National Cancer Institute - Cancer.gov

Supreet Agarwal, Ph.D.

Supreet Agarwal, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Genitourinary Cancer Pathogenesis

RESEARCH SUMMARY

Dr. Agarwal is a cancer biologist with diverse expertise in clinical pharmaceutical sciences, cancer stem cells and therapeutics, and biomarker-enabled drug discovery. His current research focuses on mechanism-based translational cancer research, preclinical trials, and biomarker discovery of drug response/resistance using clinically relevant 3D organoid models, patient biopsies, and xenografts (PDXs) of metastatic prostate cancer.

Areas of Expertise

1) cancer stem cells 2) genomic and transcriptomic analysis 3) biomarker discovery 4) mechanisms of drug resistance 5) organoid culture

Publications

Selected Key Publications

A genotoxic antibody drug conjugate targeting CD276/B7H3 demonstrates efficacy across multiple biomarker defined classes of treatment refractory metastatic prostate cancer

Agarwal S, Fang L, McGowen K, Yin JJ, Bowman J, Ku AT, Alilin AN, Corey E, Roudier M, True L, Dumpit R, Coleman I, Lee J, Nelson PS, Capaldo BJ, Senatorov IS, Sowalsky AG, Hurt AM, Kelly K
2022.
Full-Text Article
[ Journal Article ]

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

Baca SC, Takeda DY, Seo JH, Hwang J, Ku SY, Arafeh R, Arnoff T, Agarwal S, Bell C, O'Connor E, Qiu X, Alaiwi SA, Corona RI, Fonseca MAS, Giambartolomei C, Cejas P, Lim K, He M, Sheahan A, Nassar A, Berchuck JE, Brown L, Nguyen HM, Coleman IM, Kaipainen A, De Sarkar N, Nelson PS, Morrissey C, Korthauer K, Pomerantz MM, Ellis L, Pasaniuc B, Lawrenson K, Kelly K, Zoubeidi A, Hahn WC, Beltran H, Long HW, Brown M, Corey E, Freedman ML
Nat Commun. Mar 30;12(1):1979: 2020. [ Journal Article ]

A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening

Beshiri ML, Tice CM, Tran C, Nguyen HM, Sowalsky AG, Agarwal S, Jansson KH, Yang Q, McGowen KM, Yin J, Alilin AN, Karzai FH, Dahut WL, Corey E, Kelly K
Clin Cancer Res. Sep 1;24(17): 4332-4345, 2018. [ Journal Article ]

Targeting the PI3K/AKT Pathway Overcomes Enzalutamide Resistance by Inhibiting Induction of the Glucocorticoid Receptor

Adelaiye-Ogala R, Gryder BE, Nguyen YTM, Alilin AN, Grayson AR, Bajwa W, Jansson KH, Beshiri ML, Agarwal S, Rodriguez-Nieves JA, Capaldo B, Kelly K, VanderWeele DJ
Mol Cancer Ther. Jul;19(7): 1436-1447, 2020. [ Journal Article ]

Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors

Agarwal S, Hynes PG, Tillman HS, Lake R, Abou-Kheir WG, Fang L, Casey OM, Ameri AH, Martin PL, Yin JJ, Iaquinta PJ, Karthaus WR, Clevers HC, Sawyers CL, Kelly K
Cell Rep. Dec 15;13(10): 2147-2158:, [ Journal Article ]