Joshua A. Welsh, Ph.D.

Joshua A. Welsh, Ph.D.
Postdoctoral Fellow (CRTA)

In my current position  I am helping to develop a scalable clinical pipeline that will enable the use of extracellular vesicles (EVs) as clinical biomarkers. This research includes exploring novel ways to label, detect, and purify EVs, and utilises a variety of techniques such as high-sensitivity nanoparticle sorting, single-fluorophore detection flow cytometry, multiplex analysis, sequencing, proteomics, and multi-dimensional analysis techniques.

Areas of Expertise
1) high-sensitivity flow cytometry 2) flow cytometer standardisation 3) multidimensional data analysis 4) translational medicine

Contact Info

Joshua A. Welsh, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 41, Room D702B
Bethesda, 20892
Ph: 240-760-6673
joshua.welsh@nih.gov

In my current position I am helping to develop a scalable clinical pipeline that will enable the use of extracellular vesicles (EVs) as clinical biomarkers. This research includes exploring novel ways to label, detect, and purify EVs, and utilises a variety of techniques such as high-sensitivity nanoparticle sorting, single-fluorophore detection flow cytometry, multiplex analysis, sequencing, proteomics, and multi-dimensional analysis techniques.

Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Clinical Research, Immunology

Selected Recent Publications

  1. Welsh JA, Kepley J, Rosner A, Horak P, Berzofsky JA and Jones JC.
    Sensors. 18(8): E2461, 2018. [ Journal Article ]
  2. Wiklander OPB, Bostancioglu RB, Welsh JA, Zickler AM, Murke F, Corso G, Felldin U, Hagey DW, Evertsson B, Liang X-M, Gustafsson MO, Mohammad DK, Wiek C, Hanenberg H, Bremer M, Gupta D, Björnstedt M, Giebel B, Nordin JZ, Jones JC, EL Andaloussi S and Görgens A.
    Frontiers in Immunology. 9: Article 1326, 2018. [ Journal Article ]
  3. Welsh JA, Scorletti E, Clough GF, Englyst NA and Byrne CD.
    Journal of Leukocyte Biology. 104(3): 631-639, 2018. [ Journal Article ]
  4. Welsh JA, Holloway JA, Wilkinson JS and Englyst NA.
    Frontiers in Cell and Developmental Biology. 5: Article 78, 2017. [ Journal Article ]

I obtained my Ph.D. from the University of Southampton, where I researched the development of high-sensitivity flow cytometers with industry. Along with equipment development I created novel particle scattering models to allow standardization of small particle detection using flow cytometry. I would go on to apply these techniques to a number of translational studies including: acute ischemic stroke, cardiac bypass surgery, nonalcoholic fatty liver disease and allergy development.

Awards:

  • Federal Technology Transfer Award, NIH, 2018
  • Summer Research Mentor Award, NIH, 2018
  • 2nd Prize for Best Oral Presentations, UKEV Forum, 2017
  • Student Travel Award, International Society for Advancement of Cytometry, 2016
  • International Conference Attendance Fund, University of Southampton, 2016
  • Researcher Links/Newton Award, British Council, 2016
  • Student Travel Award, International Society for Advancement of Cytometry, 2015
  • International Conference Attendance Fund, University of Southampton, 2015
  • Researcher Links Award, British Council, 2015
  • Young Extraordinary Brits Award: Innovation, Jack Wills, 2014
  • Best Overall 3rd Year Experimental Project, University of Leicester, 2013
  • Awarded 1st Year University Scholarship, University of Leicester, 2010
  1. Joshua Welsh Website - Up to date versions of my software. 
  2. ISAC-ISEV-ISTH FCM Working Group