Fully funded postdoctoral and research fellow positions for experimental and computational biologists are available in Dr. Michael Aregger’s Functional Genomics Section within the Molecular Targets Program at the CCR, NCI, NIH. Our group’s research focuses on how cancer cells rewire gene expression and metabolism to adapt to changing environmental conditions. We apply CRISPR-based genome engineering tools and functional genomics approaches to reveal genetic interactions and cancer dependencies, and to identify regulators of metabolic plasticity in cancer cells. Our lab focuses on developing innovative genetic screening approaches and we have access to state-of-the art facilities including next-generation sequencing, single-cell analysis platforms, mass spectrometry, flow cytometry, natural products and synthetic compound libraries, and animal facilities.
Several projects are currently available including: 1) applying high-throughput strategies to identify context-dependent fitness genes across changing environmental conditions; 2) mapping genetic interactions between metabolic genes; 3) identification of synergistic targets with metabolic inhibitors.
Recent related publications:
1. Application of CHyMErA Cas9-Cas12a combinatorial genome-editing platform for genetic interaction mapping and gene fragment deletion screening Nature Protocols, 2021.
2. Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform Nature Biotechnology, 2020.
3. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism Nature Metabolism, 2020.
Qualifications and Job Details
Required and Preferred Skills
Applicants must have a Ph.D. or M.D./Ph.D degree and expertise in molecular biology, genetics, biochemistry, cell biology, mammalian cell culture or bioinformatics. Motivated candidates who are interested in innovative research using cutting-edge technologies are encouraged to apply.
Applicants with research experience in functional genomics, CRISPR technology, molecular biology, single-cell analytics and bioinformatics are especially encouraged to apply.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.
Applicants should send a brief cover letter, CV including bibliography, and contact information of three references to Michael Aregger: email@example.com