Laboratory of Genitourinary Cancer Pathogenesis
The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) focuses on genitourinary (GU) cancers, especially prostate cancer, with the goal of understanding fundamental processes of cancer pathogenesis and translating this knowledge into clinical applications. We work within the Urologic Oncology Collaborative Group, which brings together integrated basic and translational research, surgical oncology, and medical oncology for the purpose of improving the detection, diagnosis, and treatment of patients with GU cancers. Specifically, LGCP includes mechanism-oriented research programs to investigate 1) the action of common prostate cancer genomic mutations, 2) microenvironmental influences on tumor progression and metastasis development, 3) castration resistance and prostate cancer stem cells, and 4) the regulation of responses to cell death pathways.
LGCP Microscopy Core
The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) Microscopy Core provides training, guidance, and state-of-the-art service to LCGP scientists as well as other NCI-CCR researchers who require in vivo imaging or confocal microscopy techniques as part of their research efforts.
The current equipment in the Core includes:
- Carl Zeiss LSM 780 laser scanning confocal microscope equipped with two PMTs and one 32 channel GaAsP spectral detector.
- Carl Zeiss AxioObserver.Z1 epifluorescent microscope equipped with a Hamamatsu ORCA-Flash 4.0 camera and Zen software.
- Two Carl Zeiss AxioScan.Z1 slide scanners capable of imaging fluorescent and brightfield slides
- Nikon Eclipse Ti2 fluorescence microscope (optimized for smRNAFISH imaging) equipped with a Photometrics Prime BSI sCMOS camera and Elements software.
Please visit the LGCP Microscopy Core website for more information about our instrumentation, policies, software, techniques, publications, and how to access services.
The Laboratory of Genitourinary Cancer Pathogenesis Seminar Series
The LGCP Seminar Series runs throughout the year. Seminars are Wednesday afternoons from 3-4 pm in Building 37, Room 4041/4107.
Visit our archives to learn more about past seminars.
Upcoming Seminars: 2022
Center for Cancer Research National Cancer Institute
- Building 37, Room 1068
- Bethesda, MD 20892-4263