Signaling from Eph receptor tyrosine kinases and the ephrin transmembrane ligands affect morphogenesis during development and have been shown to play an instructive role in angiogenesis, as well as tumor cell invasion. Since we found a connection between the key Wnt signaling scaffold, Dishevelled, and ephrinB proteins, we have extended our analysis to examine how the intersection of Wnt/Planar Cell Polarity (PCP) and ephrinB signaling alters the mechanisms of signal transduction of these pathways. Moreover, we investigate how the output of these pathways lead to the creation of highly ordered intricate structures during development. Both Xenopus (Frog) and mammalian tissue culture systems are employed in projects that involve the functional and molecular characterization of the cellular and developmental effects mediated by the ephrinB and Wnt pathway proteins.
A postdoctoral position is available in 2022 to study the role of ephrin and Wnt signaling pathways in cell movement and morphogenesis. A combination of molecular, cell biological, and biochemical techniques are applied in the amphibian developmental and mammalian culture systems. See recent publications: Sun et al., EMBO Rep. 2022; Lee et al., J. Cell Biol 2022; Yoon et al., Development 2021; Lee et al., J. Cell Biol. 2019; Yoon et al., Nature Comm. 2018).
Qualifications and Job Details
Required and Preferred Skills
A strong background in molecular, cellular, or developmental biology is required. Interested candidates should have a Ph.D. and/or an M.D. and have less than 5 years postdoctoral experience.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.
Our laboratory is located at the NCI-Frederick campus and offers state-of-the-art facilities in an exciting environment for postdoctoral research. The NCI offers competitive postdoctoral stipends. Qualifying fellows from abroad will be provided a J-1 Visa.