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Vineet N. KewalRamani, Ph.D.

Vineet N. KewalRamani, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Senior Investigator
Cancer Innovation Laboratory

RESEARCH SUMMARY

Dr. KewalRamani made significant advances in illuminating the role of host factors in HIV infection and the biology of HIV in animal models. Under his direction, the Model Development Section (MDS) examined virus-host interactions at molecular, cellular, and animal levels to better understand HIV immunopathogenesis and the development of antiviral resistance. 

Areas of Expertise

Cancer and Viruses
HIV/AIDS and Related Malignancies
Virus-Host Interactions
Cofactors in HIV Infection
Animal Models for HIV Infection
HIV Pathogenesis

Publications

Selected Key Publications

HIV-1-induced AIDS in monkeys

Hatziioannou T, Del Prete GQ, Keele BF, Estes JD, McNatt MW, Bitzegeio J, Raymond A, Rodriguez A, Schmidt F, Trubey CM, Smedley J, Piatak M, KewalRamani VN, Lifson JD, Bieniasz PD.
Science. 344: 1401-1405, 2014. [ Journal Article ]

Derivation of simian tropic HIV-1 infectious clone reveals virus adaptation to a new host

Schmidt F, Keele BF, Del Prete GQ, Voronin D, Fennessey CM, Soll S, Kane M, Raymond A, Gifford RJ, KewalRamani V, Lifson JD, Bieniasz PD, Hatziioannou T.
Proc Natl Acad Sci U S A. 116(21): 10504-9, 2019. [ Journal Article ]

A single gp120 residue can affect HIV-1 tropism in macaques

Del Prete GQ, Keele BF, Fode J, Thummar K, Swanstrom AE, Rodriguez A, Raymond A, Estes JD, LaBranche CC, Montefiori DC, KewalRamani VN, Lifson JD, Bieniasz PD, Hatziioannou T.
PLoS Pathog. 13(9): e1006572, 2017. [ Journal Article ]

STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

Gres AT, Kirby KA, KewalRamani VN, Tanner JJ, Pornillos O, Sarafianos SG.
Science. 349(6243): 99-103, 2015. [ Journal Article ]

Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins

Del Prete GQ, Ailers B, Moldt B, Keele BF, Estes JD, Rodriguez A, Sampias M, Oswald K, Fast R, Trubey CM, Chertova E, Smedley J, LaBranche CC, Montefiori DC, Burton DR, Shaw GM, Markowitz M, Piatak M Jr, KewalRamani VN, Bieniasz PD, Lifson JD, Hatziioannou T.
Cell Host Microbe. 16(3): 412-8, 2014. [ Journal Article ]

Biography

Vineet N. KewalRamani, Ph.D.
Senior Investigator

Vineet N. KewalRamani, Ph.D.

Dr. Vineet N. KewalRamani first developed an interest in retroviruses as an undergraduate in the University of Wisconsin at Madison. After choosing to pursue molecular biology as a career, he enrolled in the graduate program at the University of Washington in Seattle where he studied HIV molecular replication at the Fred Hutchinson Cancer Research Center. Upon completing his Ph.D. training in 1996, he received a fellowship from the Damon Runyon Cancer Research Foundation and a postdoctoral position from New York University where he examined HIV infection within an immunological context. While working in NYU, he joined in an effort to develop a mouse model for HIV replication using transgenic technologies. These studies provided the foundation for his group's current work at the National Cancer Institute. Today, his team investigates the role of host factors in HIV infection and the biology of HIV in animal models. HIV and other retroviruses hack the host organism's genetic program to propagate their code. They also rapidly evolve in the face of selective pressure. By illuminating how retroviruses co-opt host functions while evading antiviral drugs or immune responses, his lab seeks to develop new strategies to impede the dynamic viral program. Dr. KewalRamani was the 2011 and 2012 chair of the National Institutes of Health (NIH) Earl Stadtman Virology Search Committee and a co-organizer of the Cold Spring Harbor Laboratory 37th annual meeting on Retroviruses held in May of 2012. He is a past chair of the NIH Norman Salzman Virology Scientific Committee. He has served on the editorial boards of Journal of Virology, PLoS ONE, Retrovirology, and Virology. He was tenured by the NIH in 2010.