Breadcrumb

Euna Yoo, Ph.D.

Euna Yoo, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 538, Room 246
  • Frederick, MD, 21702-1201
  • 301-228-4546
  • euna.yoo@nih.gov
Chemical Biology Laboratory

RESEARCH SUMMARY

Our goal is to discover novel chemical approaches and molecules that can address immunological problems in cancer therapy. Our research applies and advances chemical proteomics to develop new strategies to study and manipulate the human immune system. We use natural product screening and synthetic chemistry to develop chemical probes that specifically detect and perturb key regulators of biochemical and signaling pathways and functional enzymes involved in immune activation and tolerance.

Areas of Expertise

Organic Chemistry
Chemical Immunology
Chemical Proteomics
Biochemistry

Publications

Selected Recent Publications

Covalent Inhibition by a Natural Product-Inspired Latent Electrophile

David P. Byun, Jennifer Ritchie, Yejin Jung, Ronald Holewinski, Hong-Rae Kim, Ravichandra Tagirasa, Joseph Ivanic, Claire M. Weekley, Michael W. Parker, Thorkell Andresson, and Euna Yoo
J. Am Chem Soc. 145/20: 11097–11109, 2023.
Full-Text Article
[ Journal Article ]

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

Euna Yoo, Christopher J Schulze, Barbara H Stokes, Ouma Onguka, Tomas Yeo, Sachel Mok, Nina F Gnädig, Yani Zhou, Kenji Kurita, Ian T Foe, Stephanie M Terrell, Michael J Boucher, Piotr Cieplak, Krittikorn Kumpornsin, Marcus C S Lee, Roger G Linington, Jonathan Z Long, Anne-Catrin Uhlemann, Eranthie Weerapana, David A Fidock, Matthew Bogyo
Cell Chem Biol. 27: 1-15, 2020.
Full-Text Article
[ Journal Article ]

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

Euna Yoo, Barbara H. Stokes, Hanna de Jong, Manu Vanaerschot, TRS Kumar, Nina Lawrence, Mathew Njoroge, Arnold Garcia, Renier Van der Westhuyzen, Jeremiah D. Momper, Caroline L. Ng, David A. Fidock, and Matthew Bogyo
J Am Chem Soc. 140: 11424-11437, 2018.
Full-Text Article
[ Journal Article ]

Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue

Euna Yoo, Alex C. D. Salyer, Michael J. H. Brush, Yupeng Li, Kathryn L. Trautman, Nikunj M. Shukla, Ans De Beuckelaer, Stefan Lienenklaus, Kim Deswarte, Bart N. Lambrecht, Bruno G. De Geest, and Sunil A. David
Bioconjug Chem. 29: 2741-2754, 2018.
Full-Text Article
[ Journal Article ]

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

Hao Li, Anthony J. O’Donoghue, Wouter A. van der Linden, Stanley C. Xie, Euna Yoo, Ian T. Foe, Leann Tilley, Charles S. Craik, Paula C. A. da Fonseca and Matthew Bogyo
Nature. 530: 233-236, 2016.
Full-Text Article
[ Journal Article ]

Job Vacancies

We have no open positions in our group at this time, please check back later.

To see all available positions at CCR, take a look at our Careers page. You can also subscribe to receive CCR's latest job and training opportunities in your inbox.

Team

Postdoctoral Fellow (Visiting)
Yejin Jung, Ph.D.
Kazim
Postdoctoral Fellow (Visiting)
Muhammad Kazim, Ph.D.
Kalyani
Postdoctoral Fellow (Visiting)
Kalyani Thakur, Ph.D.
Davis
Postbaccalaureate Fellow (CRTA)
Griffin Davis, B.S.
Postbaccalaureate Fellow (CRTA)
Sebastian Malespini, B.S.
Postbaccalaureate Fellow (CRTA)
David Zhao, B.S.

News

Learn more about CCR research advances, new discoveries and more
on our news section.

Alumni

Anthony Omole
Anthony Omole
2020-2021
Postbaccalaureate Fellow (CRTA)
Hong-Rae Kim, Ph.D.
Hong-Rae Kim, Ph.D.
2020-2022
Postdoctoral Fellow (Visiting)
Samantha Ono
Samantha Ono
2020-2022
Postbaccalaureate Fellow (CRTA)
David P. Byun
David P. Byun
2020-2022
Postbaccalaureate Fellow (CRTA)
Arghya Ganguly, Ph.D.
Arghya Ganguly, Ph.D.
2020-2022
Postdoctoral Fellow (Visiting)
Ravichandra Tagirasa
Ravichandra Tagirasa
2020-2023
Postdoctoral Fellow (Visiting)
Jennifer Ritchie
Jennifer Ritchie
2021-2023
Postbaccalaureate Fellow (CRTA)
Seth Allen
Seth Allen
2022-2023
Postbaccalaureate Fellow (CRTA)