Postdoctoral Fellow - Synthetic organic chemistry, multi-step synthesis

Date Posted
Position is with
Name of Hiring Official/Investigator

Job Description

We are looking for an enthusiastic and motivated synthetic organic chemist or medicinal chemist to join our research team. The fellow will join an interdisciplinary team developing HIV-1 integrase strand transferinhibitors (INSTIs) intended to retain antiviral efficacy against resistant mutant forms of integrase. The position is primarily synthetic organic in nature with a focus on designing and synthesizing heterocyclicmolecules. The fellow will combine insights derived from antiviral assays together with structures of synthetic inhibitors bound to integrase to guide the ongoing design of next-generation analogs. 

Relevant publications include: ACS. Chem. Biol. 2016, 11, 1074; J. Med. Chem. 2017 60, 7315; Science 2020, 367, 810.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Training Position (Starting stipend: $65,100, bonuses may apply)
Work Schedule
Full-time (In-Person)
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

Doctoral degree in synthetic or medicinal chemistry with competence in planning and executing multi-step synthesis of complex organic molecules and associated spectral analysis of intermediates and products

Preferred Skills

Experience synthesizing chiral heterocyclic compounds

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply
  • CV/Resume
  • Statement of Research Goals
  • Cover Letter
  • Summary of Research Experience
Contact Information
Contact Name
Terrence R. Burke, Jr.
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.