TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone

TGFβ signaling in the germinal center

Albright et al. describe the previously unknown function of TGFβ in promoting the transition of GCB cells from LZ to DZ. The cover shows staining for phosphorylated Smad2 (red) in a Peyer’s patch from a wild-type mouse.

Lab/Branch/Program: 
Lymphoid Malignancies Branch
Citation: 
TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone. 
Albright AR, Kabat J, Li M, Raso F, Reboldi A and Muppidi JR. J Exp Med. 216(11):2531-2545, 2019. 
Published Date: 
November, 2019