Job Description
A postdoctoral position is open for an exciting project focused on the role of androgen signaling in neutrophil function and bone metastatic prostate cancer.
The Cook Lab research is investigating cellular interactions within the tumor bone microenvironment that contribute to tumor progression, with a specific focus on neutrophil-tumor interactions. Within bone, metastatic cancer cells highjack the normal couple process of bone remodeling, resulting in excess bone degradation and subsequent release of growth factors that promote tumor growth. Additionally, cancer cells progress and mediate bone turnover through molecular and cellular interactions with the surrounding bone stroma. The Cook lab is using a combination of transcriptome and proteomic profiling of patient samples and mouse in vivo models of bone metastasis along with sophisticated bone and live-cell imaging tools.
The Cook Lab is adjacent to other CIL groups studying immune metabolism and metastasis, such as the McVicar and Wink labs, and novel 3D models (Wolf Lab). The CIL is an exciting community studying cutting edge research in many focus areas.
Qualifications and Job Details
Required and Preferred Skills
- Cancer and/or immunology research experience required
- Experience with mice preferred but not required
- Bone experience ideal but not required
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Frederick
Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.