Girma M. Woldemichael, Ph.D.

Girma M. Woldemichael, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


High throughput screening represents an attractive route for the discovery of modulators of newly discovered targets in cancer and other diseases. An area of my research focus is the development of validated cell-based high throughput screening assays for the discovery of modulators of such targets. Emphasis is given to discovery of modulators from natural products (plants, marine- and micro-organisms) through the design of natural products compatible screening assays. The biological characterization of screen hits through the elucidation mechanisms and/or modes of action is another area of my research focus. My work encompasses the intersection of various disciplines including natural products chemistry, molecular and cellular biology,and high throughput automation.

Areas of Expertise

High-throughput Screening


Selected Publications

Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells

Woldemichael GM, Turbyville TJ, Linehan WM, McMahon JB.
Cancer Res.. 71: 134-42, 2011. [ Journal Article ]

Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening

Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ.
J. Natl. Cancer Inst.. 103: 962-78, 2011. [ Journal Article ]

Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia

Meragelman TL, Willis RH, Woldemichael GM, Heaton A, Murphy PT, Snader KM, Newman DJ, van Soest R, Boyd MR, Cardellina JH, McKee TC.
J. Nat. Prod.. 70: 1133-8, 2007. [ Journal Article ]

Characterization of two mouse models of metastatic pheochromocytoma using bioluminescence imaging

Giubellino A, Woldemichael GM, Sourbier C, Lizak MJ, Powers JF, Tischler AS, Pacak K.
Cancer Lett.. 316: 46-52, 2012. [ Journal Article ]

Lack of a functional VHL gene product sensitizes renal cell carcinoma cells to the apoptotic effects of the protein synthesis inhibitor verrucarin A

Woldemichael GM, Turbyville TJ, Vasselli JR, Linehan WM, McMahon JB.
Neoplasia. 14: 771-7, 2012. [ Journal Article ]