Joel P. Schneider, Ph.D.
Joel P. Schneider, Ph.D.
Chief
Head, Peptide Design and Materials Section

Center for Cancer Research
National Cancer Institute

Building 376, Room 104
Frederick, MD 21702-1201
301-846-5954

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.

Link to additional information about Dr. Schneider’s research.

Areas of Expertise
1) peptides 2) materials science 3) hydrogels 4) chemical biology 5) organic synthesis 6) tissue engineering

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.

Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Chemical Biology, Molecular Biology and Biochemistry
Selected Key Publications
  1. Schneider JP, Pochan DJ, Ozbas B, Rajagopal K, Pakstis L, Kretsinger J.
    J. Am. Chem. Soc. 124: 15030-7, 2002. [ Journal Article ]
  2. Haines-Butterick L, Rajagopal K, Branco M, Salick D, Rughani R, Pilarz M, Lamm MS, Pochan DJ, Schneider JP.
    Proc. Natl. Acad. Sci. U.S.A. 104: 7791-6, 2007. [ Journal Article ]
  3. Sinthuvanich C, Veiga AS, Gupta K, Gaspar D, Blumenthal R, Schneider JP.
    J. Am. Chem. Soc. 134: 6210-7, 2012. [ Journal Article ]
  4. Nagy KJ, Giano MC, Jin A, Pochan DJ, Schneider JP.
    J. Am. Chem. Soc. 133: 14975-7, 2011. [ Journal Article ]
  5. Schneider JP.
    Nat. Commun. 5: 4095, 2014. [ Journal Article ]

Dr. Schneider received his Ph.D. in Organic Chemistry from Texas A&M University with Jeffery Kelly and then went on to the University of Pennsylvania School of Medicine, Department of Biochemistry and Biophysics where he was a George W. Raiziss Fellow with William DeGrado studying protein design. In 1999, he began his independent career at the University of Delaware as an assistant professor of Chemistry and Biochemistry and was promoted to associate and then full professor in 2009 with a secondary appointment in Materials Science and Engineering. He joined the NCI in 2010 as lab Chief of the newly established Chemical Biology Laboratory. He currently serves as Editor in Chief of Biopolymers-Peptide Science, the journal of the American Peptide Society.

Name Position
Poulami Majumder Postdoctoral Fellow (CRTA)
Scott Medina Ph.D. Postdoctoral Fellow (CRTA)
Stephen Miller Ph.D. Postdoctoral Fellow (CRTA)
Katelyn J. Nagy Predoctoral Fellow
Emily Sevcik Summer Student
Yuji Yamada Ph.D. Postdoctoral Fellow (Visiting)

Summary

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.

Link to additional information about Dr. Schneider’s research.

Areas of Expertise
1) peptides 2) materials science 3) hydrogels 4) chemical biology 5) organic synthesis 6) tissue engineering

Research

The Schneider group designs and characterizes novel materials for use in tissue regenerative therapy, parenteral delivery of therapeutics, delivery of cells, and antibacterial therapy. We are particularly interested in peptide and protein-based hydrogel materials formed by self-assembly mechanisms. Our work spans molecular conception, materials synthesis, nano- and bulk mechanical materials characterization, cell-material interactions, biocompatibility, and assessment of performance efficacy. Our basic research establishes how material composition and structure influences material function, and lays the foundation to ultimately translate materials to the clinic.

Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Chemical Biology, Molecular Biology and Biochemistry

Publications

Selected Key Publications
  1. Schneider JP, Pochan DJ, Ozbas B, Rajagopal K, Pakstis L, Kretsinger J.
    J. Am. Chem. Soc. 124: 15030-7, 2002. [ Journal Article ]
  2. Haines-Butterick L, Rajagopal K, Branco M, Salick D, Rughani R, Pilarz M, Lamm MS, Pochan DJ, Schneider JP.
    Proc. Natl. Acad. Sci. U.S.A. 104: 7791-6, 2007. [ Journal Article ]
  3. Sinthuvanich C, Veiga AS, Gupta K, Gaspar D, Blumenthal R, Schneider JP.
    J. Am. Chem. Soc. 134: 6210-7, 2012. [ Journal Article ]
  4. Nagy KJ, Giano MC, Jin A, Pochan DJ, Schneider JP.
    J. Am. Chem. Soc. 133: 14975-7, 2011. [ Journal Article ]
  5. Schneider JP.
    Nat. Commun. 5: 4095, 2014. [ Journal Article ]

Biography

Dr. Schneider received his Ph.D. in Organic Chemistry from Texas A&M University with Jeffery Kelly and then went on to the University of Pennsylvania School of Medicine, Department of Biochemistry and Biophysics where he was a George W. Raiziss Fellow with William DeGrado studying protein design. In 1999, he began his independent career at the University of Delaware as an assistant professor of Chemistry and Biochemistry and was promoted to associate and then full professor in 2009 with a secondary appointment in Materials Science and Engineering. He joined the NCI in 2010 as lab Chief of the newly established Chemical Biology Laboratory. He currently serves as Editor in Chief of Biopolymers-Peptide Science, the journal of the American Peptide Society.

Team

Name Position
Poulami Majumder Postdoctoral Fellow (CRTA)
Scott Medina Ph.D. Postdoctoral Fellow (CRTA)
Stephen Miller Ph.D. Postdoctoral Fellow (CRTA)
Katelyn J. Nagy Predoctoral Fellow
Emily Sevcik Summer Student
Yuji Yamada Ph.D. Postdoctoral Fellow (Visiting)