1992 - September 1996), at the National Institutes of Neurological Diseases and Stroke (Sept.-1989 to Feb.-1992), National Institutes of Allergies and Infectious Diseases June 1982 to Aug. 1989), as well as in private industry, working for Gibco BRL (April 1981 to Feb. 1982), and Meloy Laboratories (Jan. 1978 to April 1981). He received his B.S. in Biochemistry from the University of Maryland in 1978, and has 66 pier reviewed publications to date.

Name Position
Fathi Elloumi Ph.D. Bioinformatics Specialist (Contr.)
Sudhir Varma Ph.D. Bioinformatics Specialist (Contr.)
Yanghsin (Jeffrey) Wang Bioinformatics Specialist (Contr.)

Genomics and Pharmacology Facility

The Branch's Genomics and Pharmacology Facility manages and assesses molecular interaction data obtained through multiple platforms to increase our understanding of the effect of these interactions on the chemosensitivity of cancer and creates tools that facilitate this process.  Translation of this information will be directed towards the recognition of diagnostic and therapeutic cancer biomarkers and directed cancer therapy.  Learn more... 

The Miner Suite of bioinformatic software packages developed by the Facility are freely available for public use. Visit the links below to learn more about each one.

CellMinerCDB

The CellMiner Cross Database (CDB) enables exploration and analysis of cancer cell line pharmacogenomic data across different sources.  

CellMiner

A database and query tool designed for the cancer research community to facilitate integration of the molecular datasets generated by the Genomic and Parmacology Facility and its collaborators on the NCI-60. Learn more...

CIMminer

A tool that produces Clustered Image Maps (CIMS) (i.e., clustered heat maps). 

GoMiner

A tool that leverages the Gene Ontology (GO) database for biological interpretation of microarray data.  

High-Throughput GoMiner

A tool for batch processing of multiple microarrays and integreated CIMs of the GoMiner results.

MIMminer

A repository of electronically navigatable Kohn Molecular Interaction Maps (MIMs).

MatchMinder

A tool for batch-translation among many types of gene and protein identifiers.

SpliceCenter

A suite of very user-friendly tools designed for use by every bench biologist who needs to check for the impact of gene splice variation on common molecular biology technologies, including RT-PCR, RNAi, expression microarrays, and peptide-based assays.

SpliceMiner

A web application for mapping microarray probes to transcripts in an exon-specific manner.

AbMiner

A tool that allows users to search for appropriate, commercially available antibodies for research purposes, and to match each antibody to its respective genomic identifiers.