Stephanie L. Goff, M.D.
Staff Clinician

As a member of Dr. Rosenberg's senior staff, I share responsibility for the care and management of patients receiving cell-based immunotherapy for the treatment of metastatic solid tumors on protocols established by the Surgery Branch. These patients have a variety of malignancies (melanoma, ovarian, breast, gastrointestinal, sarcoma, etc.). My research is focused on the use of adoptive cell transfer in patients with metastatic breast cancer, based on a system of identifying non-synonymous mutations within an individual tumor and evaluating the ability of that patient's lymphocytes to recognize the mutation in vitro.

Areas of Expertise
1) immunotherapy, 2) melanoma, 3) breast cancer, 4) surgical oncology

Contact Info

Stephanie L. Goff, M.D.
Center for Cancer Research
National Cancer Institute
Building 10 - Hatfield Clinical Research Center, Room 3-5840
Bethesda, MD 20892
301-451-6945
stephanie.goff@nih.gov

We are evaluating tumor-infiltrating lymphocytes in tumors removed from patients with metastatic breast cancer, developing methods to explore adoptive cell transfer for this patient population. In addition to genomic studies to evaluate non-synonymous mutations, we are also exploring the development of T-cell receptors for future opportunities to explore gene-engineered peripheral blood lymphocytes (PBL) for clinical use.

Scientific Focus Areas:
Immunology
Selected Publications
  1. Goff SL, Smith FO, Klapper JA, Sherry R, Wunderlich JR, Steinberg SM, White D, Rosenberg SA, Dudley ME, Yang JC.
    J Immunother. 33: 840-7, 2010. [ Journal Article ]
  2. Goff SL, Johnson LA, Black MA, Xu H, Zheng Z, Cohen CJ, Morgan RA, Rosenberg SA, Feldman SA.
    Cancer Immunol Immunother. 59: 1551-60, 2010. [ Journal Article ]
  3. Downey SG, Klapper JA, Smith FO, Yang JC, Sherry RM, Royal RE, Kammula US, Hughes MS, Allen TE, Levy CL, Yellin M, Nichol G, White DE, Steinberg SM, Rosenberg SA. ,
    Clin Cancer Res. 13(22 Pt 1): 6681-8, 2007. [ Journal Article ]
  4. Heemskerk B, Liu K, Dudley ME, Johnson LA, Kaiser A, Downey S, Zheng Z, Shelton TE, Matsuda K, Robbins PF, Morgan RA, Rosenberg SA.
    Hum Gene Ther. 19: 496-510, 2008. [ Journal Article ]
  5. Dudley ME, Yang JC, Sherry R, Hughes MS, Royal R, Kammula U, Robbins PF, Huang J, Citrin DE, Leitman SF, Wunderlich J, Restifo NP, Thomasian A, Downey SG, Smith FO, Klapper J, Morton K, Laurencot C, White DE, Rosenberg SA.
    J Clin Oncol. 26: 5233-9, 2008. [ Journal Article ]

Stephanie Goff is a surgeon on the senior staff of the Surgery Branch of the National Cancer Institute at the NIH. Her research interests include adoptive cell therapy for the treatment of solid tumors, building on the backbone of success in patients with metastatic melanoma to investigate the strategy in patients with metastastic breast cancer. Her publications range from analysis of early trials of checkpoint blockade to genetic modifications of T-cell receptors. After training in tumor immunology under Dr. Steven Rosenberg, Dr. Goff completed her general  surgery residency at Columbia University followed by a surgical oncology fellowship at the combined Dana-Farber Cancer Institute/Brigham and Women’s Hospital/Massachusetts General Hospital program.

Research

We are evaluating tumor-infiltrating lymphocytes in tumors removed from patients with metastatic breast cancer, developing methods to explore adoptive cell transfer for this patient population. In addition to genomic studies to evaluate non-synonymous mutations, we are also exploring the development of T-cell receptors for future opportunities to explore gene-engineered peripheral blood lymphocytes (PBL) for clinical use.

Scientific Focus Areas:
Immunology

Publications

Selected Publications
  1. Goff SL, Smith FO, Klapper JA, Sherry R, Wunderlich JR, Steinberg SM, White D, Rosenberg SA, Dudley ME, Yang JC.
    J Immunother. 33: 840-7, 2010. [ Journal Article ]
  2. Goff SL, Johnson LA, Black MA, Xu H, Zheng Z, Cohen CJ, Morgan RA, Rosenberg SA, Feldman SA.
    Cancer Immunol Immunother. 59: 1551-60, 2010. [ Journal Article ]
  3. Downey SG, Klapper JA, Smith FO, Yang JC, Sherry RM, Royal RE, Kammula US, Hughes MS, Allen TE, Levy CL, Yellin M, Nichol G, White DE, Steinberg SM, Rosenberg SA. ,
    Clin Cancer Res. 13(22 Pt 1): 6681-8, 2007. [ Journal Article ]
  4. Heemskerk B, Liu K, Dudley ME, Johnson LA, Kaiser A, Downey S, Zheng Z, Shelton TE, Matsuda K, Robbins PF, Morgan RA, Rosenberg SA.
    Hum Gene Ther. 19: 496-510, 2008. [ Journal Article ]
  5. Dudley ME, Yang JC, Sherry R, Hughes MS, Royal R, Kammula U, Robbins PF, Huang J, Citrin DE, Leitman SF, Wunderlich J, Restifo NP, Thomasian A, Downey SG, Smith FO, Klapper J, Morton K, Laurencot C, White DE, Rosenberg SA.
    J Clin Oncol. 26: 5233-9, 2008. [ Journal Article ]

Biography

Stephanie Goff is a surgeon on the senior staff of the Surgery Branch of the National Cancer Institute at the NIH. Her research interests include adoptive cell therapy for the treatment of solid tumors, building on the backbone of success in patients with metastatic melanoma to investigate the strategy in patients with metastastic breast cancer. Her publications range from analysis of early trials of checkpoint blockade to genetic modifications of T-cell receptors. After training in tumor immunology under Dr. Steven Rosenberg, Dr. Goff completed her general  surgery residency at Columbia University followed by a surgical oncology fellowship at the combined Dana-Farber Cancer Institute/Brigham and Women’s Hospital/Massachusetts General Hospital program.