Siddhartha A.K. Datta, Ph.D.

Siddhartha A.K. Datta, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Evolution of drug-resistant human immunodeficiency virus (HIV) is a serious clinical issue that necessitates the design of new drugs against current targets, as well as against previously untargeted stages of the viral life cycle. We use a combination of biophysical, biochemical, and molecular biology techniques to dissect the mechanisms involved in retroviral assembly, with special emphasis on HIV. We hope that basic insights gained into the assembly mechanism(s) could provide a foundation for the design of assembly inhibitors.

Areas of Expertise

Protein Biochemistry
Optical Spectroscopy
Mass Spectroscopy
Analytical Centrifugation


Selected Key Publications

Solution properties of murine leukemia virus gag protein: differences from HIV-1 gag

Datta SA, Zuo X, Clark PK, Campbell SJ, Wang YX, Rein A.
J. Virol. 85: 12733-41, 2011. [ Journal Article ]

Diverse interactions of retroviral Gag proteins with RNAs

Rein A, Datta SA, Jones CP, Musier-Forsyth K.
Trends Biochem. Sci. 36: 373-80, 2011. [ Journal Article ]

On the role of the SP1 domain in HIV-1 particle assembly: a molecular switch?

Datta SA, Temeselew LG, Crist RM, Soheilian F, Kamata A, Mirro J, Harvin D, Nagashima K, Cachau RE, Rein A.
J. Virol. 85: 4111-21, 2011. [ Journal Article ]

HIV-1 Gag extension: conformational changes require simultaneous interaction with membrane and nucleic acid

Datta SA, Heinrich F, Raghunandan S, Krueger S, Curtis JE, Rein A, Nanda H.
J. Mol. Biol. 406: 205-14, 2011. [ Journal Article ]

Conformation of the HIV-1 Gag protein in solution.

Datta SA, Curtis JE, Ratcliff W, Clark PK, Crist RM, Lebowitz J, Krueger S, Rein A.
J. Mol. Biol. 365: 812-24, 2007. [ Journal Article ]