zhihui liu

Zhihui Liu, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Pediatric Oncology Branch


Dr. Liu’s research interest is in the field of cancer biology, in particular to obtain an understanding of the molecular mechanisms involved in neuroblastoma (NB) tumorigenesis and progression. His main focus is to investigate the transcriptional dysregulation that contribute to the malignancy of NB. Through high-throughput screening of dysregulated transcription factors and epigenetic regulators in NB, Dr. Liu aims to identify novel therapeutic targets that could benefit the NB patients.

Areas of Expertise

Cancer Biology
Pediatric Cancer Neuroblastoma And Rhabdomyosarcoma
Transcriptional Regulation


Selected Publications

CASZ1 induces skeletal muscle and embryonal rhabdomyosarcoma differentiation via formation of a feed-forward differentiation loop with MYOD and MYOG.

1. Liu Z, Zhang X, Lei H, Lam N, Yockey O, Xu M, Mendoza A, Hernandez E, Wei JS, Khan J, Yohe ME, Shern JF and Thiele CJ.
Nat Commun. 11: 2020. [ Journal Article ]

Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy for p53 activation in high-risk neuroblastoma.

Veschi V, Liu Z, Voss TC, Ozbun L, Gryder B, Yan C, Hu Y, Ma A, Jin J, Mazur SJ, Lam N, Souza BK, Giannini G, Hager GL, Arrowsmith CH, Khan J, Appella E and Thiele CJ.
Cancer Cell. 31: 50-63, 2017. [ Journal Article ]

Identification of CASZ1 NES reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma.

Liu Z, Lam N, Wang E, Virden RA, Pawel B, Attiyeh EF, Maris JM and Thiele CJ.
Oncogene. 36: 97-108, 2017. [ Journal Article ]

Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.

Liu Z, Li W, Ma X, Ding N, Spallotta F, Southon E, Tessarollo L, Gaetano C, Mukouyama YS and Thiele CJ.
J Biol Chem. 289: 29801-16, 2014. [ Journal Article ]

CASZ1, a candidate tumor suppressor suppresses neuroblastoma tumor growth through reprogramming gene expression.

Liu Z, Yang X, Li Z, McMahon C, Sizer C, Barenboim-Stapleton L, Bliskovsky V, Mock B, Ried T, London WB, Maris J, Khan J, Thiele CJ .
Cell Death Differ. 18: 1174-83, 2011. [ Journal Article ]

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