Staff Scientist - Genetics, yeast

Date Posted
Position is with
Name of Hiring Official/Investigator

Job Description

The Yeast Genome Stability Section is focused on defining molecular mechanisms that regulate faithful chromosome segregation in budding yeast and human cells. We are specifically focused on defining mechanisms that restrict the localization of centromeric histone H3 variant CENP-A/Cse4 to centromeric DNA to prevent chromosomal instability (CIN), an important hallmark of cancers. Mislocalization of overexpressed CENP-A/Cse4, which is observed in many cancers, has been shown to contribute to aneuploidy in yeast and human cells. Our laboratory has defined a key role for posttranslational modifications (PTMs) of CENP-A/Cse4 such as sumoylation and ubiquitination in preventing its mislocalization to non-centromeric regions. The research laboratory is investigating the molecular basis and biological consequences of CENP-A/Cse4 mislocalization. Our studies are aimed at the Identification and characterization of pathways that prevent and promote the mislocalization of CENP-A/Cse4 and mechanisms that regulate eviction of mislocalized CENP-A/Cse4.

The candidate will work collaboratively with other members of the laboratory, Genetics Branch members and extramural investigators. These studies provide an excellent opportunity to integrate basic science with translational outcomes. The successful applicant will provide demonstrable leadership and mentoring in the planning, execution, interpretation and communication of research projects with publications in the Yeast Genome Stability Section. The selected candidate will also work closely with the section head to identify future research opportunities and develop a strategic plan to achieve these goals.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Government Position (Salary commensurate with experience)
Work Schedule
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

The Yeast Genome Stability Section is looking for a talented, enthusiastic, and highly motivated yeast geneticist with a strong background in molecular biology and biochemistry. Extensive experience with the yeast model system is essential for this position. Interested candidates must have a Ph.D. or equivalent doctoral degree and postdoctoral training in molecular biology, cell biology, biochemistry, genetics or a related discipline. Candidates also should have a strong record of peer-reviewed publications that provides evidence of their collaborative abilities and expertise as well as experience in preparing written scientific reports and oral presentations.

Preferred Skills

Experience with biochemical approaches for post-translational modifications and genome wide analysis is preferred.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
  • CV/Resume
  • Statement of Research Goals
  • 3 References
  • Cover Letter
  • Summary of Research Experience
  • Diversity Statement
Contact Information
Contact Name
Munira A Basrai
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.