Breadcrumb

Bruce M. Paterson, Ph.D.

Bruce M. Paterson, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Paterson pioneered the use of cell-free protein synthesis systems in the analysis of gene function. He co-developed the wheat-germ cell-free protein synthesis system, one of the first methods used to analyze functional mRNA levels in normal and transformed cells and tissues. He was a major contributor to the study of myogenesis in both vertebrates and in Drosophila, and was one of the first to demonstrate RNAi knock-down to study gene function during Drosophila development. He demonstrated that tissue-specific microRNA regulatory networks buffer gene function critical to cell homeostasis and differentiation, where the disruption of either can lead to cell transformation and cancer.

Areas of Expertise

1) cell-free protein synthesis 2) myogenesis 3) Drosophila development 4) RNAi gene knock-down 5) micro RNA circuitry 6) siRNA function

Publications

Selected Key Publications

Efficient translation of tobacco mosaic virus RNA and rabbit globin 9S RNA in a cell-free system from commercial wheat germ

Roberts BE, Paterson BM.
Proc. Natl. Acad. Sci. U.S.A. 70: 2330-4, 1973. [ Journal Article ]

Changes in the mRNA population of chick myoblasts during myogenesis in vitro

Paterson BM, Bishop JO.
Cell. 12: 751-65, 1977. [ Journal Article ]

Molecular cloning of a gene sequence regulated by nerve growth factor

Levi A, Eldridge JD, Paterson BM.
Science. 229: 393-5, 1985. [ Journal Article ]

Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): a role for nautilus in embryonic somatic muscle formation

Misquitta L, Paterson BM.
Proc. Natl. Acad. Sci. U.S.A. 96: 1451-6, 1999. [ Journal Article ]

Stereotypic founder cell patterning and embryonic muscle formation in Drosophila require nautilus (MyoD) gene function

Wei Q, Rong Y, Paterson BM.
Proc. Natl. Acad. Sci. U.S.A. 104: 5461-6, 2007. [ Journal Article ]