Antoun Toubaji, M.D.

Antoun Toubaji, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology


Dr. Toubaji is a genitourinary (GU) pathologist. He  is interested in studying GU solid tumors, particularly prostate cancer. His research focuses on prostate cancer significant molecular alterations, diagnostic and prognostic biomarkers, and validation of artificial intelligence (AI) and deep learning algorithms for detection and grading of prostate cancer. 

Areas of Expertise

1) prostate cancer, 2) molecular genetics and biomarkers, 3) genitourinary malignancies


Selected Key Publications

Increased gene copy number of ERG on chromosome 21 but not TMPRSS2-ERG fusion predicts outcome in prostatic adenocarcinomas

Toubaji A, Albadine R, Meeker AK, Isaacs WB, Lotan T, Haffner MC, Chaux A, Epstein JI, Han M, Walsh PC, Partin AW, De Marzo AM, Platz EA, Netto GJ.
Mod Pathol. 24(11): 1511-20, 2011. [ Journal Article ]

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

Haffner MC, Aryee MJ, Toubaji A, Esopi DM, Albadine R, Gurel B, Isaacs WB, Bova GS, Liu W, Xu J, Meeker AK, Netto G, De Marzo AM, Nelson WG, Yegnasubramanian S.
Nat Genet. 42(8): 668-75, 2010. [ Journal Article ]

Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry

Chen YB, Brannon AR, Toubaji A, Dudas ME, Won HH, Al-Ahmadie HA, Fine SW, Gopalan A, Frizzell N, Voss MH, Russo P, Berger MF, Tickoo SK, Reuter VE.
Am J Surg Pathol. 38(5): 627-37, 2014. [ Journal Article ]

Immunohistochemical expression of minichromosome maintenance complex protein 2 predicts biochemical recurrence in prostate cancer: a tissue microarray and digital imaging analysis-based study of 428 cases

Toubaji A, Sutcliffe S, Chaux A, Lecksell K, Hicks J, De Marzo AM, Platz EA, Netto GJ.
Hum Pathol. 43(11): 1852-65, 2012. [ Journal Article ]

Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer

Wu RC, Young IC, Chen YF, Chuang ST, Toubaji A, Wu MY.
Nat Commun. 10(1): 4332, 2019. [ Journal Article ]