Laboratory of Genitourinary Cancer Pathogenesis

Chief
Kathleen Kelly, Ph.D.

LGCP Branch PhotoThe Laboratory of Genitourinary Cancer Pathogenesis (LGCP) focuses on genitourinary (GU) cancers, especially prostate cancer, with the goal of understanding fundamental processes of cancer pathogenesis and translating this knowledge into clinical applications. We work within the Urologic Oncology Collaborative Group, which brings together integrated basic and translational research, surgical oncology, and medical oncology for the purpose of improving the detection, diagnosis, and treatment of patients with GU cancers. Specifically, LGCP includes mechanism-oriented research programs to investigate 1) the action of common prostate cancer genomic mutations, 2) microenvironmental influences on tumor progression and metastasis development, 3) castration resistance and prostate cancer stem cells, and 4) the regulation of responses to cell death pathways.

Position Keywords Contact Name Contact E-mail Number of Positions
Postgraduate Fellow - prostate cancer, computer science

prostate cancer, computer science, multi-omics data

 Adam Sowalsky adam.sowalsky@nih.gov 1
Postdoctoral Fellow - prostate cancer, computational biology

prostate cancer, computational biology, multi-omics data

 Adam Sowalsky adam.sowalsky@nih.gov 1
Postbac Fellow - prostate cancer, multi-omics data

prostate cancer, computer science, multi-omics data

 Adam Sowalsky adam.sowalsky@nih.gov 1

LGCP Microscopy Core

The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) Microscopy Core provides training, guidance, and state-of-the-art service to LCGP scientists as well as other NCI-CCR researchers who require in vivo imaging or confocal microscopy techniques as part of their research efforts.

The LGCP Microscopy Core currently houses:

Carl Zeiss LSM 780 laser scanning confocal microscope  

1) A Carl Zeiss LSM 780 laser scanning confocal microscope equipped with two PMTs and one 32 channel GaAsP spectral detector.

Carl Zeiss AxioObserver.Z1 epifluorescent microscope

2) Two Zeiss AxioObserver.Z1 epifluorescent scopes equipped with a digital camera and Zen software.

Carl Zeiss AxioScan.Z1 slide scanner

3) A Zeiss AxioScan.Z1 slide scanner capable of imaging fluorescent or brightfield slides

Olympus VivaView fluorescence incubator microscope

4) An Olympus VivaView fluorescence incubator microscope for long-term live cell imaging

Please visit the LGCP Microscopy Core website for more information about our instrumentation, policies, software, techniques, publications, and how to access services. Image acquisition and analysis is provided free of charge.

Scientists who are fully trained in confocal microscopy work independently while inexperienced users are encouraged to arrange for training or to establish a collaboration with Ross Lake.

The LGCP Seminar Series runs throughout the year.  Seminars are Wednesday afternoons from 3-4 pm Building 37.  Please note the Room Locations

  • 2nd Floor : Room 2041/2107
  • 4th Floor : Room 4041/4107
  • 6th Floor : Room 6041/6107

Upcoming Seminars

Wednesday January 8th 2020 : David Takeda : Location : 6th Floor

Wednesday January 22nd 2020 : Berkley Gryder : Location : 6th Floor

Wednesday February 5th : Ilya Senatorov : 4th Floor

Wednesday February 19th : Brian Capaldo : Location : 4th Floor

Wednesday March 18th : TBD : Location : 2nd Floor

Wednesday March 18th : Remi Adelaiye-Ogala : Location : 6th Floor

Wednesday May 13th : Sonam Raj : Location : 6th Floor

Wednesday June 10th : Scott Wilkinson : Location : 4th Floor

Wednesday July 15th : Nichelle Whitlock : Location : 6th Floor

Wednesday August 12th : Supreet Agarwal : Location : 4th Floor

Wednesday September 16th : Mike Beshiri : Location : 2nd Floor

Wednesday October 14th : Maggie White : Location : 4th Floor

About

LGCP Branch PhotoThe Laboratory of Genitourinary Cancer Pathogenesis (LGCP) focuses on genitourinary (GU) cancers, especially prostate cancer, with the goal of understanding fundamental processes of cancer pathogenesis and translating this knowledge into clinical applications. We work within the Urologic Oncology Collaborative Group, which brings together integrated basic and translational research, surgical oncology, and medical oncology for the purpose of improving the detection, diagnosis, and treatment of patients with GU cancers. Specifically, LGCP includes mechanism-oriented research programs to investigate 1) the action of common prostate cancer genomic mutations, 2) microenvironmental influences on tumor progression and metastasis development, 3) castration resistance and prostate cancer stem cells, and 4) the regulation of responses to cell death pathways.

PI & Key Staff

Positions

Position Keywords Contact Name Contact E-mail Number of Positions
Postgraduate Fellow - prostate cancer, computer science

prostate cancer, computer science, multi-omics data

 Adam Sowalsky adam.sowalsky@nih.gov 1
Postdoctoral Fellow - prostate cancer, computational biology

prostate cancer, computational biology, multi-omics data

 Adam Sowalsky adam.sowalsky@nih.gov 1
Postbac Fellow - prostate cancer, multi-omics data

prostate cancer, computer science, multi-omics data

 Adam Sowalsky adam.sowalsky@nih.gov 1

Cores

LGCP Microscopy Core

The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) Microscopy Core provides training, guidance, and state-of-the-art service to LCGP scientists as well as other NCI-CCR researchers who require in vivo imaging or confocal microscopy techniques as part of their research efforts.

The LGCP Microscopy Core currently houses:

Carl Zeiss LSM 780 laser scanning confocal microscope  

1) A Carl Zeiss LSM 780 laser scanning confocal microscope equipped with two PMTs and one 32 channel GaAsP spectral detector.

Carl Zeiss AxioObserver.Z1 epifluorescent microscope

2) Two Zeiss AxioObserver.Z1 epifluorescent scopes equipped with a digital camera and Zen software.

Carl Zeiss AxioScan.Z1 slide scanner

3) A Zeiss AxioScan.Z1 slide scanner capable of imaging fluorescent or brightfield slides

Olympus VivaView fluorescence incubator microscope

4) An Olympus VivaView fluorescence incubator microscope for long-term live cell imaging

Please visit the LGCP Microscopy Core website for more information about our instrumentation, policies, software, techniques, publications, and how to access services. Image acquisition and analysis is provided free of charge.

Scientists who are fully trained in confocal microscopy work independently while inexperienced users are encouraged to arrange for training or to establish a collaboration with Ross Lake.

Contact Info

Laboratory of Genitourinary Cancer Pathogenesis
Center for Cancer Research
National Cancer Institute
Building 37, Room 1068
Bethesda, MD 20892-4263
Ph: 240-760-6827
Administrative Assistant (Contr.)
Deanna Spear Garner
240.760.7933
Technical Lab Manager
Lei Fang, Ph.D.
240.760.6821