A novel imaging approach for prostate cancer is tested in new clinical trial

Prostate cancer imaging

Using a cutting edge approach to treat prostate tumors that have returned after a radiation treatment, physicians believe they can target tumors with pinpoint accuracy using high quality prostate MRI and an investigational imaging technique to guide focal, ablative radiation treatment, while sparing surrounding organs from possible injury. The image shows the dose plan in color wash treating the tumor but not the entire prostate (shown in blue) while sparing the bladder (yellow) and rectum (brown).
Photo credit: Deborah Citrin, M.D.

Generally, prostate cancer patients who have failed standard radiation therapy have the options of surgery, radioactive seed implantation or cryoablation. These treatments are invasive and can have serious side effects. Deborah Citrin, M.D., of the Radiation Oncology Branch is leading a study of stereotactic body radiation therapy (SBRT) to treat prostate cancer that has recurred locally after standard radiation therapy. With SBRT, specially designed imaging techniques identify prostate cancer and pinpoint the tumor’s exact location. This enables  physicians to deliver a high dose of radiation directly to the tumor within the prostate gland. Thus, SBRT can deliver escalating doses of potent radiation in a shorter course of treatment than standard radiation therapy. According to Dr. Citrin, “The use of a novel imaging study to minimize the exposure to uninvolved tissue may enhance our ability to cure these recurrent tumors and reduce side effects for our patients - an important goal for those suffering from recurrent prostate cancer.” SBRT has shown promising results in previous studies. The goal of this study is to define the best dose of SBRT for patients whose prostate cancer has recurred after standard radiotherapy.

For more information on this trial, please visit: https://ccr.cancer.gov/radiation-oncology-branch/deborah-e-citrin

The Center for Cancer Research is NCI’s internal cancer center, a publicly funded organization working to improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.  Highly trained physician-scientists develop and carry out clinical trials to create the medicines of tomorrow by treating patients at the world’s largest dedicated research hospital on the campus of the National Institutes of Health in Bethesda, Maryland. Search all CCR clinical trials, and subscribe to have the latest CCR clinical trials sent to your inbox.

Summary Posted: 11/2017