Changqing Xie, M.D., Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10, Room 3B43
- Bethesda, Maryland 20892
- 301-646-8337
- changqing.xie@nih.gov
RESEARCH SUMMARY
I am interested in exploring the potential mechanism of resistance to treatment with immune checkpoint inhibitor in gastrointestinal (GI) malignancy. My focus is to dissect the role of cancer stem cells in cholangiocarcinoma in terms of developing this therapy resistance.
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Changqing Xie, M.D., Ph.D.
Research
My overall goal is to explore the role of cancer stem cells in the development of treatment resistance to immunotherapy in cholangiocarcinoma with the following steps: 1) To investigate the path of cancer stem cells during cholangiocarcinoma; 2) To study the interaction between cancer stem cells and neighboring immune cells during cholangiocarcinoma pathogenesis; and 3) To identify the potential target agents to control cancer stem cells in cholangiocarcinoma.
Publications
Characterization of Immunogenicity of Malignant Cells with Stemness in Intrahepatic Cholangiocarcinoma by Single-Cell RNA Sequencing
Clinical Indicators for Long-Term Survival with Immune Checkpoint Therapy in Advanced Hepatocellular Carcinoma
Immune Checkpoint Inhibitor Associated Hepatotoxicity in Primary Liver Cancer Versus Other Cancers: A Systematic Review and Meta-Analysis
Systemic treatment options for advanced biliary tract carcinoma
Immune Checkpoint Blockade in Combination with Stereotactic Body Radiotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma
Biography
Changqing Xie, M.D., Ph.D.
I received my M.D. and Ph.D from the Xiangya School of Medicine of Central South University. I completed my postdoctoral training in the lab of Dr. Eugene Chen at Morehouse School of Medicine and at the University of Michigan before being promoted as junior faculty at the University of Michigan. Before I started Internal Medicine residency training at East Carolina University, I worked as an Assistant Research Professor at the University of Virginia. I completed Hematology/Oncology training through the NHLBI/NCI Hematology/Oncology Fellowship program with Dr. Tim Greten as my mentor and joined the Thoracic and Gastrointestinal (GI) Malignancies Branch as an Physician-Scientist Early Investigator in 2019.
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