Staff Scientist - Tumor Immunology, Organoids

Date Posted
Position is with
Name of Hiring Official/Investigator

Job Description

A Staff Scientist position is available for individuals interested in the Muthuswamy laboratory at the Laboratory of Cancer Biology and Genetics (LCBG), National Cancer Institute, NIH, Bethesda, MD. The Staff Scientist will be engaged in a research program aimed at generating patient-tumor-derived organoids and using them to discover and characterize tumor-targeting T-cell receptors and understand immune evasion mechanisms in cancer employing an organoid-T-cell coculture platform (PMID:34789550; 35446942). The position will employ high-resolution imaging, in vivo approaches, and cell molecular techniques.

The candidate should have a strong passion for translational or basic cancer research with a willingness to work as part of a team. The candidate will be given significant academic freedom to pursue their ideas in the context of tumor immunology within the framework of the laboratory's research interests and the opportunity to mentor post-bacs and graduate students. The candidate should have excellent communication skills and will be responsible for writing and editing manuscripts and reviewing articles related to the laboratory’s research efforts.

The Staff Scientist will partake in weekly lab meetings and bi-weekly one-on-one meetings. The candidate will have the opportunity to present their research at department research seminars, NCI-wide seminars, and national and international conferences. In addition, the staff scientists will receive mentoring from the PI for their career development and have access to multiple training opportunities at NCI and LCBG, outlined in the Trainee Commitment section of the LCBG website.

Interested candidates, send CV, a one-page summary of your past research efforts, and names of three references to

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Government Position (Salary commensurate with experience)
Work Schedule
Full-time (In-Person)
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

Ph.D. or equivalent in immunology or related discipline with a proven track record of working with T-cells with multiple publications as the lead author. The candidate should have an in-depth understanding of T-cell biology and a broader knowledge of immunology. An in-depth knowledge of cancer biology would be preferred. In addition, the candidate should have substantial training in cell or molecular techniques and the ability to use in vivo and high-resolution imaging approaches. 

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
  • CV/Resume
  • 3 References
  • Summary of Research Experience
Contact Information
Contact Name
Senthil Muthuswamy
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.