Girma M. Woldemichael, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 567, Room 221A
- Frederick, MD 21702-1201
- 301-846-5556
- woldemichaelg@mail.nih.gov
RESEARCH SUMMARY
High throughput screening represents an attractive route for the discovery of modulators of newly discovered targets in cancer and other diseases. An area of my research focus is the development of validated cell-based high throughput screening assays for the discovery of modulators of such targets. Emphasis is given to discovery of modulators from natural products (plants, marine- and micro-organisms) through the design of natural products compatible screening assays. The biological characterization of screen hits through the elucidation mechanisms and/or modes of action is another area of my research focus. My work encompasses the intersection of various disciplines including natural products chemistry, molecular and cellular biology,and high throughput automation.
Areas of Expertise
1) high-throughput screening
Girma M. Woldemichael, Ph.D.
Research
High throughput screening represents an attractive route for the discovery of modulators of newly discovered targets in cancer and other diseases. An area of my research focus is the development of validated cell-based high throughput screening assays for the discovery of modulators of such targets. Emphasis is given to discovery of modulators from natural products (plants, marine- and micro-organisms) through the design of natural products compatible screening assays. The biological characterization of screen hits through the elucidation mechanisms and/or modes of action is another area of my research focus. My work encompasses the intersection of various disciplines including natural products chemistry, molecular and cellular biology,and high throughput automation.
Publications
Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells
Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening
Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia
Characterization of two mouse models of metastatic pheochromocytoma using bioluminescence imaging
Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A
Biography
Girma M. Woldemichael, Ph.D.
Dr. Woldemichael received his Ph.D. in pharmaceutical chemical biology from Heidelberg University (Germany) and conducted postdoctoral research at the University of Arizona and at the NCI. He joined the Molecular Targets Program in 2007 as a Scientist affiliated with Leidos Biomedical Research, Inc.