Breadcrumb

C. Norman  Coleman, M.D.

C. Norman Coleman, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Radiation Oncology Branch

RESEARCH SUMMARY

The laboratory research focus is on radiation-induced molecular targets that can be utilized with molecular targeted drug (or immuno-) therapy to enhance the efficacy of radiation therapy. An overarching concept is the exploitation of radiation therapy and the advanced technology now available as 'focused biology' wherein radiation is described by the molecular events produced rather than by just the dose in Gray. We are studying the phenotypic changes after a large single dose as used in hypofractionation and also after multi-fraction radiation at 0.5-2 Gy per fraction to take advantage of the tumor cell adaptation (called MF Adaptive response). Other laboratory interests include studying biomarkers of radiation-related normal tissue injury, nuclear –radiological emergencies supported by NIAID and BARDA.

Areas of Expertise

1) radiation oncology 2) radiation biology 3) molecular targeted therapy 4) radiation stress response for tumor and normal tissue 5) global health 6) health disparities

Publications

Selected Recent Publications

53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy

Eke I, Zong D, Aryankalayil MJ, Sandfort V, Bylicky MA, Rath BH, Graves EE, Nussenzweig A, Coleman CN
Nucleic Acids Res. 48(3): 1314-26, 2020. [ Journal Article ]

Implementation of New Biology-Based Radiation Therapy Technology: When Is It Ready So "Perfect Makes Practice?"

Coleman CN, Ahmed MM
Int J Radiat Oncol Biol Phys. 105(5): 934-37, 2019. [ Journal Article ]

Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L, Coleman CN, Ahmed MM
Cancer Res. 79(17): 4326-30, 2019. [ Journal Article ]

Current and Future Initiatives for Radiation Oncology at the National Cancer Institute in the Era of Precision Medicine

Kunos CA, Coleman CN.
Int J Radiat Oncol Biol Phys. 102(1): 18-25, 2018. [ Journal Article ]

Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials

Coleman CN, Higgins GS, Brown JM, Baumann M, Kirsch DG, Willers H, Prasanna PG, Dewhirst MW, Bernhard EJ, Ahmed MM
Clin Cancer Res. 22(13): 3138-47, 2016.

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Research Biologist
Molykutty J. Aryankalayil, Ph.D.
Postdoctoral Fellow (CRTA)
Michelle Bylicky, Ph.D.
Postbaccalaureate Fellow (CRTA)
Jared May
Postdoctoral Fellow (Visiting)
Sunita Chopra, Ph.D.
Postbaccalaureate Fellow (CRTA)
Shannon Martello
Postbaccalaureate Fellow (CRTA)
Peter Murray