We are looking for an enthusiastic and motivated synthetic organic chemist or medicinal chemist to join our research team. The fellow will join an interdisciplinary team developing HIV-1 integrase strand transferinhibitors (INSTIs) intended to retain antiviral efficacy against resistant mutant forms of integrase. The position is primarily synthetic organic in nature with a focus on designing and synthesizing heterocyclicmolecules. The fellow will combine insights derived from antiviral assays together with structures of synthetic inhibitors bound to integrase to guide the ongoing design of next-generation analogs.
Relevant publications include: ACS. Chem. Biol. 2016, 11, 1074; J. Med. Chem. 2017 60, 7315; Science 2020, 367, 810.
Qualifications and Job Details
Required and Preferred Skills
Doctoral degree in synthetic or medicinal chemistry with competence in planning and executing multi-step synthesis of complex organic molecules and associated spectral analysis of intermediates and products
Experience synthesizing chiral heterocyclic compounds
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
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