Stephanie L. Goff, M.D.
Staff Clinician

Center for Cancer Research
National Cancer Institute

Building 10 - Hatfield Clinical Research Center, Room 3-5840
Bethesda, MD 20892
301-451-6945

As a member of the Vector Production Lab, my projects have focused on the bench-to-bedside transfer of T cell receptor gene therapy. Primary focus has been in vitro testing of new therapeutic vectors. Secondary focus has been facilitating the technology transfer of the retroviral production process from the National Gene Vector Laboratory to the NCI Surgery Branch facility. A new focus will be the transfer of a lentiviral production process into the Surgery Branch.

Areas of Expertise
gene therapy

As a member of the Vector Production Lab, my projects have focused on the bench-to-bedside transfer of T cell receptor gene therapy. Primary focus has been in vitro testing of new therapeutic vectors. Secondary focus has been facilitating the technology transfer of the retroviral production process from the National Gene Vector Laboratory to the NCI Surgery Branch facility.

A new focus will be the transfer of a lentiviral production process into the Surgery Branch.

Selected Publications
  1. Heemskerk B, Liu K, Dudley ME, Johnson LA, Kaiser A, Downey S, Zheng Z, Shelton TE, Matsuda K, Robbins PF, Morgan RA, Rosenberg SA.
    Hum. Gene Ther.. 19: 496-510, 2008. [ Journal Article ]
  2. Dudley ME, Yang JC, Sherry R, Hughes MS, Royal R, Kammula U, Robbins PF, Huang J, Citrin DE, Leitman SF, Wunderlich J, Restifo NP, Thomasian A, Downey SG, Smith FO, Klapper J, Morton K, Laurencot C, White DE, Rosenberg SA.
    J. Clin. Oncol.. 2008. [ Journal Article ]
  3. Klapper JA, Downey SG, Smith FO, Yang JC, Hughes MS, Kammula US, Sherry RM, Royal RE, Steinberg SM, Rosenberg S.
    Cancer. 113: 293-301, 2008. [ Journal Article ]
  4. Wargo JA, Robbins PF, Li Y, Zhao Y, El-Gamil M, Caragacianu D, Zheng Z, Hong JA, Downey S, Schrump DS, Rosenberg SA, Morgan RA.
    Cancer Immunol. Immunother.. 2008. [ Journal Article ]
  5. Smith FO, Downey SG, Klapper JA, Yang JC, Sherry RM, Royal RE, Kammula US, Hughes MS, Restifo NP, Levy CL, White DE, Steinberg SM, Rosenberg SA.
    Clin. Cancer Res.. 14: 5610-8, 2008. [ Journal Article ]

1998 - Bachelor of Mechanical Engineering - Georgia Institute of Technology, Atlanta, GA 2003 - Doctor of Medicine - University of South Florida College of Medicine, Tampa, FL 2004-2005 - Surgical Internship/Residency - St. Vincent's Catholic Medical Center - Manhattan, NY, NY 2005-2006 - Clinical Immunotherapy Fellow - NCI, Surgery Branch, Bethesda, MD 2006-present - Surgical Oncology Fellow - NCI, Surgery Branch, Bethesda, MD

Summary

As a member of the Vector Production Lab, my projects have focused on the bench-to-bedside transfer of T cell receptor gene therapy. Primary focus has been in vitro testing of new therapeutic vectors. Secondary focus has been facilitating the technology transfer of the retroviral production process from the National Gene Vector Laboratory to the NCI Surgery Branch facility. A new focus will be the transfer of a lentiviral production process into the Surgery Branch.

Areas of Expertise
gene therapy

Research

As a member of the Vector Production Lab, my projects have focused on the bench-to-bedside transfer of T cell receptor gene therapy. Primary focus has been in vitro testing of new therapeutic vectors. Secondary focus has been facilitating the technology transfer of the retroviral production process from the National Gene Vector Laboratory to the NCI Surgery Branch facility.

A new focus will be the transfer of a lentiviral production process into the Surgery Branch.

Publications

Selected Publications
  1. Heemskerk B, Liu K, Dudley ME, Johnson LA, Kaiser A, Downey S, Zheng Z, Shelton TE, Matsuda K, Robbins PF, Morgan RA, Rosenberg SA.
    Hum. Gene Ther.. 19: 496-510, 2008. [ Journal Article ]
  2. Dudley ME, Yang JC, Sherry R, Hughes MS, Royal R, Kammula U, Robbins PF, Huang J, Citrin DE, Leitman SF, Wunderlich J, Restifo NP, Thomasian A, Downey SG, Smith FO, Klapper J, Morton K, Laurencot C, White DE, Rosenberg SA.
    J. Clin. Oncol.. 2008. [ Journal Article ]
  3. Klapper JA, Downey SG, Smith FO, Yang JC, Hughes MS, Kammula US, Sherry RM, Royal RE, Steinberg SM, Rosenberg S.
    Cancer. 113: 293-301, 2008. [ Journal Article ]
  4. Wargo JA, Robbins PF, Li Y, Zhao Y, El-Gamil M, Caragacianu D, Zheng Z, Hong JA, Downey S, Schrump DS, Rosenberg SA, Morgan RA.
    Cancer Immunol. Immunother.. 2008. [ Journal Article ]
  5. Smith FO, Downey SG, Klapper JA, Yang JC, Sherry RM, Royal RE, Kammula US, Hughes MS, Restifo NP, Levy CL, White DE, Steinberg SM, Rosenberg SA.
    Clin. Cancer Res.. 14: 5610-8, 2008. [ Journal Article ]

Biography

1998 - Bachelor of Mechanical Engineering - Georgia Institute of Technology, Atlanta, GA 2003 - Doctor of Medicine - University of South Florida College of Medicine, Tampa, FL 2004-2005 - Surgical Internship/Residency - St. Vincent's Catholic Medical Center - Manhattan, NY, NY 2005-2006 - Clinical Immunotherapy Fellow - NCI, Surgery Branch, Bethesda, MD 2006-present - Surgical Oncology Fellow - NCI, Surgery Branch, Bethesda, MD