Changqing Xie, M.D., Ph.D.

I am interested in exploring the potential mechanism of resistance to treatment with immune checkpoint inhibitor in gastrointestinal (GI) malignancy. My focus is to dissect the role of cancer stem cells in cholangiocarcinoma in terms of developing this therapy resistance.
1) gastrointestinal (GI) malignancy, 2) cancer stem cells, 3) cholangiocarcinoma,
4) immune checkpoint inhibitor
Contact Info
Center for Cancer Research
National Cancer Institute
Building 10, Room 3B43
Bethesda, Maryland 20892
Ph: 301-646-8337
changqing.xie@nih.gov
My overall goal is to explore the role of cancer stem cells in the development of treatment resistance to immunotherapy in cholangiocarcinoma with the following steps: 1) To investigate the path of cancer stem cells during cholangiocarcinoma; 2) To study the interaction between cancer stem cells and neighboring immune cells during cholangiocarcinoma pathogenesis; and 3) To identify the potential target agents to control cancer stem cells in cholangiocarcinoma.
Selected Recent Publications
- Clin Cancer Res. 26(10): 26(10):2318-26, 2020. [ Journal Article ]
- Clin Colorectal Cancer. 18(4): e349-e360, 2019. [ Journal Article ]
- Hepatology. 69(5): 2048-60, 2019. [ Journal Article ]
- Cancer Immunol Immunother. 68(4): 599-608, 2019. [ Journal Article ]
- J Endocr Soc. 3(1): 284-90, 2018. [ Journal Article ]
I received my M.D. and Ph.D from the Xiangya School of Medicine of Central South University. I completed my postdoctoral training at Morehouse School Medicine and at the University of Michigan before being promoted as junior faculty at the University of Michigan. Before I started internal medicine residency training at East Carolina University, I worked as an Assistant Research Professor at the University of Virginia. I completed hematology oncology training through the NHLBI/NCI Hematology Oncology Fellowship program and joined the Thoracic and Gastrointestinal (GI) Malignancies Branch as an Assistant Clinical Investigator in 2019.
Name | Position |
---|---|
Claude Fu | Postdoctoral Fellow |
Nicole A. McGrath | Postbaccalaureate Fellow (CRTA) |