Breadcrumb

Alan O. Perantoni, Ph.D.

Alan O. Perantoni, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Perantoni devoted his efforts to identifying (1) the ligands responsible for renal progenitor/stem cell survival and differentiation, (2) the molecular targets of those ligands, (3) the mechanisms responsible for the dysregulation of normal signaling in Wilms tumor, and (4) the targets of dysregulation in those tumors.

Areas of Expertise

1) kidney and reproductive tract development 2) renal progenitor signaling 3) STAT transcription factors in development and cancer 4) FGF and WNT signaling in kidney 5) Wilms tumor

Publications

Selected Key Publications

Preferential Propagation of Competent SIX2+ Nephronic Progenitors by LIF/ROCKi Treatment of the Metanephric Mesenchyme

Tanigawa S, Sharma N, Hall MD, Nishinakamura R, Perantoni AO.
Stem Cell Reports. Sep 8;5(3): 435-47, 2015. [ Journal Article ]

Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension

Yun K, Ajima R, Sharma N, Costantini F, Mackem S, Lewandoski M, Yamaguchi TP, Perantoni AO.
Hum Mol Genet. Dec 20;23(25): 6807-14, 2014. [ Journal Article ]

Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation

Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ.
Nat. Cell Biol. 15: 1035-44, 2013. [ Journal Article ]

FGF8 is essential for formation of the ductal system in the male reproductive tract

Kitagaki J, Ueda Y, Chi X, Sharma N, Elder CM, Truffer E, Costantini F, Lewandoski M, Perantoni AO.
Development. 138: 5369-78, 2011. [ Journal Article ]

Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism

Tanigawa S, Wang H, Yang Y, Sharma N, Tarasova N, Ajima R, Yamaguchi TP, Rodriguez LG, Perantoni AO.
Dev Biol. 352: 58-69, 2011. [ Journal Article ]